Journal ArticleDOI
Gamma-aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues
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TLDR
GABA, a major inhibitory neurotransmitter of mammalian central nervous system, is found in a wide range of organisms, from prokaryotes to vertebrates, and is also present in a variety of circulating cells, including platelets and lymphocytes.About:
This article is published in Comparative Biochemistry and Physiology Part A: Physiology.The article was published on 1995-10-01. It has received 180 citations till now. The article focuses on the topics: gamma-Aminobutyric acid & Glutamate decarboxylase.read more
Citations
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Book ChapterDOI
GABA and GABA receptors in the central nervous system and other organs.
TL;DR: In addition to its role in neural development, GABA appears to be involved in a wide variety of physiological functions in tissues and organs outside the brain.
Journal ArticleDOI
Modulation of practice-dependent plasticity in human motor cortex
TL;DR: It is proposed that changes in GABA activity may be instrumented to modulate plasticity purposefully; for instance, to enhance plastic change and recovery of function after a lesion in neurological patients.
Journal ArticleDOI
Mitochondrial succinic-semialdehyde dehydrogenase of the γ-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants
TL;DR: A role for the GABA shunt is established in preventing the accumulation of reactive oxygen intermediates and cell death, which appears to be essential for plant defense against environmental stress.
Journal ArticleDOI
Calmodulin binding to glutamate decarboxylase is required for regulation of glutamate and GABA metabolism and normal development in plants.
TL;DR: It is concluded that CaM binding to GAD is essential for the regulation of GABA and glutamate metabolism, and that regulation of GAD activity is necessary for normal plant development.
Journal ArticleDOI
The bZIP transcription factor MoAP1 mediates the oxidative stress response and is critical for pathogenicity of the rice blast fungus Magnaporthe oryzae.
Min Guo,Yue Chen,Yan Du,Yanhan Dong,Wang Guo,Su Zhai,Haifeng Zhang,Suomeng Dong,Zhengguang Zhang,Yuanchao Wang,Ping Wang,Xiaobo Zheng +11 more
TL;DR: It is found that MoAP1 is highly expressed in conidia and during invasive hyphal growth, and regulates transcriptions of M. oryzae that are important in the growth, development, and pathogenicity of the fungus.
References
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Journal ArticleDOI
The amphicrine pancreatic cell line AR42J: a model system for combined studies on exocrine and endocrine secretion
TL;DR: AR42J cells represent the first amphicrine pancreatic cell line with the combined expression of exocrine and neuroendocrine secretory organelles, both of which follow a regulated secretory pathway in response to various secretory stimuli.
Journal ArticleDOI
Uptake and catabolism of γ-aminobutyric acid by the isolated perfused rat liver
Peter Ferenci,Peter Ferenci,Thomas Stehle,Thomas Stehle,Josef Ebner,Josef Ebner,Rainer Schmid,Rainer Schmid,Dieter Häussinger,Dieter Häussinger +9 more
TL;DR: Serum concentrations of γ-aminobutyric acid (GABA) are increased in liver failure, possibly because of decreased hepatic GABA catabolism, but the magnitude of the observed impairment would be insufficient to account for a 10-fold increase in such levels.
Book ChapterDOI
The GABAergic System in Human Female Genital Organs
TL;DR: It has been recently shown that γ-aminobutyric acid and its related enzymes, i.e., glutamate decarboxylase (GAD) and GABAtransaminase (GABA-T), are present in the female genitale tract of various mammals at higher levels than in most other organs, at least in the rat.
Book ChapterDOI
The Role of GABA in the Peripheral Nervous System
C. Tanaka,K. Taniyama +1 more
TL;DR: Evidence from physiological, neurochemical, and morphological studies suggests that GABA acts on peripheral tissues not only as a neurotransmitter in enteric and parasympathetic nervous systems, but additionally as a hormone.
Journal ArticleDOI
Crystallization and preliminary X-ray analysis of γ-aminobutyric acid transaminase
Zora Marković-Housley,Tilman Schirmer,Bruno Fol,Johan N. Jansonius,Daniela De Biase,Robert A. John +5 more
TL;DR: In this paper, an α2 dimeric enzyme of pig liver was crystallized by the vapour diffusion method with polyethylene glycol as precipitant, and the crystals are monoclinic, space group P21, unit cell dimensions a = 82.1 A, b = 230.0 A, c = 70.3 A, β = 123.9 ° and diffract to 2.5 A resolution.