Journal ArticleDOI
Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology.
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TLDR
Investigation of the gastric myenteric and submucosal plexuses in 150 microm cryosections and 8 microm paraffin sections from five autopsy individuals found alpha-synuclein immunoreactive inclusions were found in neurons of the subMucosal Meissner plexus, whose axons could provide the first link in an uninterrupted series of susceptible neurons that extend from the enteric to the central nervous system.About:
This article is published in Neuroscience Letters.The article was published on 2006-03-20. It has received 1147 citations till now. The article focuses on the topics: Enteric nervous system & Nervous system.read more
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The Microbiota-Gut-Brain Axis
John F. Cryan,Kenneth J. O’Riordan,Caitlin S. M. Cowan,Kiran V. Sandhu,Thomaz F.S. Bastiaanssen,Marcus Boehme,Martín Gabriel Codagnone,Sofia Cussotto,Christine Fülling,Anna V. Golubeva,Katherine E. Guzzetta,Minal Jaggar,Caitriona M. Long-Smith,Joshua M. Lyte,Jason A. Martin,Alicia Molinero-Perez,Gerard M. Moloney,Emanuela Morelli,Enrique Morillas,Rory C. O'Connor,Joana S Cruz-Pereira,Veronica L. Peterson,Kieran Rea,Nathaniel L. Ritz,Eoin Sherwin,Simon Spichak,Emily M. Teichman,Marcel van de Wouw,Ana Paula Ventura-Silva,Shauna E. Wallace-Fitzsimons,Niall P. Hyland,Gerard Clarke,Timothy G. Dinan +32 more
TL;DR: Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.
Journal ArticleDOI
Gut microbiota are related to Parkinson's disease and clinical phenotype.
Filip Scheperjans,Velma T. E. Aho,Pedro A. B. Pereira,Kaisa Koskinen,Lars Paulin,Eero Pekkonen,Elena Haapaniemi,Seppo Kaakkola,Johanna Eerola-Rautio,Marjatta Pohja,Esko Kinnunen,Kari Murros,Petri Auvinen +12 more
TL;DR: The findings suggest that the intestinal microbiome is altered in PD and is related to motor phenotype, and the suitability of the microbiome as a biomarker is warranted.
Journal ArticleDOI
Rotenone, Paraquat, and Parkinson’s Disease
Caroline M. Tanner,Freya Kamel,G. Webster Ross,Jane A. Hoppin,Samuel M. Goldman,Monica Korell,Connie Marras,Grace S. Bhudhikanok,Meike Kasten,Anabel R. Chade,Kathleen Comyns,Marie Richards,Cheryl Meng,Benjamin Priestley,Hubert H. Fernandez,Franca Cambi,David M. Umbach,Aaron Blair,Dale P. Sandler,J. William Langston +19 more
TL;DR: PD was positively associated with two groups of pesticides defined by mechanisms implicated experimentally—those that impair mitochondrial function and those that increase oxidative stress—supporting a role for these mechanisms in PD pathophysiology.
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100 years of Lewy pathology
TL;DR: The relevance of Lewy's discovery 100 years ago for the current understanding of PD and related disorders is reviewed.
Journal ArticleDOI
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice.
Kelvin C. Luk,Victoria M. Kehm,Bin Zhang,Patrick O’Brien,John Q. Trojanowski,Virginia M.-Y. Lee +5 more
TL;DR: Synthetic a-Synuclein fibrils injected into the brain spread far beyond the injection site and are sufficient to accelerate Parkinson’s disease–like pathology in mice.
References
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Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TL;DR: The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.
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Staging of brain pathology related to sporadic Parkinson’s disease
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Alpha-synuclein in Lewy bodies.
Maria Grazia Spillantini,Marie L. Schmidt,Virginia M.-Y. Lee,John Q. Trojanowski,Ross Jakes,Michel Goedert +5 more
TL;DR: Strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for α-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease, indicates that the LewY bodies from these two diseases may have identical compositions.
Journal ArticleDOI
Stages in the development of Parkinson’s disease-related pathology
TL;DR: Parkinsons disease is a multisystem disorder that involves only a few predisposed nerve cell types in specific regions of the human nervous system as discussed by the authors, where the intracerebral formation of abnormal proteinaceous Lewy bodies and Lewy neurites advances in a topographically predictable sequence.
Journal ArticleDOI
Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen.
TL;DR: The here hypothesized mechanism offers one possible explanation for the sequential and apparently uninterrupted manner in which vulnerable brain regions, subcortical grays and cortical areas become involved in idiopathic Parkinson's disease.