Genetic influences on insulinemia in normotensive twins
Krzysztof Narkiewicz,Marzena Chrostowska,G Kuchta,Radosław Szczęch,A Welz,Andrzej Rynkiewicz,Wieslawa Lysiak-Szydlowska,Ryszard Pawłowski,Barbara Krupa-Wojciechowska +8 more
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The data indicate that genetic factors are important determinants of insulinemia in normal subjects, independent of body mass index.About:
This article is published in American Journal of Hypertension.The article was published on 1997-04-01 and is currently open access. It has received 16 citations till now. The article focuses on the topics: Twin study & Heritability.read more
Citations
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Journal ArticleDOI
The Genetic Dissection of Complex Traits in a Founder Population
TL;DR: The present study demonstrates the feasibility of genomewide association studies for QTL mapping among the Hutterites, however, even in this young founder population that has extensive linkage disequilibrium, map densities <<5 cM may be required to detect all major QTLs.
Journal ArticleDOI
Epidemiology of risk factors for hypertension: implications for prevention and therapy.
TL;DR: The role of stress in the aetiology of high blood pressure is still under investigation, but recent clinical experimental and epidemiological data have shed light on how stress could be related to hypertension.
Journal ArticleDOI
Clustering of metabolic abnormalities in obese individuals: the role of genetic factors.
Olavi Ukkola,Claude Bouchard +1 more
TL;DR: Gene-gene interaction effects between markers of the α2A, β2 and β3 adrenergic receptor genes on components of the metabolic syndrome have been described and genetic factors also seem to modify the responsiveness of metabolic syndrome features to endurance training.
Journal ArticleDOI
Heritability of plasma leptin levels: a twin study.
Krzysztof Narkiewicz,Radosław Szczęch,Mikolaj Winnicki,Marzena Chrostowska,Ryszard Pawłowski,Wieslawa Lysiak-Szydlowska,Ian Choe,Masahiko Kato,William I. Sivitz,Barbara Krupa-Wojciechowska,Virend K. Somers +10 more
TL;DR: Genetic factors are major determinants of plasma leptin levels in humans and may account for as much as half of the variance in leptin levels.
Journal ArticleDOI
The metabolic syndrome: an emerging risk state for cardiovascular disease
TL;DR: The World Health Organisation and the National Cholesterol Education Programme’s Adult Treatment Panel III (NCEP-ATP III) have outlined specific diagnostic criteria for the diagnosis of the metabolic syndrome to help in the Identification of this syndrome in clinical practice.
References
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Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
TL;DR: The correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
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Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease
TL;DR: In summary, insulin resistance appears to be a syndrome that is associated with a clustering of metabolic disorders, including non-insulin-dependent diabetes mellitus, obesity, hypertension, lipid abnormalities, and atherosclerotic cardiovascular disease.
Journal ArticleDOI
Insulin resistance in essential hypertension
Eleuterio Ferrannini,G. Buzzigoli,Riccardo C. Bonadonna,Maria Antonietta Giorico,M. Oleggini,L. Graziadei,Roberto Pedrinelli,L. S. Brandi,Stefano Bevilacqua +8 more
TL;DR: Results provide preliminary evidence that essential hypertension is an insulin-resistant state and insulin resistance involves glucose but not lipid or potassium metabolism, is located in peripheral tissues but not the liver, is limited to nonoxidative pathways of intracellular glucose disposal, and is directly correlated with the severity of hypertension.
Journal ArticleDOI
Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.
TL;DR: It is concluded that insulin resistance and/or hyperinsulinemia are present in the majority of hypertensives, constitute a common pathophysiologic feature of obesity, glucose intolerance, and hypertension, possibly explaining their ubiquitous association, and may be linked to the increased peripheral vascular resistance of hypertension, which is putatively related to elevated intracellular sodium concentration.
Book
Hypertension : pathophysiology, diagnosis, and management
John H. Laragh,Barry M. Brenner +1 more
TL;DR: This book discusses Hypertension: Definitions, Natural Histories, and Consequences, and the role of Dietary Protein in Hypertensive Disease: The Japanese Experience: Clinical Implications, which focused on the case of Yukio Yamori.