Journal ArticleDOI
Hantaviruses: Immunology, Treatment, and Prevention
Reads0
Chats0
TLDR
This review summarizes the current knowledge on hantaviral host immune responses, immune abnormalities, laboratory diagnosis, and antiviral therapy as well as the current approaches in vaccine development.Abstract:
Hantaviruses are rodent-borne bunyaviruses that are associated with two main clinical diseases in humans: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. It has been suggested that host-related immune mechanisms rather than direct viral cytopathology may be responsible for the principal abnormality (vascular dysfunction) in these syndromes. This review summarizes the current knowledge on hantaviral host immune responses, immune abnormalities, laboratory diagnosis, and antiviral therapy as well as the current approaches in vaccine development.read more
Citations
More filters
Journal ArticleDOI
Rodent-borne diseases and their risks for public health
TL;DR: A large number of pathogens that are directly or indirectly transmitted by rodents are described and a simplified rodent disease model is discussed.
Journal ArticleDOI
Relating increasing hantavirus incidences to the changing climate: the mast connection
Jan Clement,Jurgen Vercauteren,Willem W. Verstraeten,Geneviève Ducoffre,Jose Miguel Barrios,Anne-Mieke Vandamme,Piet Maes,Marc Van Ranst +7 more
TL;DR: NE peaks in year 0 are induced by abundant mast formation in year-1, facilitating bank vole survival during winter, thus putting the local human population at risk from the spring onwards of year 0, predicting that with the anticipated climate changes due to global warming, NE might become a highly endemic disease in Belgium and surrounding countries.
Journal ArticleDOI
Hantavirus in African wood mouse, Guinea.
Boris Klempa,Elisabeth Fichet-Calvet,Emilie Lecompte,Brita Auste,Vladimir M. Aniskin,Helga Meisel,Christiane Denys,Lamine Koivogui,Jan ter Meulen,Detlev H. Krüger +9 more
TL;DR: Sequence and phylogenetic analyses of the genetic material demonstrate a novel hantavirus species, which the authors propose to name "Sangassou virus".
Journal ArticleDOI
The changing epidemiology of acute renal failure
TL;DR: The absolute incidence of ARF has increased, while associated mortality rate has remained relatively static, and several factors have contributed to this altered epidemiology, which include site of disease onset, patient age, infections, and interventions.
Journal ArticleDOI
Viral hemorrhagic fevers
TL;DR: A taxonomically diverse set of single-stranded ribonucleic acid(ssRNA) viruses from four diverse viral families cause an acute systemic febrile syndrome called viral hemorrhagic fever (VHF).
References
More filters
Journal ArticleDOI
Changes in populations of immune effector cells during the course of haemorrhagic fever with renal syndrome
Richard M. Lewis,Ho Wang Lee,Anthony F. See,David B. Parrish,Jung Sik Moon,Dai Jung Kim,Thomas M. Cosgriff +6 more
TL;DR: To characterize the immune response in haemorrhagic fever with renal syndrome, serial changes in immune effector cells were measured in 14 patients and found initial elevations of all major leucocyte populations, increases in suppressor T cells and B cells, decreases in helper/suppressor cell ratios, and a dramatic increase in activated T cells.
Journal ArticleDOI
Epidemiology and laboratory diagnosis of Hantavirus (HTV) infections.
Jan Clement,P. McKenna,Jan Groen,Albert D. M. E. Osterhaus,P. Colson,T. Vervoort,Guido van der Groen,Ho Wang Lee +7 more
TL;DR: Serologic tests for detection of specific viral antibodies, Polymerase chain reaction for viral RNA genome typing and immunohistochemical colouring of the viral antigen in tissues seem to offer promising alternatives for the immediate future.
Journal ArticleDOI
Antiviral activities of tragacanthin polysaccharides on Punta Toro virus infections in mice.
Donald F. Smee,Robert W. Sidwell,John H. Huffman,John W. Huggins,Meir Kende,Anthony J. Verbiscar +5 more
TL;DR: Tragacanthin polysaccharides from Astragalus brachycentrus and AStragalus echidnaeformis plants, which are devoid of in vitro antiviral activity, were evaluated in a mouse model of Punta Toro virus (PTV) infection, providing evidence that activation of peritoneal macrophages by the poly Saccharides affords protection to infected animals.
Journal ArticleDOI
Rapid field test for detection of hantavirus antibodies in rodents
Helena Sirola,Eva R. Kallio,Vesa Koistinen,Ilpo Kuronen,Åke Lundkvist,A. Vaheri,Olli Vapalahti,Heikki Henttonen,Ale Närvänen +8 more
TL;DR: A new serological immunochromatographic rapid test was developed that detects anti-PUUV IgG antibodies in rodents and provides an applicable tool for studying PUUV and related hantavirus infections in arvicoline rodents.
Journal ArticleDOI
Detection of Puumala Hantavirus Antibody with ELISA Using a Recombinant Truncated Nucleocapsid Protein Expressed in Escherichia coli
TL;DR: The ELISA based on rNp118 represents an alternative and valid test for detection of antibodies to PUUV in human sera and an excellent correlation between the assays was found.