Journal ArticleDOI
High-grade glioma radiation therapy target volumes and patterns of failure obtained from magnetic resonance imaging and 18F-FDOPA positron emission tomography delineations from multiple observers.
Robert Kosztyla,Elisa K. Chan,Fred Hsu,Don Wilson,Roy Ma,Arthur Cheung,Susan Zhang,Vitali Moiseenko,Francois Benard,Alan Nichol +9 more
TLDR
High-grade glioma contours obtained with (18)F-FDOPA PET had similar interobserver agreement to volumes obtained with MRI, and PET-based consensus target volumes were larger than MRI-based volumes.Abstract:
Purpose The objective of this study was to compare recurrent tumor locations after radiation therapy with pretreatment delineations of high-grade gliomas from magnetic resonance imaging (MRI) and 3,4-dihydroxy-6-[ 18 F]fluoro-l-phenylalanine ( 18 F-FDOPA) positron emission tomography (PET) using contours delineated by multiple observers. Methods and Materials Nineteen patients with newly diagnosed high-grade gliomas underwent computed tomography (CT), gadolinium contrast-enhanced MRI, and 18 F-FDOPA PET/CT. The image sets (CT, MRI, and PET/CT) were registered, and 5 observers contoured gross tumor volumes (GTVs) using MRI and PET. Consensus contours were obtained by simultaneous truth and performance level estimation (STAPLE). Interobserver variability was quantified by the percentage of volume overlap. Recurrent tumor locations after radiation therapy were contoured by each observer using CT or MRI. Consensus recurrence contours were obtained with STAPLE. Results The mean interobserver volume overlap for PET GTVs (42% ± 22%) and MRI GTVs (41% ± 22%) was not significantly different ( P =.67). The mean consensus volume was significantly larger for PET GTVs (58.6 ± 52.4 cm 3 ) than for MRI GTVs (30.8 ± 26.0 cm 3 , P =.003). More than 95% of the consensus recurrence volume was within the 95% isodose surface for 11 of 12 (92%) cases with recurrent tumor imaging. Ten (91%) of these cases extended beyond the PET GTV, and 9 (82%) were contained within a 2-cm margin on the MRI GTV. One recurrence (8%) was located outside the 95% isodose surface. Conclusions High-grade glioma contours obtained with 18 F-FDOPA PET had similar interobserver agreement to volumes obtained with MRI. Although PET-based consensus target volumes were larger than MRI-based volumes, treatment planning using PET-based volumes may not have yielded better treatment outcomes, given that all but 1 recurrence extended beyond the PET GTV and most were contained by a 2-cm margin on the MRI GTV.read more
Citations
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Journal ArticleDOI
From the clinician's point of view - What is the status quo of positron emission tomography in patients with brain tumors?
TL;DR: In the last decade, PET studies using radiolabeled amino acids appear to improve clinical decision-making as these tracers can offer better delineation of tumor extent as well as improved targeting of biopsies, surgical interventions, and radiation therapy.
Journal ArticleDOI
Brain Tumors: An Update on Clinical PET Research in Gliomas.
TL;DR: This review provides an update on clinical PET studies, most of which are motivated by prediction of prognosis and planning and monitoring of therapy in gliomas, and investigates the combination of PET with advanced multimodal MR imaging methods.
Journal ArticleDOI
Contribution of PET imaging to radiotherapy planning and monitoring in glioma patients - a report of the PET/RANO group
Norbert Galldiks,Norbert Galldiks,Maximilian Niyazi,Anca L. Grosu,Martin Kocher,Martin Kocher,Karl-Josef Langen,Karl-Josef Langen,Ian Law,Giuseppe Minniti,Michelle M. Kim,Christina Tsien,Frédéric Dhermain,Riccardo Soffietti,Minesh P. Mehta,Minesh P. Mehta,Michael Weller,Jörg C. Tonn +17 more
TL;DR: A summary of the literature and recommendations for the use of PET imaging for radiotherapy of patients with glioma based on published studies, constituting levels 1-3 evidence according to the Oxford Centre for Evidence-based Medicine as mentioned in this paper.
Book
Diffuse Low-Grade Gliomas in Adults
TL;DR: A better knowledge of the brain connectome and neuroplasticity enables us to take into consideration interactions between the disease and the host, and thus to elaborate dynamic and multimodal therapeutic strategies with the goal to increase the median survival as well as to improve the quality of life.
Journal ArticleDOI
Increasing feasibility and utility of 18 F-FDOPA PET for the management of glioma
Christopher Bell,Nicholas Dowson,Simon Puttick,Yaniv Gal,Paul Thomas,Michael Fay,Jye Smith,Stephen E. Rose +7 more
TL;DR: F-FDOPA PET appears to be a viable radiopharmaceutical for the diagnosis and treatment planning of gliomas cases, improving on that of MRI and (18)F- FDG PET.
References
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Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
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