Journal ArticleDOI
Food-drug interaction between ferulic acid and nateglinide involving the fluorescein/H+ cotransport system.
Shirou Itagaki,Yoko Kobayashi,Yukio Otsuka,Sayaka Kubo,Masaki Kobayashi,Takeshi Hirano,Ken Iseki +6 more
TLDR
It is reported here for the first time that ferulic acid, which is widely used as a functional food, affects the transport of clinical agents and should be aware of the potential of food-drug interactions and to act in order to prevent undesirable and harmful clinical consequences.Abstract:
In clinical, patients usually take many kinds of drugs at the same time. Thus, drug-drug interactions involving transporters can often directly affect the therapeutic safety and efficacy of many drugs. However, there have been few studies on food-drug interactions involving transporters. Dietary polyphenols have been widely assumed to be beneficial to human health. Polyphenols are commercially prepared and used as functional foods. We report here for the first time that ferulic acid, which is widely used as a functional food, affects the transport of clinical agents. It is important to be aware of the potential of food-drug interactions and to act in order to prevent undesirable and harmful clinical consequences.read more
Citations
More filters
Journal ArticleDOI
In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid
Yuki Sato,Shirou Itagaki,Toshimitsu Kurokawa,Jiro Ogura,Masaki Kobayashi,Takeshi Hirano,Mitsuru Sugawara,Ken Iseki +7 more
TL;DR: It is found that both chlorogenic acid and caffeic acid had effects on intestinal ischemia-reperfusion injury, and it is possible that caffeic Acid plays a major role in the protective effect of chlorogenic Acid against ischemIA-rePerfusion Injury.
Journal ArticleDOI
Bioavailability of bioactive food compounds: a challenging journey to bioefficacy
Maarit Rein,Mathieu Renouf,Cristina Cruz-Hernandez,Lucas Actis-Goretta,Sagar K. Thakkar,Marcia da Silva Pinto +5 more
TL;DR: This review focuses on some of the major factors affecting the bioavailability of the aforementioned bioactive food compounds.
Journal ArticleDOI
Chemistry, natural sources, dietary intake and pharmacokinetic properties of ferulic acid: A review
TL;DR: The absorption and metabolism of FA seem to be dose dependent at least in experimental settings, and further pharmacokinetic and pharmacodynamic studies are required to characterize the impact of FA on human health.
Journal ArticleDOI
Biosynthesis, natural sources, dietary intake, pharmacokinetic properties, and biological activities of hydroxycinnamic acids
Hesham R. El-Seedi,Hesham R. El-Seedi,Asmaa M. A. El-Said,Shaden A. M. Khalifa,Ulf Göransson,Lars Bohlin,Anna-Karin Borg-Karlson,Robert Verpoorte +7 more
TL;DR: The chemistry, biosynthesis, natural sources, dietary intake, and pharmacokinetic properties of hydroxycinnamic acids are discussed.
Journal ArticleDOI
In vitro and in vivo antioxidant properties of ferulic acid: a comparative study with other natural oxidation inhibitors.
Shirou Itagaki,Toshimitsu Kurokawa,Chie Nakata,Yoshitaka Saito,Setsu Oikawa,Masaki Kobayashi,Takeshi Hirano,Ken Iseki +7 more
TL;DR: In vitro and in vivo experiments on antioxidant activities of ferulic acid focused on superoxide anion scavenging activity, xanthine oxidase inhibition activity, and chain- Breaking activity found that chain-breaking activity may play a contributory role in the protective effect offerulic acid on oxidative injury in humans and in in vivo studies.
References
More filters
Journal ArticleDOI
Dietary Intake and Bioavailability of Polyphenols
TL;DR: Both chemical and biochemical factors that affect the absorption and metabolism of polyphenols are reviewed, with particular emphasis on flavonoid glycosides.
Journal ArticleDOI
Vegetables, Fruit, and Cancer Prevention: A Review
TL;DR: The evidence for a protective effect of greater vegetable and fruit consumption is consistent for cancers of the stomach, esophagus, lung, oral cavity and pharynx, endometrium, pancreas, and colon, and the types of vegetables or fruit that most often appear to be protective against cancer are raw vegetables.
Journal ArticleDOI
Antioxidants in human health and disease
TL;DR: Experimental approaches to the optimization of antioxidant nutrient intake are proposed, and interest is also growing in the role of plant phenolics, especially flavonoids.
Journal ArticleDOI
Phyto-oestrogens and Western Diseases
Herman Adlercreutz,Witold Mazur +1 more
TL;DR: Evidence is provided suggesting that both lignans and isoflavonoids may prevent the development of cancer as well as atherosclerosis, and no definite recommendations can be made as to the dietary amounts needed for prevention of disease.
Journal ArticleDOI
Does diet or alcohol explain the French paradox
Michael H. Criqui,B.L Ringel +1 more
TL;DR: It is concluded that ethanol, particularly wine ethanol, is inversely related to CHD but not to longevity in populations, and the use of alcohol for cardioprotective purposes should not be encouraged as a public health measure.