Journal ArticleDOI
Geminiviruses: Models for Plant DNA Replication, Transcription, and Cell Cycle Regulation
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TLDR
The goal of this review is to summarize recent research addressing geminivirus DNA replication and its integration with transcriptional and cell cycle regulatory processes.Abstract:
Geminiviruses have small, single-stranded DNA genomes that replicate through double-stranded intermediates in the nuclei of infected plant cells. Viral double-stranded DNA also assembles into minichromosomes and is transcribed in infected cells. Geminiviruses encode only a few proteins for their replication and transcription and rely on host enzymes for these processes. However, most plant cells, which have exited the cell cycle and undergone differentiation, do not contain the replicative enzymes necessary for viral DNA synthesis. To overcome this barrier, geminiviruses induce the accumulation of DNA replication machinery in mature plant cells, most likely by modifying cell cycle and transcriptional controls. In animals, several DNA viruses depend on host replication and transcription machinery and can alter their hosts to create an environment that facilitates efficient viral replication. Analysis of these viruses and their proteins has contributed significantly to our understanding of DNA replication, transcription, and cell cycle regulation in mammalian cells. Geminiviruses have the same potential for plant systems. Plants offer many advantages for these types of studies, including ease of transformation, well-defined cell populations and developmental programs, and greater tolerance of cell cycle perturbation and polyploidy. Our knowledge of the molecular and cellular events that mediate geminivirus infection has increased significantly during recent years. The goal of this review is to summarize recent research addressing geminivirus DNA replication and its integration with transcriptional and cell cycle regulatory processes.read more
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Journal ArticleDOI
Top 10 plant viruses in molecular plant pathology
Karen-Beth G. Scholthof,Scott Adkins,Henryk Czosnek,Peter Palukaitis,Emmanuel Jacquot,Thomas Hohn,Barbara Hohn,Keith Saunders,Thierry Candresse,Paul Ahlquist,Cynthia Hemenway,Gary D. Foster +11 more
TL;DR: A short review on each virus of the Top 10 list and its importance is presented, with the intent of initiating discussion and debate amongst the plant virology community, as well as laying down a benchmark, as it will be interesting to see in future years how perceptions change and which viruses enter and leave the Top10.
Journal ArticleDOI
Geminiviruses: masters at redirecting and reprogramming plant processes
TL;DR: This Review describes the current knowledge of how geminiviruses interact with their plant hosts and the functional consequences of these interactions.
Journal ArticleDOI
Exploiting chinks in the plant's armor: evolution and emergence of geminiviruses
TL;DR: The geminiviruses represent a family of DNA viruses that has circumvented these impediments to emerge as one of the most successful viral pathogens, causing severe economic losses to agricultural production worldwide.
Journal ArticleDOI
Identification of dna components required for induction of cotton leaf curl disease.
Rob W. Briddon,Shahid Mansoor,Ian D. Bedford,M.S. Pinner,Keith Saunders,John Stanley,Y. Zafar,Kauser A. Malik,Peter G. Markham +8 more
TL;DR: A single-stranded DNA molecule approximately 1350 nucleotides in length is identified which, when coinoculated with the begomovirus to cotton, induces symptoms typical of CLCuD, including vein swelling, vein darkening, leaf curling, and enations.
Journal ArticleDOI
Four plant Dicers mediate viral small RNA biogenesis and DNA virus induced silencing
Todd Blevins,Rajendran Rajeswaran,Padubidri V. Shivaprasad,Daria Beknazariants,Azeddine Si-Ammour,Hyun Sook Park,Franck Vazquez,Dominique Robertson,Frederick Meins,Thomas Hohn,Thomas Hohn,Mikhail M. Pooggin +11 more
TL;DR: This work highlights the complexity of virus interaction with host silencing pathways and suggests that DCL multiplicity helps mediate plant responses to diverse viral infections.