Open Access
From Basic Science to Clinical Applications
Timothy E. Foster,Brian L. Puskas,Bert R. Mandelbaum,Michael B. Gerhardt,Scott A. Rodeo,Santa Monica +5 more
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The article was published on 2009-01-01 and is currently open access. It has received 667 citations till now. The article focuses on the topics: Applied science.read more
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Bone grafts and biomaterials substitutes for bone defect repair: A review.
Wenhao Wang,Kelvin W.K. Yeung +1 more
TL;DR: The currently available bone grafts and bone substitutes as well as the biological and bio-inorganic factors for the treatments of bone defect are reviewed.
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The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
TL;DR: How the development of future treatments for central nervous system (CNS) disorders can take advantage of the intimate and mutual interactions of the gut microbiota with the brain by exploring the role of SCFAs in the regulation of neuro-immunoendocrine function is highlighted.
Journal ArticleDOI
Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors
Paola Romina Amable,Rosana Bizon Vieira Carias,Marcus Vinicius Telles Teixeira,Ítalo da Cruz Pacheco,Ronaldo J F C do Amaral,José Mauro Granjeiro,Radovan Borojevic +6 more
TL;DR: This study resulted in a consistent PRP preparation method that yielded a cytokine and growth factor pool from different donors with high reproducibility and its content characterization will allow us to understand and improve the clinical outcomes.
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Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis
Giuseppe Filardo,Elizaveta Kon,Roberto Buda,Antonio Timoncini,Alessandro Di Martino,Annarita Cenacchi,Pier Maria Fornasari,Sandro Giannini,Maurilio Marcacci +8 more
TL;DR: These findings indicate that treatment with PRP injections can reduce pain and improve knee function and quality of life with short-term efficacy, and further studies are needed to confirm these results and understand the mechanism of action.
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Platelet-rich plasma: a milieu of bioactive factors.
TL;DR: It is supported that more than just platelets are playing a role in clinical responses to PRP, and the clinical use can theoretically be matched to the pathology being treated in an effort to improve clinical efficacy.
References
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The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses.
Robert B. Clark,David Bishop-Bailey,Tatiana Estrada-Hernandez,Timothy Hla,Lynn Puddington,Steven J. Padula +5 more
TL;DR: The demonstration of the expression and function of PPARγ in T cells reveals a new level of immunoregulatory control for PPARs and significantly increases the role and importance of PParγ in Immunoregulation.
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Platelet-rich plasma : a review of biology and applications in plastic surgery
TL;DR: The authors describe platelet biology and its role in wound healing; the preparation, characterization, and use of platelet-rich plasma; and those applications in plastic surgery for which it may be useful.
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Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors α- and γ-mediated gene expression via liver fatty acid binding protein: A signaling path to the nucleus
TL;DR: In localization studies using laser-scanning microscopy, it is shown that L-FABP and PPARα colocalize in the nucleus of mouse primary hepatocytes and it is demonstrated that the observed interaction of both proteins is independent of ligand binding.
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The Use of Autologous Platelet-Rich Plasma (Platelet Gel) and Autologous Platelet-Poor Plasma (Fibrin Glue) in Cosmetic Surgery
TL;DR: Capillary bed bleeding was present in all cases and effectively sealed within 3 minutes following the application of platelet gel and fibrin glue, so as to maintain hemostasis during cosmetic surgical procedures.
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Platelet-derived growth factors enhance proliferation of human stromal stem cells.
Enrico Lucarelli,Amira Beccheroni,Davide Maria Donati,Luca Sangiorgi,Annarita Cenacchi,Anna M. Del Vento,Carolina Meotti,Annarosa Zambon Bertoja,Roberto Giardino,Pier Maria Fornasari,Mario Mercuri,Piero Picci +11 more
TL;DR: Results showed that PRP induced SSC proliferation, and cells expanded with 10% PRP can mineralize the extracellular matrix once PRP is withdrawn, which is sufficient to induce a marked cell proliferation.