Journal ArticleDOI
Hantaviruses: Immunology, Treatment, and Prevention
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TLDR
This review summarizes the current knowledge on hantaviral host immune responses, immune abnormalities, laboratory diagnosis, and antiviral therapy as well as the current approaches in vaccine development.Abstract:
Hantaviruses are rodent-borne bunyaviruses that are associated with two main clinical diseases in humans: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. It has been suggested that host-related immune mechanisms rather than direct viral cytopathology may be responsible for the principal abnormality (vascular dysfunction) in these syndromes. This review summarizes the current knowledge on hantaviral host immune responses, immune abnormalities, laboratory diagnosis, and antiviral therapy as well as the current approaches in vaccine development.read more
Citations
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Rodent-borne diseases and their risks for public health
TL;DR: A large number of pathogens that are directly or indirectly transmitted by rodents are described and a simplified rodent disease model is discussed.
Journal ArticleDOI
Relating increasing hantavirus incidences to the changing climate: the mast connection
Jan Clement,Jurgen Vercauteren,Willem W. Verstraeten,Geneviève Ducoffre,Jose Miguel Barrios,Anne-Mieke Vandamme,Piet Maes,Marc Van Ranst +7 more
TL;DR: NE peaks in year 0 are induced by abundant mast formation in year-1, facilitating bank vole survival during winter, thus putting the local human population at risk from the spring onwards of year 0, predicting that with the anticipated climate changes due to global warming, NE might become a highly endemic disease in Belgium and surrounding countries.
Journal ArticleDOI
Hantavirus in African wood mouse, Guinea.
Boris Klempa,Elisabeth Fichet-Calvet,Emilie Lecompte,Brita Auste,Vladimir M. Aniskin,Helga Meisel,Christiane Denys,Lamine Koivogui,Jan ter Meulen,Detlev H. Krüger +9 more
TL;DR: Sequence and phylogenetic analyses of the genetic material demonstrate a novel hantavirus species, which the authors propose to name "Sangassou virus".
Journal ArticleDOI
The changing epidemiology of acute renal failure
TL;DR: The absolute incidence of ARF has increased, while associated mortality rate has remained relatively static, and several factors have contributed to this altered epidemiology, which include site of disease onset, patient age, infections, and interventions.
Journal ArticleDOI
Viral hemorrhagic fevers
TL;DR: A taxonomically diverse set of single-stranded ribonucleic acid(ssRNA) viruses from four diverse viral families cause an acute systemic febrile syndrome called viral hemorrhagic fever (VHF).
References
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Journal Article
New insights into the molecular mechanisms of its multiple actions
Jan Vilcek,T. H. Lee +1 more
Journal Article
Hantavirus Pulmonary Syndrome: Pathogenesis of an Emerging Infectious Disease
Sherif R. Zaki,Patricia W. Greer,L M Coffield,Cynthia S. Goldsmith,Kurt B. Nolte,Kathy Foucar,Richard M. Feddersen,Ross E. Zumwalt,Gayle L. Miller,Ali S. Khan,Pierre E. Rollin,Thomas G. Ksiazek,Stuart T. Nichol,Brian W. J. Mahy,Clarence J. Peters +14 more
TL;DR: Pulmonary histopathological features were similar in most of the fatal HPS cases and consisted of an interstitial pneumonitis with a variable mononuclear cell infiltrate, edema, and focal hyaline membranes, however, pulmonary features were significantly different and included diffuse alveolar damage and variable degrees of severe air space disorganization.
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β3 integrins mediate the cellular entry of hantaviruses that cause respiratory failure
TL;DR: It is reported that specific integrins expressed on platelets and endothelial cells permit the cellular entry of HPS-associated hantaviruses and indicates that hantvirus pathogenicity correlates with integrin usage.
Journal ArticleDOI
Hantaviruses: genome structure, expression and evolution.
TL;DR: The identification in 1993 of Sin Nombre virus (SN) as the causative agent of hantavirus-associated pulmonary syndrome (HPS) led to intensive search for further hantviruses and as a result today a total of as many as 16 well-established sero/genotypes may be listed.