Journal ArticleDOI
Hantaviruses: Immunology, Treatment, and Prevention
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TLDR
This review summarizes the current knowledge on hantaviral host immune responses, immune abnormalities, laboratory diagnosis, and antiviral therapy as well as the current approaches in vaccine development.Abstract:
Hantaviruses are rodent-borne bunyaviruses that are associated with two main clinical diseases in humans: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. It has been suggested that host-related immune mechanisms rather than direct viral cytopathology may be responsible for the principal abnormality (vascular dysfunction) in these syndromes. This review summarizes the current knowledge on hantaviral host immune responses, immune abnormalities, laboratory diagnosis, and antiviral therapy as well as the current approaches in vaccine development.read more
Citations
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Hantavirusinduzierte Nephropathia epidemica
TL;DR: Hantavirus-induced nephropathia epidemica is a relatively mild manifestation of hemorrhagic fever with renal syndrome which has a favorable prognosis and may require a differential diagnosis by renal biopsy.
Detection of Hantavirus Using a New Miniaturized Biosensor Device
TL;DR: A new smaller, automated electrochemi- cal immunosensor device for fastdetection of specific anti-hantavirus antibodies in mice blood has been made and a sandwich scheme immunoassay was used.
Journal ArticleDOI
Introduction of Vaccinomics to Develop Personalized Vaccines in Light of Changes in the Usage of Hantaan Virus Vaccine (Hantavax ® ) in Korea
TL;DR: The possibility of applying the innovative field of vaccinomics to develop a more effective and safer HTNV vaccine should be considered.
Journal ArticleDOI
Complete Genome Sequence of Nova Virus, a Hantavirus Circulating in the European Mole in Belgium.
Lies Laenen,Valentijn Vergote,Inne Nauwelaers,Ina Verbeeck,Liana E. Kafetzopoulou,Marc Van Ranst,Piet Maes +6 more
TL;DR: The complete genome sequence of Nova virus, a divergent hantavirus, originating from the kidney tissue of a European mole (Talpa europaea) from Belgium was determined.
Posted ContentDOI
Molecular rationale for hantavirus neutralization by a reservoir host-derived monoclonal antibody
Ilona Rissanen,Robert Stass,Stefanie A. Krumm,Jeffrey Seow,Ruben J.G. Hulswit,Guido C. Paesen,Jussi Hepojoki,Olli Vapalahti,Åke Lundkvist,Olivier Reynard,Viktor E. Volchkov,Katie J. Doores,Juha T. Huiskonen,Thomas A. Bowden +13 more
TL;DR: Cryo-electron microscopy of PUUV-like particles treated with Fab 4G2 demonstrates that the antibody binds to monomeric Gc at breaks in the Gn-Gc lattice, highlighting the immunological accessibility of Gc monomers on the mature hantavirus surface and the plastic nature of the higher-order lattice assembly.
References
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Journal ArticleDOI
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Kevin J. Tracey,Kevin J. Tracey,Yuman Fong,David G. Hesse,Kirk R. Manogue,Annette T. Lee,George C. Kuo,Stephen F. Lowry,Anthony Cerami +8 more
TL;DR: Protection against shock, vital organ dysfunction, persistent stress hormone release and death was conferred by administration of antibodies 2 h before bacterial infusion, indicating that cachectin is a mediator of fatal bacteraemic shock and suggesting that antibodies against Cachectin offer a potential therapy of life-threatening infection.
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The platelet membrane glycoprotein IIb-IIIa complex
TL;DR: The author’s website is www.hematologylibrary.org, which can be found online at http://bloodjournal.org/site/misc/rights.xhtml.
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Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness
Stuart T. Nichol,Christina F. Spiropoulou,Sergey P. Morzunov,Pierre E. Rollin,Thomas G. Ksiazek,Heinz Feldmann,Anthony Sanchez,James E. Childs,Sherif R. Zaki,Clarence J. Peters +9 more
TL;DR: A mysterious respiratory illness with high mortality was recently reported in the southwestern United States and nucleotide sequence analysis revealed the associated virus to be a new hantavirus and provided a direct genetic link between infection in patients and rodents.
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Isolation of the Etiologic Agent of Korean Hemorrhagic Fever
TL;DR: Diagnostic increases in immunofluorescent antibodies occurred in 113 of 116 severe and 11 of 34 milder cases of clinically suspected Korean hemorrhagic fever and Convalescent-phase sera from four persons suffering a similar disease in the Soviet Union were also positive for antibodies.