Journal ArticleDOI
Gamma-aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues
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TLDR
GABA, a major inhibitory neurotransmitter of mammalian central nervous system, is found in a wide range of organisms, from prokaryotes to vertebrates, and is also present in a variety of circulating cells, including platelets and lymphocytes.About:
This article is published in Comparative Biochemistry and Physiology Part A: Physiology.The article was published on 1995-10-01. It has received 180 citations till now. The article focuses on the topics: gamma-Aminobutyric acid & Glutamate decarboxylase.read more
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UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL INSTITUTO DE CIÊNCIAS BÁSICAS DA SAÚDE PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS BIOLÓGICAS: BIOQUÍMICA ENVOLVIMENTO DO SISTEMA GABAérgico NAS ALTERAÇÕES COMPORTAMENTAIS, ELETRENCEFALOGRÁFICAS E NEUROQUÍMICAS INDUZIDAS PELA INJEÇÃO DE METILMALONATO NO VENTRÍCULO DE RATOS
TL;DR: This study investigates the involvement of GABAergic mechanisms in the convulsions induced by methylmalonic acid, an endogenous convulsing compound that accumulates in methyl malonic acidemia.
El sistema de inhibición GABAérgico implicado en la regulación de la ingesta alimentaria y obesidad GABAergic inhibition system involved in the regulation of food intake and obesity
TL;DR: The involvement of GABA out of the CNS not well understood, but apparently has an important role in paracrine signaling, autocrine and endocrine; these functions have shown benefits in the regulation of obesity, hyperglycemia and hypertension.
The role of E-2-hexenal and γ-amino butyric acid in plant defense responses
TL;DR: Green Leaf Volatiles, C6 molecules, which are very quickly produced and/or emitted upon herbivory or pathogen infection by almost every green plant play an important role in plant defenses and should be considered as co-protagonists in the play between plant and their attackers.
Journal ArticleDOI
Evaluation of Analytes Characterized with Potential Protective Action after Rat Exposure to Lead
Ivan Liakh,Darya Harshkova,Anastasiya Pauliukavets,Vladimir Sheibak,Tomasz Bączek,Natalia Miękus +5 more
TL;DR: In this article, a liquid chromatography (LC)-based method was used to illustrate the changes of amino acid (AA) and biogenic amine (BA) profiles observed in chosen immune and nervous systems rat tissues after Pb intoxication.
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Journal ArticleDOI
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase.
Steinunn Baekkeskov,Henk-Jan Aanstoot,Stephan Christgai,Annette Reetz,Michele Solimena,Marilia Cascalho,Franco Folli,Hanne Richter-Olesen,Pietro De Camilli +8 more
TL;DR: The pancreatic islet β-cell autoantigen of relative molecular mass 64,000 (64K), which is a major target of autoantibodies associated with the development of insulin-dependent diabetes mel-litus (IDDM), has been identified as glutamic acid decarboxylase, the biosynthesizing enzyme of the inhibitory neurotransmitter GABA.
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Two genes encode distinct glutamate decarboxylases.
TL;DR: The brain contains two forms of the GABA synthetic enzyme glutamate decarboxylase (GAD), which differ in molecular size, amino acid sequence, antigenicity, cellular and subcellular location, and interaction with the GAD cofactor pyridoxal phosphate.
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Molecular biology of GABAA receptors.
Richard W. Olsen,Allan J. Tobin +1 more
TL;DR: Subpopulations of GABAA receptors with different cellular and regional locations show differential sensitivity to GABA, to modulators like steroids, to physiological regulation, to disease processes, and to pharmacological manipulation by drugs such as benzodiazepines.
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Two Forms of the γ‐Aminobutyric Acid Synthetic Enzyme Glutamate Decarboxylase Have Distinct Intraneuronal Distributions and Cofactor Interactions
TL;DR: It is suggested that the relative levels of apo‐GAD65 and holo‐ GAD65 in synaptic terminals may couple GABA production to neuronal activity.
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Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms
Monique Esclapez,Niranjala J.K. Tillakaratne,Daniel L. Kaufman,Allan J. Tobin,Carolyn R. Houser +4 more
TL;DR: The findings suggest that the two isoforms of GAD are present in most classes of GABA neurons but that they are not similarly distributed within the neurons.