Journal ArticleDOI
GSK3β is a checkpoint for TNF-α-mediated impaired osteogenic differentiation of mesenchymal stem cells in inflammatory microenvironments.
Xiangwei Kong,Yan Liu,Ruidong Ye,Bin Zhu,Yuan Zhu,Xianghui Liu,Chenghu Hu,Hailang Luo,Yongjie Zhang,Yin Ding,Yan Jin +10 more
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TLDR
GSK3β plays an obligatory role in the TNF-α-mediated inhibition of osteogenesis in MSCs and may provide a potential approach to bone regeneration in inflammatory microenvironments.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2013-11-01. It has received 70 citations till now. The article focuses on the topics: Periodontal ligament stem cells & Bone regeneration.read more
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Long noncoding RNA related to periodontitis interacts with miR-182 to upregulate osteogenic differentiation in periodontal mesenchymal stem cells of periodontitis patients.
TL;DR: Novel evidence is provided that this lncRNA-miRNA (microRNA) regulatory network has a significant role in osteogenic differentiation of pPDLSCs and that it has potential as a therapeutic target in mesenchymal stem cells during inflammation.
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The effects of tumour necrosis factor-α on bone cells involved in periodontal alveolar bone loss; osteoclasts, osteoblasts and osteocytes.
TL;DR: It is evident that managing the chronic inflammatory response in addition to the deregulated bone metabolism is required to improve periodontal and inflammatory bone loss treatments.
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Double-edged-sword effect of IL-1β on the osteogenesis of periodontal ligament stem cells via crosstalk between the NF-κB, MAPK and BMP/Smad signaling pathways.
TL;DR: It is shown for the first time that interleukin-1 β (IL-1β) has dual roles in the osteogenesis of PDLSCs at concentrations ranging from physiologically healthy levels to those found in chronic periodontitis, and crosstalk between NF-κB, MAPK and BMP/Smad signaling mediates this dual effect.
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Microenvironmental Views on Mesenchymal Stem Cell Differentiation in Aging
TL;DR: This review discusses the respective contribution of microenvironmental pathologic factors to age-related MSC dysfunction and proposes strategies to rescue differentiation disorders of MSCs in aging via modulating microenvironments, by using signaling modulators, anti-inflammatory agents, antioxidants, and metabolic regulators.
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Stem cells derived from “inflamed” and healthy periodontal ligament tissues and their sheet functionalities: a patient‐matched comparison
TL;DR: Comparing the properties of stem cells derived from "inflamed" and healthy periodontal ligament (PDL) tissues from patient-matched groups indicates that stem cellsderived from damaged teeth extracted due to periodontitis warrant further exploration.
References
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Journal ArticleDOI
Investigation of multipotent postnatal stem cells from human periodontal ligament
Byoung Moo Seo,Masako Miura,Stan Gronthos,P. M. Bartold,Sara Batouli,Jaime S. Brahim,M. F. Young,Pamela Gehron Robey,Cun-Yu Wang,Songtao Shi +9 more
TL;DR: It is suggested that PDL contains stem cells that have the potential to generate cementum/PDL-like tissue in vivo and transplantation of these cells might hold promise as a therapeutic approach for reconstruction of tissues destroyed by periodontal diseases.
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Perceptions of epigenetics
TL;DR: During the past year, more than 2,500 articles, numerous scientific meetings and a new journal were devoted to the subject of epigenetics, portrayed by the popular press as a revolutionary new science — an antidote to the idea that the authors are hard-wired by their genes.
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GSK-3: tricks of the trade for a multi-tasking kinase.
TL;DR: Since increased GSK-3 activity may be linked to pathology in diseases such as Alzheimer's disease and non-insulin-dependent diabetes mellitus, several new G SKS-3 inhibitors, such as the aloisines, the paullones and the maleimides, have been developed and hold promise as therapeutic agents.
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Mesenchymal Stem Cells Derived from Dental Tissues vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine
TL;DR: This article will review the isolation and characterization of the properties of different dental MSC-like populations in comparison with those of other MSCs, such as BMMSCs.
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Phenotypic plasticity and the epigenetics of human disease
TL;DR: This model proposes that hereditary disorders of the epigenetic apparatus lead to developmental defects, that cancer epigenetics involves disruption of the stem-cell programme, and that common diseases with late-onset phenotypes involve interactions between the epigenome, the genome and the environment.