Journal ArticleDOI
Glucocorticoid and mineralocorticoid receptors in gut mucosa.
Lynne Pressley,John W. Funder +1 more
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TLDR
Binding sites for tritiated aldosterone, with affinity characteristics appropriate for physiological mineralocorticoid receptors, were demonstrated in duodenum, jejunum, ileum and colon, and no similar sites could be shown in the mucosa of the gastric antrum.Abstract:
Both glucocorticoid and mineralocorticoid hormones are known to be involved in the physiology and pathophysiology of the gastrointestinal tract. Studies on the mechanism of action of steroid hormones indicate an initial obligatory step of binding to stereospecific receptor proteins in the cytoplasm of target tissue cells. Mucosal cells from the gastrointestinal tract of adrenalectomized, gonadectomized rats contain cytoplasmic glucocorticoid receptors which bind tritiated dexamethasone with an affinity (Kdiss4C) of approximately 10(-8)M. The concentration of glucocorticoid receptors per unit cytoplasmic protein is in order duodenum greater than jejunum greater than ileum=stomach greater than colon, and their affinity for steroid hormones is in order dexamethasone greater than corticosterone greater than deoxycorticosterone=aldosterone. No glucocorticoid receptors could be demonstrated in esophageal mucosal cells. Binding sites for tritiated aldosterone, with affinity characteristics appropriate for physiological mineralocorticoid receptors, were demonstrated in duodenum, jejunum, ileum and colon. No similar sites could be shown in the mucosa of the gastric antrum.read more
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Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor
Jeffrey L. Arriza,Jeffrey L. Arriza,Cary Weinberger,Gail M. Cerelli,Thomas M Glaser,Barbara Handelin,David E. Housman,Ronald M. Evans +7 more
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Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory.
TL;DR: It is suggested that acute stress, by activating glucocorticoid receptors, increases the trafficking and function of NMDARs and AMPARs through SGK/Rab4 signaling, which leads to the potentiated synaptic transmission, thereby facilitating cognitive processes mediated by the PFC.
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The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology
Say Viengchareun,Damien Le Menuet,Laetitia Martinerie,Mathilde Munier,Laurent Pascual-Le Tallec,Marc Lombès +5 more
TL;DR: The structure, molecular mechanism of action and transcriptional regulation mediated by MR are described, emphasizing the most recent developments at the cellular and molecular level.
Journal ArticleDOI
Characterization of rat brain aldosterone receptors reveals high affinity for corticosterone.
TL;DR: It is concluded that the high affinity aldosterone receptor of rat brain, which had been identified in preliminary studies as a mineralocorticoid receptor, may bind either corticosterone or ald testosterone in vivo.