Journal ArticleDOI
Glycosaminoglycan polymerization may enable osmotically inactive Na+ storage in the skin
Jens Titze,Mehdi Shakibaei,Markus Schafflhuber,Gundula Schulze-Tanzil,Markus Porst,Karl H. Schwind,Peter Dietsch,Karl F. Hilgers +7 more
TLDR
It is concluded that osmotically inactive skin Na(+) storage is an active process characterized by an increased GAG content in the reservoir tissue, and inhibition or disinhibition of GAG chain polymerization may regulate osmOTically inactive Na(+ storage.Abstract:
Osmotically inactive skin Na+ storage is characterized by Na+ accumulation without water accumulation in the skin. Negatively charged glycosaminoglycans (GAGs) may be important in skin Na+ storage....read more
Citations
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Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism
Agnes Machnik,Wolfgang Neuhofer,Jonathan Jantsch,Anke Dahlmann,Tuomas Tammela,Katharina Machura,Joon-Keun Park,F. X. Beck,Dominik N. Müller,Wolfgang Derer,Jennifer Goss,Agata Ziomber,Peter Dietsch,Hubertus Wagner,Nico van Rooijen,Armin Kurtz,Karl F. Hilgers,Kari Alitalo,Kai-Uwe Eckardt,Friedrich C. Luft,Dontscho Kerjaschki,Jens Titze +21 more
TL;DR: It is shown that a high-salt diet in rats leads to interstitial hypertonic Na+ accumulation in skin, resulting in increased density and hyperplasia of the lymphcapillary network and VEGFC is identified as an osmosensitive, hypertonicity-driven gene intimately involved in salt-induced hypertension.
Journal ArticleDOI
Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer
Helge Wiig,Melody A. Swartz +1 more
TL;DR: This review integrates the biophysical, biomechanical, and biological aspects of interstitial and lymph fluid and its transport in tissue physiology, pathophysiology, and immune regulation.
Journal ArticleDOI
Disorders of Plasma Sodium — Causes, Consequences, and Correction
TL;DR: This review considers the causes and consequences of an abnormal plasma sodium concentration and offers a framework for correcting it.
Journal ArticleDOI
Immune cells control skin lymphatic electrolyte homeostasis and blood pressure
Helge Wiig,Agnes Schröder,Wolfgang Neuhofer,Jonathan Jantsch,Christoph W. Kopp,Tine V. Karlsen,Michael Boschmann,Jennifer Goss,Maija Bry,Natalia Rakova,Anke Dahlmann,Sven Brenner,Olav Tenstad,Harri Nurmi,Eero Mervaala,Hubertus Wagner,F. X. Beck,Dominik N. Müller,Dontscho Kerjaschki,Friedrich C. Luft,David G. Harrison,Kari Alitalo,Jens Titze +22 more
TL;DR: The results suggest that the skin contains a hypertonic interstitial fluid compartment in which MPS cells exert homeostatic and blood pressure-regulatory control by local organization of interstitial electrolyte clearance via TONEBP and VEGFC/VEGFR3-mediated modification of cutaneous lymphatic capillary function.
Journal ArticleDOI
23Na Magnetic Resonance Imaging-Determined Tissue Sodium in Healthy Subjects and Hypertensive Patients
Christoph W. Kopp,Peter Linz,Anke Dahlmann,Matthias Hammon,Jonathan Jantsch,Dominik N. Müller,Roland E. Schmieder,Alexander Cavallaro,Kai-Uwe Eckardt,Michael Uder,Friedrich C. Luft,Jens Titze +11 more
TL;DR: 23Na magnetic resonance imaging could have utility in assessing the role of tissue Na+ storage for cardiovascular morbidity and mortality in longitudinal studies, and it is suggested that patients with refractory hypertension had increased tissueNa+ content, compared with normotensive controls.
References
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