Journal ArticleDOI
Histone acetylation in chromatin structure and transcription
TLDR
The amino termini of histones extend from the nucleosomal core and are modified by acetyltransferases and deacetylases during the cell cycle, which may direct histone assembly and help regulate the unfolding and activity of genes.Abstract:
'The amino termini of histones extend from the nucleosomal core and are modified by acetyltransferases and deacetylases during the cell cycle These acetylation patterns may direct histone assembly and help regulate the unfolding and activity of genesread more
Citations
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Journal ArticleDOI
The language of covalent histone modifications.
Brian D. Strahl,C D Allis +1 more
TL;DR: It is proposed that distinct histone modifications, on one or more tails, act sequentially or in combination to form a ‘histone code’ that is, read by other proteins to bring about distinct downstream events.
Journal ArticleDOI
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
Xinsheng Nan,Huck-Hui Ng,Colin A. Johnson,Carol D. Laherty,Bryan M. Turner,Robert N. Eisenman,Adrian Bird +6 more
TL;DR: The data suggest that two global mechanisms of gene regulation, DNA methylation and histone deacetylation, can be linked by MeCP2, an abundant nuclear protein that is essential for mouse embryogenesis.
Journal ArticleDOI
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Kendle M. Maslowski,Angélica T. Vieira,Angélica T. Vieira,Aylwin Ng,Jan Kranich,Frederic Sierro,Di Yu,Heidi C. Schilter,Heidi C. Schilter,Michael S. Rolph,Fabienne Mackay,Fabienne Mackay,David Artis,Ramnik J. Xavier,Ramnik J. Xavier,Mauro M. Teixeira,Charles R. Mackay +16 more
TL;DR: It is shown that SCFA–GPR43 interactions profoundly affect inflammatory responses, and GPR43 binding of SCFAs potentially provides a molecular link between diet, gastrointestinal bacterial metabolism, and immune and inflammatory responses.
Journal ArticleDOI
Colonic health: fermentation and short chain fatty acids.
TL;DR: More human studies are now needed on SCFAs, especially, given the diverse nature of carbohydrate substrates and the SCFA patterns resulting from their fermentation, which will be key to the success of dietary recommendations to maximize colonic disease prevention.
Journal ArticleDOI
The many roles of histone deacetylases in development and physiology: Implications for disease and therapy
TL;DR: In this article, the expression of many HDAC isoforms in eukaryotic cells raises questions about their possible specificity or redundancy, and whether they control global or specific programs of gene expression.
References
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Journal ArticleDOI
The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
TL;DR: It is demonstrated that p300/CBP acetylates nucleosomes in concert with PCAF, a novel class of acetyltransferases in that it does not have the conserved motif found among various other acetyl transferases.
Journal ArticleDOI
The CBP co-activator is a histone acetyltransferase
TL;DR: It is shown that CBP has intrinsic HAT activity, and Targeting CBP-associated H AT activity to specific promoters may be a mechanism by which E1A acts as a transcriptional activator.
Journal ArticleDOI
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.
TL;DR: A role for histone deacetylase as a key regulator of eukaryotic transcription is supported by the predicted protein, which is very similar to the yeast transcriptional regulator Rpd3p.
Journal ArticleDOI
Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation
J. E. Brownell,J. Zhou,Tamara A. Ranalli,R. Kobayashi,Diane G. Edmondson,S. Y. Roth,C. D. Allis +6 more
TL;DR: These findings shed light on the biochemical function of the evolutionarily conserved Gcn5p-Ada complex, directly linking histone acetylation to gene activation, and indicate that histoneacetylation is a targeted phenomenon.
Journal ArticleDOI
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
Xiang Jiao Yang,Vasily Ogryzko,Jun-ichi Nishikawa,Jun-ichi Nishikawa,Bruce H. Howard,Yoshihiro Nakatani +5 more
TL;DR: A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A, a new adenoviral oncoprotein that induces progression through the cell cycle by binding to the products of the p300 and retinoblastoma gene families.