High numerical aperture tabletop soft x-ray diffraction microscopy with 70-nm resolution
Richard L. Sandberg,Changyong Song,Przemyslaw Wachulak,Daisy Raymondson,Ariel Paul,Bagrat Amirbekian,Edwin A. Lee,Anne Sakdinawat,Chan La-o-vorakiat,Mario C. Marconi,Carmen S. Menoni,Margaret M. Murnane,Jorge J. Rocca,Henry C. Kapteyn,Jianwei Miao +14 more
TLDR
A versatile soft x-ray diffraction microscope with 70- to 90-nm resolution with high numerical aperture imaging and near-diffraction-limited resolution is reported by using two different tabletop coherent softx-ray sources—a soft x -ray laser and a high-harmonic source.Abstract:
Light microscopy has greatly advanced our understanding of nature. The achievable resolution, however, is limited by optical wavelengths to ≈200 nm. By using imaging and labeling technologies, resolutions beyond the diffraction limit can be achieved for specialized specimens with techniques such as near-field scanning optical microscopy, stimulated emission depletion microscopy, and photoactivated localization microscopy. Here, we report a versatile soft x-ray diffraction microscope with 70- to 90-nm resolution by using two different tabletop coherent soft x-ray sources—a soft x-ray laser and a high-harmonic source. We also use field curvature correction that allows high numerical aperture imaging and near-diffraction-limited resolution of 1.5λ. A tabletop soft x-ray diffraction microscope should find broad applications in biology, nanoscience, and materials science because of its simple optical design, high resolution, large depth of field, 3D imaging capability, scalability to shorter wavelengths, and ultrafast temporal resolution.read more
Citations
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Phase Retrieval with Application to Optical Imaging: A contemporary overview
TL;DR: The goal is to describe the current state of the art in this area, identify challenges, and suggest future directions and areas where signal processing methods can have a large impact on optical imaging and on the world of imaging at large.
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The attosecond nonlinear optics of bright coherent X-ray generation
TL;DR: In this paper, the Roentgen X-ray tube was used for high-order harmonic generation with small-scale femtosecond laser technology, which combines the microscopic attosecond science of atoms driven by intense laser fields with the macroscopic extreme nonlinear optics of phase matching.
Journal ArticleDOI
Coherent methods in the X-ray sciences
TL;DR: A review of the areas in which ideas from coherent X-ray methods are contributing to methods for the neutron, electron and optical communities is presented in this article, along with associated experiments in materials science.
Journal ArticleDOI
Phase matching of high harmonic generation in the soft and hard X-ray regions of the spectrum
Tenio Popmintchev,Ming-Chang Chen,Alon Bahabad,Michael Gerrity,Pavel Sidorenko,Oren Cohen,Ivan P. Christov,Margaret M. Murnane,Henry C. Kapteyn +8 more
TL;DR: The rapidly decreasing microscopic single-atom yield, predicted for harmonics driven by longer-wavelength lasers, is compensated macroscopically by an increased optimal pressure for phase matching and a rapidly decreasing reabsorption of the generated X-rays, making tabletop, fully coherent, multi-keV X-ray sources feasible.
Journal ArticleDOI
Quantitative 3D imaging of whole, unstained cells by using X-ray diffraction microscopy.
Huaidong Jiang,Changyong Song,Chien-Chun Chen,Rui Xu,Kevin S. Raines,Benjamin P. Fahimian,Chien-Hung Lu,Ting-Kuo Lee,Akio Nakashima,Jun Urano,Tetsuya Ishikawa,Fuyuhiko Tamanoi,Jianwei Miao +12 more
TL;DR: This work identified the 3D morphology and structure of cellular organelles including cell wall, vacuole, endoplasmic reticulum, mitochondria, granules, nucleus, and nucleolus inside a yeastSpore cell and observed a 3D structure protruding from the reconstructed yeast spore, suggesting the spore germination process.
References
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Extending the methodology of X-ray crystallography to allow imaging of micrometre-sized non-crystalline specimens
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Femtosecond diffractive imaging with a soft-X-ray free-electron laser
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TL;DR: In this paper, the FLASH soft X-ray free-electron laser was used to reconstruct a coherent diffraction pattern from a nano-structured nonperiodic object, before destroying it at 60,000 K.
Journal ArticleDOI
Phase-Matched Generation of Coherent Soft X-rays
A. Rundquist,Charles G. Durfee,Zenghu Chang,Catherine M. Herne,Sterling Backus,Margaret M. Murnane,Henry C. Kapteyn +6 more
TL;DR: Phase-matched harmonic conversion of visible laser light into soft x-rays was demonstrated and the recently developed technique of guided-wave frequency conversion was used to upshift light from 800 nanometers to the range from 17 to 32 nanometers.
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Three-dimensional mapping of a deformation field inside a nanocrystal
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