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Helicobacter pylori infection and gastric cancer: host, bug, environment, or all three?
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TLDR
This review highlights recent advances in knowledge on H. pylori disease pathogenesis, focusing on the role of the host, bacteria, and environment in the development of gastric carcinoma.Abstract:
Helicobacter pylori is a common bacterial pathogen that colonizes the gastric mucosa of over 50% of the world’s population. All infected individuals exhibit chronic gastric inflammation, and approximately 1% of patients develop gastric cancers, including adenocarcinomas and mucosal-associated lymphoid tissue lymphomas. In 1994, the World Health Organization International Agency for Research on Cancer classified H. pylori as a type I, or definite carcinogen. Because the prevalence of gastric cancers among H. pyloriinfected patients varies between individuals, countries, and geographic areas, H. pylori disease-related outcomes are believed to be determined by an interplay between host factors, bacterial factors, and their interaction with the environment. This review highlights recent advances in our knowledge on H. pylori disease pathogenesis, focusing on the role of the host, bacteria, and environment in the development of gastric carcinoma.read more
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Bioinformatics and the Cell: Modern Computational Approaches in Genomics, Proteomics and Transcriptomics
TL;DR: This paper presents a meta-modelling framework that automates the very labor-intensive and therefore time-heavy and therefore expensive and expensive process of cell reprograming called “coding”.
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Presence of terminal N-acetylgalactosamineβ1-4N-acetylglucosamine residues on O-linked oligosaccharides from gastric MUC5AC: Involvement in Helicobacter pylori colonization?
Diarmuid T. Kenny,Diarmuid T. Kenny,Emma C. Skoog,Sara K. Lindén,Weston B. Struwe,Pauline M. Rudd,Niclas G. Karlsson +6 more
TL;DR: It is hypothesize that the termination on gastric MUC5AC with lacdiNAc is in competition with complex glycosylation such as the Le(b) and H type 1 as well as complex sialylated structures.
Journal ArticleDOI
Links between Propionibacterium acnes and prostate cancer
TL;DR: Several characteristics of prostate cancer suggest the involvement of an infectious agent and it is proposed that Propionibacterium acnes is an excellent candidate and cultured P. acnes from a substantial proportion of prostate glands containing cancer shown a significant positive association with prostatic inflammation.
Journal ArticleDOI
Expression and prognostic values of Id-1 and Id-3 in gastric adenocarcinoma.
Haiyan Yang,Hao-Ling Liu,Gai-Yun Liu,Hong Zhu,Qing-Wen Meng,Lian-Dong Qu,Lianxin Liu,Hongchi Jiang +7 more
TL;DR: In cancer samples, stronger Id-1 and -3 expression is associated with poor differentiation and more aggressive behavior of tumor cells, resulting in poor clinical outcome, Consequently, Id-3 might be used to independently predict survival of patients with gastric cancer.
Journal ArticleDOI
Detection and location of Helicobacter pylori in human gastric carcinomas
TL;DR: Results suggested that H pylori infection might play a certain role in the early stage of carcinogenesis of human gastric mucosa epithelia.
References
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TL;DR: This review considers current knowledge about the epidemiology and transmission of H. pylori, as well as the role of this infectious agent in the pathogenesis of upper gastrointestinal tract disease.
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NF-κB in cancer: from innocent bystander to major culprit
TL;DR: Recent evidence indicates that NF-κB and the signalling pathways that are involved in its activation are also important for tumour development.
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Interleukin-1 polymorphisms associated with increased risk of gastric cancer
Emad M. El-Omar,Emad M. El-Omar,Mary Carrington,Wong Ho Chow,Kenneth E.L. McColl,Jay H. Bream,Howard A. Young,Jesus Herrera,Jolanta Lissowska,Chiu Chin Yuan,Nathaniel Rothman,George Lanyon,Maureen P. Martin,Joseph F. Fraumeni,Charles S. Rabkin +14 more
TL;DR: It is reported that interleukin-1 gene cluster polymorphisms suspected of enhancing production of interleucine-1-beta are associated with an increased risk of both hypochlorhydria induced by H. pylori and gastric cancer.
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The STATs of cancer — new molecular targets come of age
Hua Yu,Richard Jove +1 more
TL;DR: Tumour cells acquire the ability to proliferate uncontrollably, resist apoptosis, sustain angiogenesis and evade immune surveillance, and STAT proteins — especially STAT3 and STAT5 — regulate all of these processes and are persistence activated in a surprisingly large number of human cancers.
Journal ArticleDOI
Helicobacter pylori and gastrointestinal tract adenocarcinomas
Richard M. Peek,Martin J. Blaser +1 more
TL;DR: Understanding the host–microbial interactions that lead to neoplasia will improve cancer-targeted therapeutics and diagnostics, and provide mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.