Journal ArticleDOI
From natural product to marketed drug: the tiacumicin odyssey
William Erb,Jieping Zhu +1 more
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TLDR
The aim of this review is to present an overview of the chemistry and biology of tiacumicins since their discovery.About:
This article is published in Natural Product Reports.The article was published on 2013-01-01. It has received 69 citations till now.read more
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Natural product and natural product derived drugs in clinical trials
TL;DR: The next few years will be critical for NP-driven lead discovery, and a concerted effort is required to identify new biologically active pharmacophores and to progress these and existing compounds through pre-clinical drug development into clinical trials.
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Prospects for new antibiotics: a molecule-centered perspective
TL;DR: This work brings a molecule-centered perspective to the questions of where will new scaffolds come from, when will chemogenetic approaches yield useful new antibiotics and what existing bacterial targets merit contemporary re-examination.
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Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles
Xufen Yu,Dianqing Sun +1 more
TL;DR: The primary goal of this review is to summarize currently used macrocyclic drugs, highlight the therapeutic potential of this underexplored drug class and outline the general synthetic methodologies for the synthesis of macrocycles.
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Current Applications of Suzuki–Miyaura Coupling Reaction in The Total Synthesis of Natural Products: An update
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Clostridium difficile Drug Pipeline: Challenges in Discovery and Development of New Agents
TL;DR: The current drug discovery pipeline is reviewed, including both small molecule and biologic therapies, and highlights the challenges associated with in vitro and in vivo models of C. difficile infection for drug screening and lead optimization.
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Journal ArticleDOI
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
TL;DR: Experimental and computational approaches to estimate solubility and permeability in discovery and development settings are described in this article, where the rule of 5 is used to predict poor absorption or permeability when there are more than 5 H-bond donors, 10 Hbond acceptors, and the calculated Log P (CLogP) is greater than 5 (or MlogP > 415).
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Natural Products as Sources of New Drugs over the Last 25 Years
David J. Newman,Gordon M. Cragg +1 more
TL;DR: This review is an updated and expanded version of two prior reviews that were published in this journal in 1997 and 2003 and is able to identify only one de novo combinatorial compound approved as a drug in this 25 plus year time frame.
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Prokaryotes: The unseen majority
TL;DR: The number of prokaryotes and the total amount of their cellular carbon on earth are estimated to be 4-6 x 10(30) cells and 350-550 Pg of C (1 Pg = 10(15) g), respectively, which is 60-100% of the estimated total carbon in plants.
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Fidaxomicin versus Vancomycin for Clostridium difficile Infection
Thomas J. Louie,Mark A. Miller,Kathleen M. Mullane,Karl Weiss,Arnold Lentnek,Yoav Golan,Sherwood L. Gorbach,Pamela Sears,Youe-Kong Shue +8 more
TL;DR: Fidaxomicin was associated with a significantly lower rate of recurrence of C. difficile infection associated with non–North American Pulsed Field type 1 strains and the adverse-event profile was similar for the two therapies.
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A Comparison of Vancomycin and Metronidazole for the Treatment of Clostridium difficile–Associated Diarrhea, Stratified by Disease Severity
TL;DR: The findings suggest that metronidazole and vancomycin are equally effective for the treatment of mild CDAD, but vancomYcin is superior for treating patients with severe CDAD.