Journal ArticleDOI
G-CSF administration results in thrombocytopenia by inhibiting the differentiation of hematopoietic progenitors into megakaryocytes.
TLDR
The results reveal that G-CSF administration causes thrombocytopenia mainly by inhibiting the differentiation of common myeloid progenitor and megakaryotic erythroid progenitors into megakARYocytes and platelet formation but not through enhancing activation of platelets or endothelial cells and following platelet consumption.About:
This article is published in Biochemical Pharmacology.The article was published on 2019-11-01. It has received 5 citations till now. The article focuses on the topics: Hematopoietic stem cell transplantation & Hematopoietic stem cell.read more
Citations
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Journal ArticleDOI
Contrasting Immunopathogenic and Therapeutic Roles of Granulocyte Colony-Stimulating Factor in Cancer
TL;DR: It is shown that stringently controlled prophylactic administration of recombinant (r) G-CSF is now a widely practiced strategy in medical oncology to prevent, and in some cases treat, chemotherapy-induced severe neutropenia.
Journal ArticleDOI
G-CSF: A vehicle for communication between trophoblasts and macrophages which may cause problems in recurrent spontaneous abortion.
Peng Gao,Ying Zha,Lijie Wei,Xuan Zhou,Shenglan Zhu,Huiting Zhang,Xuan Gao,Yi-ya Jiang,Yuting Chen,Jiaqi Li,Jingyi Zhang,Jun Yu,Shaoshuai Wang,Haiyi Liu,Lin Feng +14 more
TL;DR: Granulocyte-colony stimulating factor (G-CSF) exerts a protective effect on pregnancy and its absence may lead to pregnancy failure in half of patients with recurrent spontaneous abortion (RSA) as mentioned in this paper .
Journal ArticleDOI
A wearable gamma radiation-responsive granulocyte colony-stimulating factor microneedle system protecting against ionizing radiation-induced injury.
Xiangyang Ju,Lin Zhu,Xiaohui Liang,Bochuan Yuan,Minshu Li,Shen Hu,Pingtian Ding,Lina Du,Junwang Guo,Yiguang Jin +9 more
TL;DR: Wang et al. as mentioned in this paper developed a G-CSF wearable system (GWS) consisting of a commercial microchip, a temperature sensor, a gamma-ray detection sensor, and a flexible heater.
Journal ArticleDOI
The effect of G-CSF used after allogeneic hematopoietic stem cell transplantation on engraftment times and platelet suspension replacement numbers.
Ahmet Sarici,Mehmet Ali Erkurt,Irfan Kuku,Emin Kaya,Ilhami Berber,Soykan Bicim,Emine Hidayet,Ahmet Ihsan Kaya,M. F. Keser,Ömer Faruk Bahçecioğlu,Ayşe Uysal +10 more
TL;DR: In this article , the effect of granulocyte colony stimulating factor (G-CSF) on platelet engraftment after allogeneic hematopoietic stem cell transplantation (HSCT) was investigated.
Journal ArticleDOI
An "impossible" harvest-GCSF-induced immune thrombocytopenia in an autologous stem cell transplant recipient with multiple myeloma.
Jyotsna Kapoor,Vishvdeep Khushoo,Ambar Garg,Faran Naim,Niharika Bhatia,Bhaarat Folbs,Pallavi Mehta,Rayaz Ahmed,Narendra Agrawal,Dinesh Bhurani,Sumeet Prakash Mirgh +10 more
References
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Journal ArticleDOI
Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group
Francesco Rodeghiero,Roberto Stasi,Terry Gernsheimer,Marc Michel,Drew Provan,Donald M. Arnold,James B. Bussel,Douglas B. Cines,Beng H. Chong,Nichola Cooper,Bertrand Godeau,Klaus Lechner,Maria Gabriella Mazzucconi,Robert McMillan,Miguel A. Sanz,Paul Imbach,Victor S. Blanchette,Thomas Kühne,Marco Ruggeri,James N. George +19 more
TL;DR: An International Working Group of recognized expert clinicians convened a 2-day structured meeting to define standard terminology and definitions for primary ITP and its different phases and criteria for the grading of severity, and clinically meaningful outcomes and response.
Journal ArticleDOI
Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma
John F. DiPersio,Edward A. Stadtmauer,Auayporn Nademanee,Ivana N. Micallef,Patrick J. Stiff,Jonathan L. Kaufman,Richard T. Maziarz,Chitra Hosing,Stefan Fruehauf,Mitchell E. Horwitz,Dennis L. Cooper,Gary Bridger,Gary Calandra +12 more
TL;DR: Plerixafor and G- CSF were well tolerated, and significantly more patients collected the optimal CD34(+) cell/kg target for transplantation earlier compared with G-CSF alone.
Journal ArticleDOI
Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles
Robert Flaumenhaft,James R. Dilks,Jennifer L. Richardson,Eva C. Alden,Sunita Patel-Hett,Sunita Patel-Hett,Elisabeth M. Battinelli,Giannoula Klement,Giannoula Klement,Martha Sola-Visner,Joseph E. Italiano,Joseph E. Italiano +11 more
TL;DR: Results indicate that direct production by megakaryocytes represents a physiologic means to generate circulating platelet microparticles.
Journal ArticleDOI
Treatment of normal individuals with granulocyte-colony-stimulating factor: donor experiences and the effects on peripheral blood CD34+ cell counts and on the collection of peripheral blood stem cells.
TL;DR: G‐CSF has been used in patients to increase the level of circulating hematopoietic progenitors but the kinetics of mobilization of peripheral blood stem cells (PBSCs), the optimum dose schedule and the incidence and nature of adverse reactions in normal individuals are not completely defined.
Journal ArticleDOI
Higher mortality after allogeneic peripheral-blood transplantation compared with bone marrow in children and adolescents: the Histocompatibility and Alternate Stem Cell Source Working Committee of the International Bone Marrow Transplant Registry.
Mary Eapen,Mary M. Horowitz,John P. Klein,Richard E. Champlin,Fausto R. Loberiza,Olle Ringdén,John E. Wagner +6 more
TL;DR: These data suggest poorer outcomes after PBSC compared with BM transplantation in children after adjusting for relevant risk factors, and prospective clinical trials are required to determine their appropriate role.