Journal ArticleDOI
Factors affecting fertilization: endometrial placental protein 14 reduces the capacity of human spermatozoa to bind to the human zona pellucida*†
TLDR
Placental protein 14 produced a potent, fast, and dose-dependent inhibition of binding of human spermatozoa to the human ZP without affecting other prefertilization events (i.e., hyperactivated motility or AR); the detrimental effect on sperm-zona interaction seems to be specific for this endometrial epithelial protein.About:
This article is published in Fertility and Sterility.The article was published on 1995-02-01. It has received 198 citations till now. The article focuses on the topics: Sperm motility & Acrosome reaction.read more
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Insulin-like Growth Factor Binding Protein-1: Recent Findings and New Directions
TL;DR: Similarities between the hlGFBP-1 and phosphoenolpyruvate kinase (PEPCK) promoters, including regions conferring insulin, glucocorticoid, and cyclic adenosine-monophosphate responses, are consistent with the previous hypothesis that IGF BP-1 is involved in regulation of glucose metabolism.
Journal ArticleDOI
Structural analysis of the oligosaccharides derived from glycodelin, a human glycoprotein with potent immunosuppressive and contraceptive activities.
Anne Dell,Howard R. Morris,Richard L. Easton,Maria Panico,Manish S. Patankar,Sergio Oehninger,Riitta Koistinen,Hannu Koistinen,Markku Seppälä,Gary F. Clark +9 more
TL;DR: The potent inhibitory effect of glycodelin on initial human sperm-zona pellucida binding is consistent with previous suggestion that this cell adhesion event requires a selectin-like adhesion process and raises the possibility that a convergence between immune and gamete recognition processes may have occurred in the types of carbohydrate ligands recognized in the human.
Journal ArticleDOI
The human endometrium as a fertility-determining factor
TL;DR: The endometrium shall be considered as an important fertility-determining factor and therapeutic options to improve endometrial function and dysfunction should be developed in near future.
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Endometrial stromal cells regulate epithelial cell growth in vitro: a new co-culture model
TL;DR: In this article, a co-culture model was proposed to investigate the cellular interactions between endometrial stromal and epithelial cells and their environment and to understand the molecular basis for the regulation of normal growth and differentiation of cells within complex tissues such as the endometrium.
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Glycodelin: A Major Lipocalin Protein of the Reproductive Axis with Diverse Actions in Cell Recognition and Differentiation
TL;DR: Along with being an epithelial differentiation marker, glycodelin appears to play a role in glandular morphogenesis, as transfection of gly codelin cDNA into a glyCodelin-negative breast cancer cells resulted in formation of gland-like structures, restricted proliferation, and induction of other epithelial markers.
References
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Journal ArticleDOI
Two simple methods for detecting acrosome‐reacted human sperm
TL;DR: Two methods for detecting acrosome reactions of human sperm at the light microscopic level are described, rapid, give similar results, and detect an increase in acrosomes reactions following exposure to the ionophore A23187.
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The hemizona assay (HZA): development of a diagnostic test for the binding of human spermatozoa to the human hemizona pellucida to predict fertilization potential * † ‡
Lani J. Burkman,Charles C. Coddington,Daniel R. Franken,Thinus F. Kruger,Zev Rosenwaks,Gary D. Hodgen +5 more
TL;DR: Sperm from fertile men exhibited significantly higher binding capacity to hemizonae compared with sperm from men who had fertilization failure during in vitro fertilization (IVF) treatment, demonstrating that the HZA may be a useful diagnostic tool in male infertility evaluations.
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Suppression by human placental protein 14 of natural killer cell activity.
Norihiko Okamoto,Atsushi Uchida,K. Takakura,Yoshitaka Kariya,Hideharu Kanzaki,Leena Riittinen,Riitta Koistinen,Markku Seppälä,T. Mori +8 more
TL;DR: Results indicate that PP14 suppresses the function of NK cells, which might be involved in prevention of maternal immune rejection of fetus at the fetomaternal interface.
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The natural killer activity of peritoneal fluid lymphocytes is decreased in women with endometriosis.
TL;DR: In this paper, the local natural killer (local NK) activity of peritoneal fluid mononuclear cells (PFMC) was measured in 44 women who underwent a laparoscopy for infertility and/or pain at the University Hospital of Gasthuisberg, Leuven, Belgium.