Open AccessJournal Article
Green Tea Polyphenol Treatment to Human Skin Prevents Formation of Ultraviolet Light B-induced Pyrimidine Dimers in DNA
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TLDR
The data suggest that GTP may be used as a novel chemopreventive candidate and possible strategy to reduce UV-induced skin cancer risk in the human population.Abstract:
Cancer chemopreventive effects of polyphenols from green tea (GTP) in mouse models of photocarcinogenesis are established. The present study is extended from mouse model to human system in vivo to determine the effect of topical application of GTP to human individuals against UV light-induced DNA damage in the form of cyclobutane pyrimidine dimers (CPDs) in the skin. UVB-induced CPDs were detected by immunohistochemical technique using monoclonal antibodies to thymine dimers. With the gradual increase in UVB dose, both erythema response and CPD formation in the skin was increased. GTP treatment inhibited both UVB-induced erythema response as well as CPD formation. Topical treatment with GTP (approximately 1 mg/cm2 of skin area) 20 min before human buttock skin (sun-protected site) exposure to UVB inhibited CPD formation in epidermis by 81, 70, 60, and 60% at 0.5, 1.0, 2.0, and 4.0 minimal erythema dose of UV exposure, respectively. Treatment of human skin with varying doses of GTP (1-4 mg/2.5 cm2 of skin area) before a single dose of UVB exposure (4.0 minimal erythema dose) decreased dose dependently the formation of UVB-induced CPDs in both epidermis and dermis. The inhibition of UVB-induced CPDs by GTP treatment may be, at least in part, responsible for the inhibition of photocarcinogenesis. Our data suggest that GTP may be used as a novel chemopreventive candidate and possible strategy to reduce UV-induced skin cancer risk in the human population.read more
Citations
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Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions.
Jane V. Higdon,Balz Frei +1 more
TL;DR: The effects of tea and green tea catechins on biomarker of oxidative stress, especially oxidative DNA damage, appear very promising in animal models, but data on biomarkers of in vivo oxidative stress in humans are limited.
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Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms
TL;DR: It is suggested that polyphenols may favorably supplement sunscreens protection, and may be useful for skin diseases associated with solar UV radiation-induced inflammation, oxidative stress and DNA damage.
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Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals.
H-H. Sherry Chow,Yan Cai,Iman A. Hakim,James A. Crowell,Farah Shahi,Chris Brooks,Robert T. Dorr,Yukihiko Hara,David S. Alberts +8 more
TL;DR: It is safe for healthy individuals to take green tea polyphenol products in amounts equivalent to the EGCG content in 8-16 cups of green tea once a day or in divided doses twice a day for 4 weeks, and the pharmacokinetics of the conjugated metabolites of epigallocatechin and epicatechin were not affected by repeated green teapolyphenol treatment.
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Cutaneous photodamage, oxidative stress, and topical antioxidant protection
TL;DR: This scientific review summarizes what is known about how photodamage occurs; why sunscreens--the current gold standard of photoprotection--are inadequate; and how topical AOs help protect against skin cancer and photoaging changes.
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Dietary polyphenolic phytochemicals—promising cancer chemopreventive agents in humans? A review of their clinical properties
Sarah C. Thomasset,David P. Berry,Giuseppe Garcea,Timothy H. Marczylo,William P. Steward,Andreas J. Gescher +5 more
TL;DR: A review of pilot studies and trials with a cancer chemoprevention‐related rationale, in which either healthy individuals or patients with premalignant conditions or cancer received polyphenolic phytochemicals is presented.
References
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Journal ArticleDOI
Tea and Cancer
Chung S. Yang,Zhi-Yuan Wang +1 more
TL;DR: A critical review of the relationship between tea consumption and human cancer risk is provided, covering basic chemistry and biochemical activity of tea, epidemiologic investigations, and laboratory studies, as well as possible directions for future research.
Journal ArticleDOI
Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice.
TL;DR: It is shown that the delivery of lesion-specific DNA repair enzymes to living skin after UV irradiation is an effective tool for restoring immune function and this approach may be broadly applicable to preventing other alterations caused by DNA damage.
Journal ArticleDOI
Tea in chemoprevention of cancer
Santosh K. Katiyar,Hasan Mukhtar +1 more
TL;DR: Based on available information, epidemiologic and experimental studies are ongoing to draw the possible relationship between tea consumption and cancer causation and prevention and Appropriate strategies for future clinical chemoprevention trials to translate animal data to human cancer risk are warranted.
Journal Article
Inhibitory effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on ultraviolet B light-induced skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated SKH-1 mice.
Zhi Y. Wang,Mou-Tuan Huang,You-Rong Lou,Jian-Guo Xie,Kenneth R. Reuhl,Harold L. Newmark,Chi-Tang Ho,Chung S. Yang,Allan H. Conney +8 more
TL;DR: Administration of black tea was comparable to green tea as an inhibitor of UVB-induced skin carcinogenesis in DMBA-initiated SKH-1 mice.
Journal Article
Inhibitory effect of green tea in the drinking water on tumorigenesis by ultraviolet light and 12-O-tetradecanoylphorbol-13-acetate in the skin of SKH-1 mice.
Zhi Yuan Wang,Mou-Tuan Huang,Thomas Ferraro,Ching-Quo Wong,You-Rong Lou,Kenneth R. Reuhl,Michael J. Iatropoulos,Chung S. Yang,Allan H. Conney +8 more
TL;DR: Treatment of the animals with the green tea extract not only decreased the number of skin tumors but also decreased substantially the size of the tumors.