Journal ArticleDOI
Gamma-aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues
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TLDR
GABA, a major inhibitory neurotransmitter of mammalian central nervous system, is found in a wide range of organisms, from prokaryotes to vertebrates, and is also present in a variety of circulating cells, including platelets and lymphocytes.About:
This article is published in Comparative Biochemistry and Physiology Part A: Physiology.The article was published on 1995-10-01. It has received 180 citations till now. The article focuses on the topics: gamma-Aminobutyric acid & Glutamate decarboxylase.read more
Citations
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Book ChapterDOI
GABA and GABA receptors in the central nervous system and other organs.
TL;DR: In addition to its role in neural development, GABA appears to be involved in a wide variety of physiological functions in tissues and organs outside the brain.
Journal ArticleDOI
Modulation of practice-dependent plasticity in human motor cortex
TL;DR: It is proposed that changes in GABA activity may be instrumented to modulate plasticity purposefully; for instance, to enhance plastic change and recovery of function after a lesion in neurological patients.
Journal ArticleDOI
Mitochondrial succinic-semialdehyde dehydrogenase of the γ-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants
TL;DR: A role for the GABA shunt is established in preventing the accumulation of reactive oxygen intermediates and cell death, which appears to be essential for plant defense against environmental stress.
Journal ArticleDOI
Calmodulin binding to glutamate decarboxylase is required for regulation of glutamate and GABA metabolism and normal development in plants.
TL;DR: It is concluded that CaM binding to GAD is essential for the regulation of GABA and glutamate metabolism, and that regulation of GAD activity is necessary for normal plant development.
Journal ArticleDOI
The bZIP transcription factor MoAP1 mediates the oxidative stress response and is critical for pathogenicity of the rice blast fungus Magnaporthe oryzae.
Min Guo,Yue Chen,Yan Du,Yanhan Dong,Wang Guo,Su Zhai,Haifeng Zhang,Suomeng Dong,Zhengguang Zhang,Yuanchao Wang,Ping Wang,Xiaobo Zheng +11 more
TL;DR: It is found that MoAP1 is highly expressed in conidia and during invasive hyphal growth, and regulates transcriptions of M. oryzae that are important in the growth, development, and pathogenicity of the fungus.
References
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Journal ArticleDOI
Human monoclonal islet cell antibodies from a patient with insulin-dependent diabetes mellitus reveal glutamate decarboxylase as the target antigen.
Wiltrud Richter,Josef Endl,Thomas Eiermann,Michael Brandt,Rosemarie Kientsch-Engel,Charles Thivolet,Herbert Jungfer,Werner A. Scherbaum +7 more
TL;DR: Six islet cell-specific B-cell lines, originating from a patient with newly diagnosed IDDM, could be stabilized on a monoclonal level and MICA 1-6 were shown to recognize four distinct antigenic epitopes in islets, revealing glutamate decarboxylase as the predominant target antigen of cytoplasmic isletcell autoantibodies in a patients with newly diagnosis IDDM.
Book ChapterDOI
The Nature of γ-Aminobutyric Acid
TL;DR: The first reference to γ-aminobutyric acid (GABA) appeared in 1883 when the synthesis of a compound named Piperidinsaure was reported as discussed by the authors.
Journal ArticleDOI
GABA-transaminases of human brain and peripheral tissues--kinetic and molecular properties.
Helen L. White,Takao L. Sato +1 more
TL;DR: Kinetic experiments with 4‐aminobutyrate‐2‐ketoglutarate transaminase (GABA‐T), partially purified from human brain tissue, supported a Bi Bi Ping‐Pong type of enzyme mechanism in which the enzyme oscillates between forms bound to pyridoxal phosphate and pyrIDoxamine phosphate.
Journal ArticleDOI
Association of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region.
Michele Solimena,D. Aggujaro,C Muntzel,Ronald Dirkx,Margaret H. Butler,P De Camilli,Adrian Hayday +6 more
TL;DR: A chimeric protein in which the 88 N-terminal amino acids of GAD-67 were replaced by the 83 N- terminal amino acid of Gad-65 was targeted to the Golgi complex, indicating that the N-Terminal region of G AD-65 contains a targeting signal sufficient for directing the remaining portion of the molecule, highly similar in GAD -65 and GAD_67, to the golgi complex-associated structures.
Journal ArticleDOI
Serum levels of gamma-aminobutyric-acid-like activity in acute and chronic hepatocellular disease.
TL;DR: Findings are compatible with the hypothesis that the GABA neurotransmitter system is involved in the pathogenesis of hepatic encephalopathy in man and particularly high levels were detected in patients with cirrhosis 12-16 h after gastrointestinal haemorrhages.