Journal ArticleDOI
Growth of Candida albicans hyphae
TLDR
The current understanding of the network of signal transduction pathways that monitors environmental cues to activate a programme of hypha-specific gene transcription, and the molecular processes that drive the highly polarized growth of hyphae are described.Abstract:
The fungus Candida albicans is often a benign member of the mucosal flora; however, it commonly causes mucosal disease with substantial morbidity and in vulnerable patients it causes life-threatening bloodstream infections. A striking feature of its biology is its ability to grow in yeast, pseudohyphal and hyphal forms. The hyphal form has an important role in causing disease by invading epithelial cells and causing tissue damage. This Review describes our current understanding of the network of signal transduction pathways that monitors environmental cues to activate a programme of hypha-specific gene transcription, and the molecular processes that drive the highly polarized growth of hyphae.read more
Citations
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Candida albicans pathogenicity mechanisms
TL;DR: This review presents an update on the current understanding of the pathogenicity mechanisms of this important human pathogen and reveals novel virulence mechanisms have recently been discovered.
Journal ArticleDOI
N-Acetylglucosamine Functions in Cell Signaling
TL;DR: The emerging roles of GlcNAc as an activator and mediator of cellular signaling in fungi, animals, and bacteria will be the focus of this paper.
Journal ArticleDOI
Development and regulation of single- and multi-species Candida albicans biofilms.
TL;DR: An overview of the processes involved in the formation of C. albicans biofilms is provided and the core transcriptional network that regulates biofilm development is discussed, which is an opportunistic pathogen that can cause severe, and often fatal, bloodstream infections.
Journal ArticleDOI
Candida albicans cell-type switching and functional plasticity in the mammalian host.
TL;DR: The characteristics of the classic cell types — yeast, hyphae, pseudohyphae and chlamydospores — as well as the newly identified yeast-like morphotypes are explored, highlighting emerging knowledge about the associations of these different morphotypes with different host niches and virulence potential.
References
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Journal ArticleDOI
Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study
Hilmar Wisplinghoff,Tammy Bischoff,Sandra M. Tallent,Harald Seifert,Richard P. Wenzel,Michael B. Edmond +5 more
TL;DR: The proportion of nosocomial BSIs due to antibiotic-resistant organisms is increasing in US hospitals, and in neutropenic patients, infections with Candida species, enterococci, and viridans group streptococci were significantly more common.
Journal ArticleDOI
Lifeact: a versatile marker to visualize F-actin
Julia Riedl,Alvaro H. Crevenna,Kai Kessenbrock,Jerry Haochen Yu,Dorothee Neukirchen,Michal Bista,Frank Bradke,Dieter E. Jenne,Tad A. Holak,Zena Werb,Michael Sixt,Roland Wedlich-Söldner +11 more
TL;DR: Lifeact, a 17-amino-acid peptide, is described, which stained filamentous actin (F-actin) structures in eukaryotic cells and tissues and in its chemically modified peptide form allowed visualization of actin dynamics in nontransfectable cells.
Journal ArticleDOI
Nonfilamentous C. albicans mutants are avirulent.
Hsiu-Jung Lo,Julia R. Köhler,Julia R. Köhler,Beth DiDomenico,David Loebenberg,Anthony Cacciapuoti,Gerald R. Fink +6 more
TL;DR: This Candida cph1/cph1 efg1/efg1 double mutant, locked in the yeast form, is avirulent in a mouse model.
Book
Candida and candidosis
TL;DR: A comprehensive and critical review of the medical and scientific literature on Candida infections by a leading authority in the field.
Journal ArticleDOI
Secular Trends in the Epidemiology of Nosocomial Fungal Infections in the United States, 1980–1990
TL;DR: Fungi are emerging as important nosocomial pathogens and control efforts should target fungal infections, especially fungemia, which has increased at all four major anatomic sites of infection.