Journal ArticleDOI
Generation of Cells With Hodgkin's and Reed-Sternberg Phenotype Through Downregulation of CD99 (Mic2)
Soon Ha Kim,Soon Ha Kim,Soon Ha Kim,Eun Young Choi,Eun Young Choi,Eun Young Choi,Young Kee Shin,Young Kee Shin,Young Kee Shin,Tae Jin Kim,Tae Jin Kim,Tae Jin Kim,Doo Hyun Chung,Doo Hyun Chung,Doo Hyun Chung,Sung Ik Chang,Sung Ik Chang,Sung Ik Chang,Noe Kyeong Kim,Noe Kyeong Kim,Noe Kyeong Kim,Seong Hoe Park,Seong Hoe Park,Seong Hoe Park +23 more
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TLDR
It is suggested that CD99 molecules play a crucial role in regulating functions and morphology of cells through a Rac-Rho signaling pathway and that the loss of CD99 expression is a significant molecular event to generate H-RS cells.About:
This article is published in Blood.The article was published on 1998-12-01. It has received 65 citations till now. The article focuses on the topics: Cellular differentiation & Reed–Sternberg cell.read more
Citations
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Hodgkin disease: Hodgkin andReed-Sternberg cells picked from histological sections showclonal immunoglobulin gene rearrangements andappear tobederived fromB cells atvarious stages ofdevelopment
TL;DR: In this article, the authors isolated HRScells by micromanipulation fromhistologicalsections of three cases ofHodgkinlymphoma and analyzed individual cells for immunoglobulin variable (V) gene rear-rangements by PCR.
Journal ArticleDOI
Epstein-Barr virus-associated lymphoproliferative disorders.
Sherif Rezk,Lawrence M. Weiss +1 more
TL;DR: A review of EBV-associated lymphoproliferative disorders, dividing them into B-cell, T/NK-cell and HIV-related lymphoplastic disorders, is presented in this article.
Journal ArticleDOI
Coexpression of BMI-1 and EZH2 polycomb group genes in Reed-Sternberg cells of Hodgkin's disease.
Frank M. Raaphorst,Folkert J. van Kemenade,Tjasso Blokzijl,Elly Fieret,Karien M. Hamer,David P. E. Satijn,Arie P. Otte,Chris J.L.M. Meijer +7 more
TL;DR: Observations suggests that Hodgkin's disease is associated with coexpression of BMI-1 and EZH2 in HRS cells.
Journal ArticleDOI
Epstein–Barr virus-associated Hodgkin's lymphoma
TL;DR: Increased knowledge of the virus’ role in the basic biology of HL may generate novel therapeutic strategies for EBV‐positive HL and the presence of EBV•latent antigens in the malignant HL cells may represent a target for cellular immunotherapy.
Journal ArticleDOI
Molecular biology of Hodgkin lymphoma
TL;DR: Inactivating mutations in the TNFAIP3 tumor suppressor gene, encoding a negative regulator of NF-kappaB activity, were recently identified in about 40% of patients with classical HL.
References
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Journal ArticleDOI
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more
TL;DR: It is reported here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell periphery, filopodia, in addition to stress fibers, and rho controls the assembly of focal adhesion complexes.
Journal ArticleDOI
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.
TL;DR: It is proposed that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin and that growth factors act through rac to stimulate this rho-dependent response.
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Rho GTPases and signaling networks
TL;DR: The Rho GTPases form a subgroup of the Ras superfamily of 20- to 30-kD GTP-binding proteins that have been shown to regulate a wide spectrum of cellular functions, and some of the more recent exciting findings hinting at novel, unanticipated functions of the RhoGTPases are summarized.
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The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells.
Harald Stein,D Y Mason,Johannes Gerdes,N O'Connor,J. S. Wainscoat,Gorm Pallesen,K C Gatter,B Falini,Georges Delsol,Hilmar Lemke,R Schwarting,Karl Lennert +11 more
TL;DR: Results obtained indicate that Ki-1 antigen is an inducible lymphoid-associated molecule that identifies a group of hitherto poorly characterized normal and neoplastic large lymphoid cells in Hodgkin's disease and Disorders in which only a minority of cells express Ki- 1 antigen probably represent lesions in whichonly some of the abnormal cells have transformed into an "activation state.
Journal ArticleDOI
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
TL;DR: It is proposed that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin and that growth factors act through rac to stimulate this rho-dependent response.