Journal ArticleDOI
Gamma-aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues
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TLDR
GABA, a major inhibitory neurotransmitter of mammalian central nervous system, is found in a wide range of organisms, from prokaryotes to vertebrates, and is also present in a variety of circulating cells, including platelets and lymphocytes.About:
This article is published in Comparative Biochemistry and Physiology Part A: Physiology.The article was published on 1995-10-01. It has received 180 citations till now. The article focuses on the topics: gamma-Aminobutyric acid & Glutamate decarboxylase.read more
Citations
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Book ChapterDOI
GABA and GABA receptors in the central nervous system and other organs.
TL;DR: In addition to its role in neural development, GABA appears to be involved in a wide variety of physiological functions in tissues and organs outside the brain.
Journal ArticleDOI
Modulation of practice-dependent plasticity in human motor cortex
TL;DR: It is proposed that changes in GABA activity may be instrumented to modulate plasticity purposefully; for instance, to enhance plastic change and recovery of function after a lesion in neurological patients.
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Mitochondrial succinic-semialdehyde dehydrogenase of the γ-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants
TL;DR: A role for the GABA shunt is established in preventing the accumulation of reactive oxygen intermediates and cell death, which appears to be essential for plant defense against environmental stress.
Journal ArticleDOI
Calmodulin binding to glutamate decarboxylase is required for regulation of glutamate and GABA metabolism and normal development in plants.
TL;DR: It is concluded that CaM binding to GAD is essential for the regulation of GABA and glutamate metabolism, and that regulation of GAD activity is necessary for normal plant development.
Journal ArticleDOI
The bZIP transcription factor MoAP1 mediates the oxidative stress response and is critical for pathogenicity of the rice blast fungus Magnaporthe oryzae.
Min Guo,Yue Chen,Yan Du,Yanhan Dong,Wang Guo,Su Zhai,Haifeng Zhang,Suomeng Dong,Zhengguang Zhang,Yuanchao Wang,Ping Wang,Xiaobo Zheng +11 more
TL;DR: It is found that MoAP1 is highly expressed in conidia and during invasive hyphal growth, and regulates transcriptions of M. oryzae that are important in the growth, development, and pathogenicity of the fungus.
References
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BookDOI
GABA outside the CNS
TL;DR: The GABAergic System in Human Female Genital Organs and Neurotransmitter Amino Acids as Modulators of Biological Processes of Spermatozoa are studied.
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Problems in GABA Research from Brain to Bacteria: edited by Yasuhiro Okada and Eugene Roberts, Excerpta Medica, 1982. Dfl 260.00 (xx + 443 pages) ISBN 0 444 90236 8
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Immunocytochemical localisation of GABA in endocrine cells of the rat entero-pancreatic system
TL;DR: The occurence of GABA‐containing cells in the rat entero‐pancreatic system was investigated by using anti‐GABA‐glutaraldehyde antibodies at the light and electron microscope level and GABA immunoreactivity was detected in certain endocrine cell types, suggesting a possible interaction with this amino acid.
Journal ArticleDOI
Isolation and characterization of recombinant mitochondrial 4-aminobutyrate aminotransferase.
TL;DR: The isolated precursor of 4-aminobutyrate aminotransferase contains pyridoxal 5-phosphate and exhibits catalytic activity comparable to that of the mature enzyme (20 units/mg).