Journal ArticleDOI
Hepatic microcirculation and mechanisms of portal hypertension.
TLDR
The present Review describes the current knowledge of liver microcirculatory dysfunction in cirrhotic portal hypertension and appraise the preclinical models used to study the liver circulation and provides a comprehensive summary of the promising therapeutic options to target the liver microvasculature in Cirrhosis.Abstract:
The liver microcirculatory milieu, mainly composed of liver sinusoidal endothelial cells (LSECs), hepatic stellate cells (HSCs) and hepatic macrophages, has an essential role in liver homeostasis, including in preserving hepatocyte function, regulating the vascular tone and controlling inflammation. Liver microcirculatory dysfunction is one of the key mechanisms that promotes the progression of chronic liver disease (also termed cirrhosis) and the development of its major clinical complication, portal hypertension. In the present Review, we describe the current knowledge of liver microcirculatory dysfunction in cirrhotic portal hypertension and appraise the preclinical models used to study the liver circulation. We also provide a comprehensive summary of the promising therapeutic options to target the liver microvasculature in cirrhosis.read more
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Enoxaparin Prevents Portal Vein Thrombosisand Liver Decompensation in Patients With Advanced Cirrhosis.
Calogero Cammà,Salvatore Petta,Cristina Tata,Mariagrazia Del Buono,Filippo Schepis,Monica Luongo,Nicola De Maria,Marco Marietta,Giovanni Fornaciari,Barbara Lei,Dominique Valla,Dominique Valla,Stefano Colopi,Veronica Bernabucci,Ranka Vukotic,Stefano Gitto,Rosina Maria Critelli,Aimilia Karampatou,Elena Turola,Erica Villa,Luisa Simoni,Susanna Schianchi,Beatrice Zambotto,Ramona Zecchini,Cristian Caporali,Anna Ferrari +25 more
TL;DR: In a small randomized controlled trial, a 12-month course of enoxaparin was safe and effective in preventing PVT in patients with cirrhosis and a Child-Pugh score of 7-10 and to improve survival.
Journal ArticleDOI
Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease
TL;DR: Improving LSEC health appears to be a promising approach to prevent NAFLD progression and complications.
Journal ArticleDOI
Role of liver sinusoidal endothelial cells in liver diseases.
Jordi Gracia-Sancho,Jordi Gracia-Sancho,Esther Caparrós,Anabel Fernández-Iglesias,Rubén Francés +4 more
TL;DR: In this article, the main functions and phenotypic dysregulations of sinusoidal endothelial cells (LSECs) in liver diseases, specifically in the context of acute injury (ischaemia-reperfusion injury, drug-induced liver injury and bacterial and viral infection), chronic liver disease (metabolism-associated liver disease, alcoholic steatohepatitis and chronic hepatotoxic injury) and hepatocellular carcinoma, and provides a comprehensive update of the role of LSECs as therapeutic targets for liver disease.
Journal ArticleDOI
Pathophysiology of decompensated cirrhosis: Portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction.
TL;DR: In this article, a review amalgamates the latest knowledge on disease mechanisms that lead to tissue injury and extrahepatic organ failure - such as systemic inflammation, mitochondrial dysfunction, oxidative stress and metabolic changes - and marries these with the classical paradigms of acute decompensation to form a single paradigm.
Journal ArticleDOI
Pan-PPAR agonist lanifibranor improves portal hypertension and hepatic fibrosis in experimental advanced chronic liver disease.
Zoe Boyer-Diaz,Peio Aristu-Zabalza,María Andrés-Rozas,Claude Robert,Martí Ortega-Ribera,Anabel Fernández-Iglesias,Pierre Broqua,Jean-Louis Junien,Guillaume Wettstein,Jaime Bosch,Jordi Gracia-Sancho +10 more
TL;DR: This study demonstrates that lanifibranor exerts clear beneficial effects in pre-clinical models of decompensated cirrhosis, which lead to amelioration in fibrosis and portal hypertension.
References
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Journal ArticleDOI
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