Five-year survival with combined nivolumab and ipilimumab in advanced melanoma: New England Journal of Medicine
James Larkin,Vanna Chiarion-Sileni,Rene Gonzalez,Jean-Jacques Grob,Piotr Rutkowski,Christopher D. Lao,Charles Lance Cowey,Dirk Schadendorf,John Wagstaff,R. Dummer,Pier Francesco Ferrucci,Michael Smylie,David W. Hogg,A. Hill,Ivan Marquez-Rodas,John B A G Haanen,Massimo Guidoboni,Michele Maio,Patrick Schöffski,M.S. Carlino,C. Lebbé,Grant A. McArthur,Paolo A. Ascierto,G.A. Daniels,Georgina V. Long,Lars Bastholt,Jasmine I. Rizzo,A. Balogh,Andriy Moshyk,F.S. Hodi,Jedd D. Wolchok +30 more
TLDR
Among patients with advanced melanoma, sustained long-term overall survival at 5 years was observed in a greater percentage of patients who received nivolumab plus ipilimumab or nivoliumab alone than in those who received ipil optimumab alone, with no apparent loss of quality of life in the patients whoreceived regimens containing nivolinumab.Abstract:
BACKGROUND\nNivolumab plus ipilimumab or nivolumab alone resulted in longer progression-free and overall survival than ipilimumab alone in a trial involving patients with advanced melanoma. We now report 5-year outcomes in the trial.\n\n\nMETHODS\nWe randomly assigned patients with previously untreated advanced melanoma to receive one of the following regimens: nivolumab (at a dose of 1 mg per kilogram of body weight) plus ipilimumab (3 mg per kilogram) every 3 weeks for four doses, followed by nivolumab (3 mg per kilogram every 2 weeks); nivolumab (3 mg per kilogram every 2 weeks) plus ipilimumab-matched placebo; or ipilimumab (3 mg per kilogram every 3 weeks for four doses) plus nivolumab-matched placebo. The two primary end points were progression-free survival and overall survival in the nivolumab-plus-ipilimumab group and in the nivolumab group, as compared with the ipilimumab group.\n\n\nRESULTS\nAt a minimum follow-up of 60 months, the median overall survival was more than 60.0 months (median not reached) in the nivolumab-plus-ipilimumab group and 36.9 months in the nivolumab group, as compared with 19.9 months in the ipilimumab group (hazard ratio for death with nivolumab plus ipilimumab vs. ipilimumab, 0.52; hazard ratio for death with nivolumab vs. ipilimumab, 0.63). Overall survival at 5 years was 52% in the nivolumab-plus-ipilimumab group and 44% in the nivolumab group, as compared with 26% in the ipilimumab group. No sustained deterioration of health-related quality of life was observed during or after treatment with nivolumab plus ipilimumab or with nivolumab alone. No new late toxic effects were noted.\n\n\nCONCLUSIONS\nAmong patients with advanced melanoma, sustained long-term overall survival at 5 years was observed in a greater percentage of patients who received nivolumab plus ipilimumab or nivolumab alone than in those who received ipilimumab alone, with no apparent loss of quality of life in the patients who received regimens containing nivolumab. (Funded by Bristol-Myers Squibb and others; CheckMate 067 ClinicalTrials.gov number, NCT01844505.).read more
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Journal ArticleDOI
Nivolumab plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer.
Matthew D. Hellmann,Luis Paz-Ares,Reyes Bernabe Caro,B. Zurawski,Sang-We Kim,Enric Carcereny Costa,Keunchil Park,A. Alexandru,L. Lupinacci,Emmanuel de la Mora Jimenez,Hiroshi Sakai,Istvan Albert,Alain Vergnenegre,Solange Peters,Konstantinos N. Syrigos,Fabrice Barlesi,Martin Reck,Hossein Borghaei,Julie R. Brahmer,Kenneth J. O'Byrne,William J. Geese,Prabhu Bhagavatheeswaran,Sridhar K. Rabindran,Ravi S. Kasinathan,F. E. Nathan,Suresh S. Ramalingam +25 more
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First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non-small-cell lung cancer (CheckMate 9LA): an international, randomised, open-label, phase 3 trial
Luis Paz-Ares,Tudor-Eliade Ciuleanu,Manuel Cobo,Michael Schenker,B. Zurawski,Juliana Janoski de Menezes,Eduardo Richardet,Jaafar Bennouna,Enriqueta Felip,O. Juan-Vidal,A. Alexandru,Hiroshi Sakai,Alejo Lingua,Pamela Salman,Pierre-Jean Souquet,Pedro Rafael Martins De Marchi,C. Martin,Maurice Pérol,Arnaud Scherpereel,Shun Lu,Thomas John,David P. Carbone,S. Meadows-Shropshire,Shruti Agrawal,Abderrahim Oukessou,J. Yan,Martin Reck +26 more
TL;DR: In this article, the authors investigated whether the addition of a limited course (two cycles) of chemotherapy to this combination would further enhance the clinical benefit of first-line nivolumab plus ipilimumab for advanced non-small-cell lung cancer (NSCLC).
Journal ArticleDOI
First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial.
Paul Baas,Arnaud Scherpereel,Anna K. Nowak,Nobukazu Fujimoto,Solange Peters,Anne S. Tsao,Aaron S. Mansfield,Sanjay Popat,Thierry Jahan,Scott J. Antonia,Youssef Oulkhouir,Yolanda Bautista,Robin Cornelissen,Laurent Greillier,Francesco Grossi,Dariusz M. Kowalski,Jerónimo Rodríguez-Cid,Praveen Aanur,Abderrahim Oukessou,Christine Baudelet,Gérard Zalcman +20 more
TL;DR: The CheckMate 743 trial as mentioned in this paper showed that nivolumab plus ipilimumab significantly improved overall survival compared to standard-of-care chemotherapy for non-small-cell lung cancer.
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Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma
TL;DR: In this paper , the authors evaluated relatlimab and nivolumab as a fixed-dose combination for patients with previously untreated metastatic or unresectable melanoma.
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