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Journal ArticleDOI

Growth and acid production by Lactobacillus (L.) delbrueckii in a dialysis culture system

Morton R. Friedman, +1 more
- 01 Nov 1970 - 
- Vol. 12, Iss: 6, pp 961-974
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TLDR
It has been shown that lactate inhibits growth after the log phase and that the maintenance of low lactate concentrations after this point permits higher specific growth rates and higher maximum cell concentrations.
Abstract
Growth and lactic acid production by L. delbrueckii was studied in a dialysis culture system and the inhibitory effect of lactate confirmed by removing lactate from the culture medium by dialysis. It has been shown that lactate inhibits growth after the log phase and that the maintenance of low lactate concentrations after this point permits higher specific growth rates and higher maximum cell concentrations. Acid production is also significantly higher in a dialysis culture system. Finally, a modification of the Luedeking‐Piret model, incorporating the lactate inhibition effect, is proposed.

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Citations
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Journal ArticleDOI

Ion Exchange for Product Recovery in Lactic Acid Fermentation

TL;DR: In this paper, the feasibility of ion exchange as a technique for product separation is investigated, and detailed equilibrium and kinetic data required for design and scale-up of the separation process have been obtained for this resin under conditions of relevance to the fermentation.
Journal ArticleDOI

Dialysis fermentation. II. Kinetic analysis of salicylic acid production via cell growth and maintenance

TL;DR: A kinetic analysis was made of the relationship between salicylate production from naphthalene and growth of Pseudomonas fluorescens in semicontinuous dialysis culture, finding that productivity and growth were correlated by the Luedeking‐Piret equation in an initial nondialysis period and in the early stages of dialysis fermentation, when specific growth rates exceeded.
Journal ArticleDOI

Kinetic study of electrodialysis of acetic acid and phosphate in fermentation broth

TL;DR: In this paper, the ion fluxes of acetic acid and phosphate in the electrodialysis of a model fermentation broth were examined using a solution of acid and potassium dihydrogenphosphate.
Journal ArticleDOI

Economic evaluation of a multicompartment bioreactor for ethanol production using in situ extraction of ethanol

TL;DR: In this article, the authors described a multicompartment reactor that can be used with yeast (Saccharomyces cerevisiae) for ethanol production from a starch hydrolysate, by separating a solvent layer (tri-normal-butylphosphate, or TBP) from a cell layer.

Integration of Bioreactor and Membrane Separation Processes: A Model Based Approach: Reverse Electro-Enhanced Dialysis process for lactic acid fermentation

TL;DR: In this paper, an integrated bioreactor and an electrically driven membrane separation process for lactic acid fermentation is investigated through a model based investigation of the individual units and the integrated system.
References
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Journal ArticleDOI

Limiting factors in the lactic fermentation

TL;DR: A microscopic count was used in order to avoid as far as possible the error introduced into the plate method by the tendency of the lactic streptococci to grow in pairs and chains.
Journal ArticleDOI

Dialysis Fermentor Systems for Concentrated Culture of Microorganisms.

TL;DR: Cell-mass production of Serratia marcescens was studied in dialysis systems in which growth was managed in a fermentor remote from, but connected by conduits and pumps with, a nutrient reservoir, believed to be adaptable to any desired scale of size.
Journal ArticleDOI

Penicillin production in corn steep media with continuous carbohydrate addition.

TL;DR: The work reported here presents the results of an investigation into the replacement of lactose by glucose or by sucrose in a corn steep liquor medium for the production of penicillin.
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