Functional heterogeneity of immune defenses in molluscan oysters Crassostrea hongkongensis revealed by high-throughput single-cell transcriptome.
Reads0
Chats0
TLDR
Wang et al. as discussed by the authors used single-cell transcriptome profiling (scRNA-seq) to map the hemocyte and assess its heterogeneity in a molluscan oyster Crassostrea hongkongensis.About:
This article is published in Fish & Shellfish Immunology.The article was published on 2022-01-01 and is currently open access. It has received 12 citations till now. The article focuses on the topics: Biology & Transcriptome.read more
Citations
More filters
Journal ArticleDOI
Highly Sensitive and Specific Responses of Oyster Hemocytes to Copper Exposure: Single-Cell Transcriptomic Analysis of Different Cell Populations.
Jie Meng,Wen-Xiong Wang +1 more
TL;DR: The results provided the first mRNA expression profile of hemocytes in oysters and revealed the heterogeneity responses under Cu exposure and revealed granulocyte was the most important responsive cell type and displayed heterogeneity responses of its two subtypes.
Journal ArticleDOI
Bivalve Haemocyte Subpopulations: A Review
TL;DR: This review summarises the major and most recent findings in classification and functional characterisation of the main haemocyte types of bivalve molluscs.
Journal ArticleDOI
The characterization of an agranulocyte-specific marker (CgCD9) in the Pacific oyster Crassostrea gigas.
Miren Dong,Weilin Wang,Lingling Wang,Yu Liu,Youwen Ma,Meijia Li,Hai-peng Liu,Kejian Wang,Linsheng Song +8 more
TL;DR: In this paper , a homologue of CD9 (designed as CgCD9) was found to be highly expressed in agranulocytes of oyster C. gigas.
Journal ArticleDOI
Interaction between nanomaterials and the innate immune system across evolution
Diana Boraschi,Laura Canesi,Damjana Drobne,Birgit Kemmerling,Annalisa Pinsino,Petra Procházková +5 more
TL;DR: In this paper , the major effector cells of innate immunity, the phagocytes, and their major sensing receptors, Toll-like receptors (TLRs), for assessing the modes of successful versus pathological interaction between ENMs and host defences.
Journal ArticleDOI
Comparison of the Single-Cell Immune Landscape of Testudines from Different Habitats
TL;DR: In this paper , the authors compared the composition, function, and differentiation trajectories of peripheral immune cells in testudines (Chelonia mydas, Trachemys scripta elegans, Chelonoidis carbonaria, and Pelodiscus sinensis) from different habitats using the single-cell RNA sequencing (scRNA-seq) technique.
References
More filters
Journal ArticleDOI
Comprehensive Integration of Single-Cell Data.
Tim Stuart,Andrew Butler,Paul J. Hoffman,Christoph Hafemeister,Efthymia Papalexi,William M. Mauck,Yuhan Hao,Marlon Stoeckius,Peter Smibert,Rahul Satija +9 more
TL;DR: A strategy to "anchor" diverse datasets together, enabling us to integrate single-cell measurements not only across scRNA-seq technologies, but also across different modalities.
Journal ArticleDOI
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis
Miguel A. Sanjuan,Christopher P. Dillon,Stephen W.G. Tait,Simon Moshiach,Frank C. Dorsey,Samuel Connell,Masaaki Komatsu,Keiji Tanaka,John L. Cleveland,Sebo Withoff,Douglas R. Green +10 more
TL;DR: It is shown that a particle that engages TLRs on a murine macrophage while it is phagocytosed triggers the autophagosome marker LC3 to be rapidly recruited to the phagosome in a manner that depends on theAutophagy pathway proteins ATG5 and ATG7; this process is preceded by recruitment of beclin 1 and phosphoinositide-3-OH kinase activity.
Journal ArticleDOI
Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cells
TL;DR: Results support a key role for autophagy in mediating ssRNA virus detection and interferon-α secretion by pDCs and suggest that cytosolic replication intermediates of viruses serve as pathogen signatures recognized by TLR7.
Journal ArticleDOI
MAPK phosphatases--regulating the immune response.
TL;DR: The properties, function and regulation of MKPs during immune responses are discussed, highlighting the central role of this phosphatase in immune regulation.
Journal ArticleDOI
Autophagy Is an Essential Component of Drosophila Immunity against Vesicular Stomatitis Virus
TL;DR: Autophagy played a direct antiviral role against the mammalian viral pathogen vesicular stomatitis virus in the model organism Drosophila and the antiviral response was controlled by the phosphatidylinositol 3-kinase-Akt-signaling pathway, which normally regulates autophagy in response to nutrient availability.