Journal ArticleDOI
General Theory of Chromosome Structure and Gene Activation in Eukaryotes
TLDR
This simple theory provides a function for non-histone proteins and an explanation for the large size of eukaryotic genomes, repetitive sequences in DNA, HnRNA and “processing” of nuclear RNA.Abstract:
This simple theory provides a function for non-histone proteins and an explanation for the large size of eukaryotic genomes, repetitive sequences in DNA, HnRNA and “processing” of nuclear RNA.read more
Citations
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Journal ArticleDOI
What is a gene, post-ENCODE? History and updated definition
Mark Gerstein,Joel Rozowsky,Deyou Zheng,Jiang Du,Jan O. Korbel,Olof Emanuelsson,Zhengdong D. Zhang,Sherman M. Weissman,Michael Snyder +8 more
TL;DR: This definition side-steps the complexities of regulation and transcription by removing the former altogether from the definition and arguing that final, functional gene products (rather than intermediate transcripts) should be used to group together entities associated with a single gene.
Journal ArticleDOI
A system for mapping DNA sequences in the chromosomes of Drosophila melanogaster.
TL;DR: Individual segments of the chromosomal DNA in D. melanogaster were isolated, and the sequences they contain were analyzed for repetition and mapped within the polytene chromosomes, which are not compatible with tandem repetition models for the chromomere.
Journal ArticleDOI
Studies on metal ions-DNA interactions: specific behaviour of reiterative DNA sequences.
I. Sissoeff,J. Grisvard,E Guille +2 more
Book ChapterDOI
Cell Size and Nuclear DNA Content in Vertebrates
TL;DR: Cell size, the nucleocytoplasmic ratio, and the DNA content of the nucleus are mutually interdependent and it is justifiable to use the data on one of these features for the approximate determination of the others.
Journal ArticleDOI
Effects of 5-bromo-2'-deoxyuridine and dimethyl sulfoxide on properties and structure of chromatin.
Jean-Numa Lapeyre,Isaac Bekhor +1 more
TL;DR: The results are compatible with the hypothesis that BrdUrd promotes localized changes in chromatin condensation, probably by modification of chromosomal protein-DNA interactions, although the possibility that chromosomal proteins are modified, is not at present ruled out.
References
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Journal ArticleDOI
Repeated Sequences in DNA
Roy J. Britten,D. E. Kohne +1 more
TL;DR: Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms and used in medicine, science, and engineering.
Journal ArticleDOI
Identification of human chromosomes by DNA-binding fluorescent agents
Torbjörn Caspersson,Torbjörn Caspersson,Lore Zech,Lore Zech,Clas B. Johansson,Clas B. Johansson,E.J. Modest,E.J. Modest +7 more
TL;DR: A convenient measuring technique has been developed for the rapid and accurate recording of fluorescence patterns in human metaphase chromosomes that should be particularly valuable for the identification of chromosomes 4–5 and the individual types in the 6–12 group.
Journal ArticleDOI
Visualization of Nucleolar Genes
O. L. Miller,Barbara R. Beatty +1 more
TL;DR: The presence of extrachromosomal nucleoli in amphibian oocytes has permitted isolation and electron microscopic observation of the genes coding for ribosomal RNA precursor molecules.
Journal ArticleDOI
The cost of natural selection
TL;DR: It is suggested that, in horotelic evolution, the mean time taken for each gene substitution is about 300 generations, which accords with the observed slowness of evolution.
Journal ArticleDOI
Organ-specific restriction of transcription in mammalian chromatin
J Paul,R.Stewart Gilmour +1 more
TL;DR: It is concluded that histones can mask DNA in chromatin and prevent it from acting as a template, but this effect is nonspecific.