Open AccessJournal Article
Frequency of acute hepatitis C after needle stick injury and its treatment outcome.
Bader Faiyaz Zuberi,Faisal Faiyaz Zuberi,Syed Raizul Hasan,Raj Kumar,Sajjad Ali Memon,Salahuddin Afsar +5 more
TLDR
Acute HCV is an uncommon disease to diagnose; it has favorable response to therapy if initiated early after a strict surveillance of patients for 8-16 weeks.Abstract:Â
Objective: To determine the frequency of acute HCV infection after needle stick injury and its treatment outcome. Methodology: Patients with HCV positive needle stick injury and reporting within 72 hours of incident were selected. Co-infections with HBV, HDV, HIV, hematological disorders and depression were excluded. Anti-HCV was done at presentation and those testing positive were excluded. HCV RNA was done after two weeks or anti-HCV after six weeks of incident. Those testing positive were kept under observation for 16 weeks for spontaneous resolution. After this period HCV RNA and Genotype were done and therapy with Peg-interferon was started. Rapid, early and sustained virological responses were checked. Results: Two hundred eight patients with HCV positive needle stick injury were selected, 10 (4.8%) developed acute HCV infection out of them one (10%) had spontaneous recovery during the observation period of 16 weeks. seven (77.8%) achieved rapid virological response and eight (88.9%) achieved sustained virological response. Conclusions: Acute HCV is an uncommon disease to diagnose; it has favorable response to therapy if initiated early after a strict surveillance of patients for 8-16 weeks.read more
Citations
More filters
Journal ArticleDOI
The epidemiology of hepatitis C virus in Pakistan: systematic review and meta-analyses
TL;DR: To characterize hepatitis C virus (HCV) epidemiology in Pakistan and estimate the pooled mean HCV antibody prevalence in different risk populations, all available records of HCV incidence and/or prevalence from 1989 to 2016 were systematically reviewed.
Journal ArticleDOI
Case definitions for acute hepatitis C virus infection: a systematic review.
TL;DR: Although a single case definition for recent HCV is not warranted, a degree of standardization within specific study categories would enable improved cross-study comparison and more uniform evaluation of HCV prevention and management strategies.
Journal Article
Needle stick injuries in nurses at a tertiary health care facility
Iram Manzoor,Seema Daud,Norren Rahat Hashmi,Hira Sardar,Mirza Shaharyar Babar,Abdul Rahman,Madiha Malik +6 more
TL;DR: Needle stick injury is the most important occupational health hazard in nurses with alarmingly high rates and screening of nurses after needle stick injury and promotion of safety measures against it should be greatly encouraged.
Journal ArticleDOI
Hepatitis C virus viremic rate in the Middle East and North Africa: Systematic synthesis, meta-analyses, and meta-regressions
Manale Harfouche,Hiam Chemaitelly,Silva P. Kouyoumjian,Sarwat Mahmud,Karima Chaabna,Zaina Al-Kanaani,Laith J. Abu-Raddad +6 more
TL;DR: Though there is extensive variation in study-specific measures of HCV viremic rate, pooled mean estimates are similar regardless of risk population or subpopulation, country/subregion, HCV antibody prevalence in the background population, or sex.
Journal Article
Needle-stick injury: a rising bio-hazard.
TL;DR: Dental practitioners were at high risk of getting Needle Stick Injuries in dental offices because there was lack of practice of universal precautions.
References
More filters
Journal ArticleDOI
Timing of interferon therapy and sources of infection in patients with acute hepatitis C
Kei Ogata,Tatsuya Ide,Ryukichi Kumashiro,Hiromitsu Kumada,Hiroshi Yotsuyanagi,Kiwamu Okita,Yoshihiro Akahane,Shuichi Kaneko,Hirohito Tsubouchi,Eiji Tanaka,Hisataka Moriwaki,Shuhei Nishiguchi,Shinichi Kakumu,Masashi Mizokami,Shiro Iino,Michio Sata +15 more
TL;DR: The authors' multicenter cooperative survey revealed that medical procedure was the most frequent source of infection in acute hepatitis C, and interferon treatment should be initiated within 24 weeks after onset of symptoms.
Related Papers (5)
Treatment of acute hepatitis C genotypes 1 and 4 with 8 weeks of grazoprevir plus elbasvir (DAHHS2): an open-label, multicentre, single-arm, phase 3b trial
Anne Boerekamps,Anja De Weggheleire,Guido E.L. van den Berk,F. N. Lauw,Mark A. A. Claassen,Dirk Posthouwer,Wouter F W Bierman,Sebastiaan J. Hullegie,Stephanie Popping,David A C M van de Vijver,Anthonius S. M. Dofferhoff,Gert Jan Kootstra,Eliane M. S. Leyten,Jan G den Hollander,Marjo E. E. van Kasteren,Robert Soetekouw,Heidi S. M. Ammerlaan,Janke Schinkel,Eric Florence,Joop E. Arends,Bart J. A. Rijnders +20 more