Journal ArticleDOI
Glucocorticoid-induced osteoporosis: mechanisms, management, and future perspectives
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TLDR
Recent advances in the understanding of the mechanisms underlying the physiology and pathophysiology of glucocorticoid action on the skeleton are highlighted and present and future management strategies for glucoc Corticoid-induced osteoporosis are discussed.About:
This article is published in The Lancet Diabetes & Endocrinology.The article was published on 2013-09-01. It has received 160 citations till now. The article focuses on the topics: Mesenchymal cell differentiation.read more
Citations
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Complications of Cushing's syndrome: state of the art
Rosario Pivonello,Andrea M. Isidori,Maria Cristina De Martino,John Newell-Price,John Newell-Price,Beverly M. K. Biller,Annamaria Colao +6 more
TL;DR: Cushing's syndrome is a serious endocrine disease caused by chronic, autonomous, and excessive secretion of cortisol, which is associated with increased mortality and impaired quality of life because of the occurrence of comorbidities as discussed by the authors.
Journal ArticleDOI
A phase 2 study of Chronocort, a modified-release formulation of hydrocortisone, in the treatment of adults with classic congenital adrenal hyperplasia.
Ashwini Mallappa,Ninet Sinaii,Parag Kumar,Martin J. Whitaker,Lori Ann Daley,Dena Digweed,David Eckland,Carol Van Ryzin,Lynnette K. Nieman,Wiebke Arlt,Wiebke Arlt,Richard J. Ross,Richard J. Ross,Deborah P. Merke +13 more
TL;DR: Twice-daily Chronocort approximates physiologic cortisol secretion, and was well tolerated and effective in controlling androgen excess in adults with CAH.
Journal ArticleDOI
Alcohol: A Simple Nutrient with Complex Actions on Bone in the Adult Skeleton
TL;DR: Light to moderate alcohol consumption is generally reported to be beneficial, resulting in higher bone mineral density (BMD) and reduced age-related bone loss, whereas heavy drinking is generally associated with decreased BMD, impaired bone quality, and increased fracture risk.
Journal ArticleDOI
Fracture risk in oral glucocorticoid users: a Bayesian meta-regression leveraging control arms of osteoporosis clinical trials
M. A. Amiche,Jordan M. Albaum,Mina Tadrous,Mina Tadrous,Petros Pechlivanoglou,Linda E. Lévesque,Jonathan D. Adachi,Suzanne M. Cadarette +7 more
TL;DR: It is suggested that fracture incidence among oral GC users may be more common than previously estimated and Optimizing GC-induced osteoporosis management during early exposure to GC is essential to prevent fractures.
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Advances in the medical treatment of Cushing's syndrome
Richard A Feelders,John Newell-Price,Rosario Pivonello,Lynnette K. Nieman,Leo J. Hofland,André Lacroix +5 more
TL;DR: This work summarises the drug therapies for various forms of Cushing's syndrome and focuses on emerging drugs and drug targets that have the potential for new and effective tailor-made pharmacotherapy for patients with Cushed's syndrome.
References
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Journal ArticleDOI
ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult
Sharon A. Hunt,William T. Abraham,Marshall H. Chin,Arthur M. Feldman,Gary S. Francis,Theodore G. Ganiats,Mariell Jessup,Marvin A. Konstam,Donna Mancini,Keith Michl,John A. Oates,Peter S. Rahko,Marc A. Silver,Lynne W. Stevenson,Clyde W. Yancy,Elliott M. Antman,Sidney C. Smith,Cynthia D. Adams,Jeffrey L. Anderson,David P. Faxon,Valentin Fuster,Jonathan L. Halperin,Loren F. Hiratzka,Alice K. Jacobs,Rick A. Nishimura,Joseph P. Ornato,Richard L. Page,Barbara Riegel +27 more
TL;DR: This document summarizes current capabilities, research and operational priorities, and plans for further studies that were established at the 2015 USGS workshop on quantitative hazard assessments of earthquake-triggered landsliding and liquefaction.
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Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis.
Robert M. Neer,Claude D. Arnaud,Jose R. Zanchetta,Richard L. Prince,Gregory A Gaich,Jean-Yves Reginster,Anthony B. Hodsman,Erik Fink Eriksen,Sophia Ish-Shalom,Harry K. Genant,Ouhong Wang,Bruce H. Mitlak +11 more
TL;DR: Treatment of postmenopausal osteoporosis with parathyroid hormone decreases the risk of vertebral and nonvertebral fractures; increases vertebral, femoral, and total-body bone mineral density; and is well tolerated.
Journal ArticleDOI
ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure).
TL;DR: The American College of Cardiology (ACC)/American Heart Association (AHA) Task Force on Practice Guidelines regularly reviews existing guidelines to determine when an update or full revision is needed.
Journal ArticleDOI
Interventions for preventing falls in older people living in the community
Lesley D Gillespie,Mary Clare Robertson,William J Gillespie,Catherine Sherrington,Simon Gates,Lindy Clemson,Sarah E Lamb +6 more
TL;DR: These interventions were more effective in people at higher risk of falling, including those with severe visual impairment, and home safety interventions appear to be more effective when delivered by an occupational therapist.
Journal ArticleDOI
Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial
Bruce Ettinger,Dennis M. Black,Bruce H. Mitlak,Ronald Keith Knickerbocker,Thomas Nickelsen,Harry K. Genant,Claus Christiansen,Pierre D. Delmas,Jose R. Zanchetta,J. A. Stakkestad,Claus C. Glüer,Kathryn A. Krueger,Fredric J. Cohen,Stephen Eckert,Kristine E. Ensrud,Louis V. Avioli,Paul Lips,Steven R. Cummings +17 more
TL;DR: The Multiple Outcomes of Raloxifene Evaluation (MORE) study as mentioned in this paper evaluated the effect of raloxion hydrochloride therapy on risk of vertebral and non-vertebral fractures.