Journal ArticleDOI
Hantaviruses: Immunology, Treatment, and Prevention
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TLDR
This review summarizes the current knowledge on hantaviral host immune responses, immune abnormalities, laboratory diagnosis, and antiviral therapy as well as the current approaches in vaccine development.Abstract:
Hantaviruses are rodent-borne bunyaviruses that are associated with two main clinical diseases in humans: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. It has been suggested that host-related immune mechanisms rather than direct viral cytopathology may be responsible for the principal abnormality (vascular dysfunction) in these syndromes. This review summarizes the current knowledge on hantaviral host immune responses, immune abnormalities, laboratory diagnosis, and antiviral therapy as well as the current approaches in vaccine development.read more
Citations
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Journal ArticleDOI
Immunogenetic Factors Affecting Susceptibility of Humans and Rodents to Hantaviruses and the Clinical Course of Hantaviral Disease in Humans.
Nathalie Charbonnel,Marie Pagès,Marie Pagès,Tarja Sironen,Heikki Henttonen,Olli Vapalahti,Jukka Mustonen,Antti Vaheri +7 more
TL;DR: Results corroborated the hypothesis of an evolution of tolerance strategies in rodents and confirmed the associations of immunity-related genes with susceptibility of humans and rodents to hantaviruses, and with severity of hantviral diseases in humans.
Journal ArticleDOI
Sangassou Virus, the First Hantavirus Isolate from Africa, Displays Genetic and Functional Properties Distinct from Those of Other Murinae-Associated Hantaviruses
Boris Klempa,Boris Klempa,Peter T. Witkowski,Elena Popugaeva,Brita Auste,Lamine Koivogui,Elisabeth Fichet-Calvet,Thomas Strecker,Jan ter Meulen,Detlev H. Krüger +9 more
TL;DR: The characterization of the genetic and functional properties of the Sangassou virus showed that it uses β1 integrin rather than β3 integrin and decay-accelerating factor (DAF)/CD55 as an entry receptor, and a strong induction of type III lambda interferon expression in type I IFN-deficient Vero E6 cells by SANGV made it useful in comparative studies focusing on hantavirus pathogenesis.
Journal ArticleDOI
Synthesis of 1-β-d-ribofuranosyl-3-ethynyl-[1,2,4]triazole and its in vitro and in vivo efficacy against Hantavirus
Donghoon Chung,Sidath C. Kumarapperuma,Yanjie Sun,Qianjun Li,Yong Kyu Chu,Jeffrey B. Arterburn,William B. Parker,Jeffrey M. Smith,Kristin Spik,Harish N. Ramanathan,Connie S. Schmaljohn,Colleen B. Jonsson +11 more
TL;DR: ETAR is an exciting and promising lead compound that will be elaborated in further synthetic investigations as a framework for the rational design of new antivirals for treatment of HFRS.
Journal ArticleDOI
Inactivation of Hantaan virus-containing samples for subsequent investigations outside biosafety level 3 facilities.
TL;DR: The virus inactivation and depletion methods described herein are suitable to prepare non-infectious samples for further use in immunological, virological and cell-biological assays.
Journal ArticleDOI
Arenaviruses and hantaviruses: From epidemiology and genomics to antivirals
Rémi N. Charrel,Bruno Coutard,Cécile Baronti,Bruno Canard,Antoine Nougairède,Antoine Frangeul,Benjamin Morin,Saïd Jamal,Christian L. Schmidt,Rolf Hilgenfeld,Boris Klempa,Boris Klempa,X. de Lamballerie +12 more
TL;DR: Progress in understanding the genomics as well as the structure and function of replicative enzymes achieved under the VIZIER program is reviewed and the development of new disease control strategies are reviewed.
References
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Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness
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TL;DR: A mysterious respiratory illness with high mortality was recently reported in the southwestern United States and nucleotide sequence analysis revealed the associated virus to be a new hantavirus and provided a direct genetic link between infection in patients and rodents.
Journal ArticleDOI
Isolation of the Etiologic Agent of Korean Hemorrhagic Fever
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