Journal ArticleDOI
Generation and Synthetic Application of Trifluoromethyl Diazomethane Utilizing Continuous Flow Technologies
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TLDR
To avoid storage and transportation of the hazardous compound, a representative downstream process in a packed-bed reactor yielding highly functionalized building blocks was developed.About:
This article is published in Organic Letters.The article was published on 2016-02-23. It has received 68 citations till now. The article focuses on the topics: Diazo & Diazomethane.read more
Citations
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Journal ArticleDOI
The Hitchhiker's Guide to Flow Chemistry
TL;DR: This review introduces readers to the basic principles and fundamentals of flow chemistry and critically discusses recent flow chemistry accounts.
Journal ArticleDOI
Continuous flow biocatalysis.
TL;DR: This Review explores continuous flow biocatalysts with emphasis on new technology, enzymes, whole cells, co-factor recycling, and immobilization methods for the synthesis of pharmaceuticals, value-added chemicals, and materials.
Journal ArticleDOI
Greener and Sustainable Trends in Synthesis of Organics and Nanomaterials.
TL;DR: Trends in greener and sustainable process development during the past 25 years are abridged involving the use of alternate energy inputs, photochemistry, and greener reaction media as applied to synthesis of organics and nanomaterials.
Journal ArticleDOI
Continuous flow chemistry: where are we now? Recent applications, challenges and limitations
Faith M. Akwi,Paul Watts +1 more
TL;DR: A general outlook of the changing face of chemical synthesis is provided in this article through recent applications of continuous flow processing in both industry and academia to put into perspective the current position of Continuous flow processing, either as an alternative or potential combinatory technology for batch processing.
Journal ArticleDOI
Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry
TL;DR: A combination of simplified and automated systems are discussed, demonstrating how flow chemistry solutions can be tailored to fit the specific needs of a project.
References
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Journal ArticleDOI
Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001-2011).
Jiang Wang,María Sánchez-Roselló,José Luis Aceña,Carlos del Pozo,Alexander E. Sorochinsky,Alexander E. Sorochinsky,Alexander E. Sorochinsky,Santos Fustero,Vadim A. Soloshonok,Vadim A. Soloshonok,Hong Liu +10 more
TL;DR: Introduced to the Market in the Last Decade (2001−2011) Jiang Wang,† María Sańchez-Rosello,́‡,§ Jose ́ Luis Aceña, Carlos del Pozo,‡ and Hong Liu.
BookDOI
Fluorine in medicinal chemistry and chemical biology
TL;DR: This book discusses applications of fluorinated amino acids and peptides to chemical biology and pharmacology, and recent Advances in the Syntheses of Fluorinated Amino Acids.
Journal ArticleDOI
Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents
Journal ArticleDOI
Continuous‐Flow Technology—A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients
TL;DR: This Review discusses recent literature examples of continuous-flow organic synthesis where hazardous reactions or extreme process windows have been employed, with a focus on applications of relevance to the preparation of pharmaceuticals.