Open Access
From Basic Science to Clinical Applications
Timothy E. Foster,Brian L. Puskas,Bert R. Mandelbaum,Michael B. Gerhardt,Scott A. Rodeo,Santa Monica +5 more
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The article was published on 2009-01-01 and is currently open access. It has received 667 citations till now. The article focuses on the topics: Applied science.read more
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Bone grafts and biomaterials substitutes for bone defect repair: A review.
Wenhao Wang,Kelvin W.K. Yeung +1 more
TL;DR: The currently available bone grafts and bone substitutes as well as the biological and bio-inorganic factors for the treatments of bone defect are reviewed.
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The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
TL;DR: How the development of future treatments for central nervous system (CNS) disorders can take advantage of the intimate and mutual interactions of the gut microbiota with the brain by exploring the role of SCFAs in the regulation of neuro-immunoendocrine function is highlighted.
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Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors
Paola Romina Amable,Rosana Bizon Vieira Carias,Marcus Vinicius Telles Teixeira,Ítalo da Cruz Pacheco,Ronaldo J F C do Amaral,José Mauro Granjeiro,Radovan Borojevic +6 more
TL;DR: This study resulted in a consistent PRP preparation method that yielded a cytokine and growth factor pool from different donors with high reproducibility and its content characterization will allow us to understand and improve the clinical outcomes.
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Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis
Giuseppe Filardo,Elizaveta Kon,Roberto Buda,Antonio Timoncini,Alessandro Di Martino,Annarita Cenacchi,Pier Maria Fornasari,Sandro Giannini,Maurilio Marcacci +8 more
TL;DR: These findings indicate that treatment with PRP injections can reduce pain and improve knee function and quality of life with short-term efficacy, and further studies are needed to confirm these results and understand the mechanism of action.
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Platelet-rich plasma: a milieu of bioactive factors.
TL;DR: It is supported that more than just platelets are playing a role in clinical responses to PRP, and the clinical use can theoretically be matched to the pathology being treated in an effort to improve clinical efficacy.
References
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The roles of membrane microdomains (rafts) in T cell activation.
TL;DR: The role of membrane microdomains enriched in sphingolipids, cholesterol and glycosylphosphatidylinositol-anchored proteins play essential roles in T cell receptor (TCR) signaling as discussed by the authors.
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Platelet gel (AGF) fails to increase fusion rates in instrumented posterolateral fusions.
TL;DR: It was shown that platelet gel failed to enhance fusion rate when added to autograft in patients undergoing instrumented posterolateral spinal fusion, and the authors do not recommend the use of Platelet gel to supplement autologous bone graft during instrumented Posterolateral lumbar fusion.
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Use of growth factors to improve muscle healing after strain injury.
Channarong Kasemkijwattana,Jacques Menetrey,Patrick Bosch,George T. Somogyi,Morey S. Moreland,Freddie H. Fu,Boonsin Buranapanitkit,Simon Watkins,Johnny Huard +8 more
TL;DR: The authors first evaluated natural muscle healing after strain injuries and showed that muscle regeneration occurs in the early phase of healing but becomes impaired with time by the development of tissue fibrosis.
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Platelet gel and fibrin sealant reduce allogeneic blood transfusions in total knee arthroplasty
Peter A.M. Everts,Roger J.J. Devilee,C Brown Mahoney,M Eeftinck-Schattenkerk,Henk A. M. Box,Johannes T. A. Knape,A van Zundert +6 more
TL;DR: This study evaluated the efficacy of autologous platelet gel and fibrin sealant in unilateral TKA to reduce the need for blood transfusion during total knee arthroplasty.
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Treatment of muscle injuries by local administration of autologous conditioned serum: animal experiments using a muscle contusion model.
TL;DR: ELISA results on the ACS have shown that the elevations in FGF-2 and TGF-beta1 could be partly responsible for the accelerating effects on regeneration due to proliferative and chemotactic properties.