HO-1 expression increases mesenchymal stem cell-derived osteoblasts but decreases adipocyte lineage.
Luca Vanella,Dong Hyun Kim,David Asprinio,Stephen J. Peterson,Ignazio Barbagallo,Angelo Vanella,Dove Goldstein,Susumu Ikehara,Attallah Kappas,Nader G. Abraham,Nader G. Abraham +10 more
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Targeting HO-1 expression is a portal to increased osteoblast stem cell differentiation and to the attenuation of osteoporosis by the promotion of bone formation.About:Â
This article is published in Bone.The article was published on 2010-01-01 and is currently open access. It has received 116 citations till now. The article focuses on the topics: Cellular differentiation & Adipogenesis.read more
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Heme oxygenase-1 in tumor biology and therapy.
TL;DR: The implications of HO-1 properties for tumor proliferation and cell death, differentiation, angiogenesis and metastasis, and tumor-related inflammation are discussed and it is suggested that pharmacological agents that regulate HO activity orHO-1 gene silencing may become powerful tools for preventing the onset or progression of various cancers and sensitize them to anticancer therapies.
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Haem oxygenase-1: non-canonical roles in physiology and pathology.
TL;DR: Recent results indicate that HO-1 may also act through the regulation of microRNAs, which suggests a much broader involvement of HO- 1 in the modulation of cell functions and offers a potential explanation for some well-known activities whose mechanism has hitherto been unclear.
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Type 2 diabetes mellitus and fracture risk.
TL;DR: Optimal strategies to reduce skeletal fragility in type 2 diabetic patients are yet to be determined, although more data are needed.
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Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome
TL;DR: This review reflects the dramatic increase in research on the role of increased expression of heme oxygenase (HO)-1/HO-2, biliverdin reductase, and HO activity on vascular disease.
References
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Journal ArticleDOI
Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
Journal ArticleDOI
A simple, rapid, and sensitive DNA assay procedure.
C Labarca,Kenneth Paigen +1 more
TL;DR: The dissociation of chromatin is critical to accurate determinations of DNA in biological materials using this method, which can detect as little as 10 ng of DNA with rather unsophisticated instrumentation.
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Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors
Giuliana Ferrari,Gabriella Cusella,Gabriella Cusella,D. De Angelis,D. De Angelis,M. Coletta,M. Coletta,Egle Paolucci,Egle Paolucci,Anna Stornaiuolo,Anna Stornaiuolo,Giulio Cossu,Giulio Cossu,Fulvio Mavilio,Fulvio Mavilio +14 more
TL;DR: Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers.
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Stimulation of bone formation in vitro and in rodents by statins.
Gregory R. Mundy,R I Garrett,Stephen E. Harris,J. Chan,David J. Chen,G. Rossini,Brendan F. Boyce,Ming Zhao,Gloria Gutierrez +8 more
TL;DR: It is shown that the statins, drugs widely used for lowering serum cholesterol, also enhance new bone formation in vitro and in rodents, and may have therapeutic applications for the treatment of osteoporosis.
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Pharmacological and Clinical Aspects of Heme Oxygenase
Nader G. Abraham,Attallah Kappas +1 more
TL;DR: The use of pharmacological and genetic probes to manipulate HO, leading to new insights into the complex relationship of the HO system with biological and pathological phenomena under investigation, is reviewed.