Journal ArticleDOI
Pharmacological and Clinical Aspects of Heme Oxygenase
Nader G. Abraham,Attallah Kappas +1 more
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TLDR
The use of pharmacological and genetic probes to manipulate HO, leading to new insights into the complex relationship of the HO system with biological and pathological phenomena under investigation, is reviewed.Abstract:
This review is intended to stimulate interest in the effect of increased expression of heme oxygenase-1 (HO-1) protein and increased levels of HO activity on normal and pathological states. The HO system includes the heme catabolic pathway, comprising HO and biliverdin reductase, and the products of heme degradation, carbon monoxide (CO), iron, and biliverdin/bilirubin. The role of the HO system in diabetes, inflammation, heart disease, hypertension, neurological disorders, transplantation, endotoxemia and other pathologies is a burgeoning area of research. This review focuses on the clinical potential of increased levels of HO-1 protein and HO activity to ameliorate tissue injury. The use of pharmacological and genetic probes to manipulate HO, leading to new insights into the complex relationship of the HO system with biological and pathological phenomena under investigation, is reviewed. This information is critical in both drug development and the implementation of clinical approaches to moderate and to alleviate the numerous chronic disorders in humans affected by perturbations in the HO system.read more
Citations
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Journal ArticleDOI
The therapeutic potential of carbon monoxide.
TL;DR: An overview of the physiology of CO is provided, the effects of CO gas and CO-releasing molecules in preclinical animal models of cardiovascular disease, inflammatory disorders and organ transplantation are summarized, and the development and therapeutic options for the exploitation of this simple gaseous molecule are discussed.
Journal ArticleDOI
Mechanisms of Cell Protection by Heme Oxygenase-1
TL;DR: The mechanism underlying this cytoprotective effect relies on the ability of HO-1 to catabolize free heme and prevent it from sensitizing cells to undergo programmed cell death.
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Mammalian expression of infrared fluorescent proteins engineered from a bacterial phytochrome.
Xiaokun Shu,Antoine Royant,Michael Z. Lin,Todd A. Aguilera,Varda Lev-Ram,Paul Steinbach,Roger Y. Tsien +6 more
TL;DR: It is shown that a bacteriophytochrome from Deinococcus radiodurans can be engineered into monomeric, infrared-fluorescent proteins (IFPs), with excitation and emission maxima of 684 and 708 nm, respectively; extinction coefficient >90,000 M−1 cm−1; and quantum yield of 0.07.
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Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities
William I. Sivitz,Mark A. Yorek +1 more
TL;DR: This review considers different forms of diabetes and addresses the role of mitochondrial uncoupling and coenzyme Q, and the potential for targeting mitochondria in the therapy of diabetes.
Journal ArticleDOI
Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease.
TL;DR: Given the role of impaired Nrf2 activity in CKD-induced oxidative stress and inflammation, interventions aimed at restoring Nrf1 may be effective in retarding CKD progression and the potential utility of targeting NRF2 in the treatment of CKD is provided.
References
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Oxygen toxicity, oxygen radicals, transition metals and disease
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Induction of apoptotic program in cell-free extracts : requirement for datp and cytochrome c
TL;DR: Cells undergoing apoptosis in vivo showed increased release of cy tochrome c to their cytosol, suggesting that mitochondria may function in apoptosis by releasing cytochrome c.
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Increased oxidative stress in obesity and its impact on metabolic syndrome
Shigetada Furukawa,Takuya Fujita,Michio Shimabukuro,Masanori Iwaki,Yukio Yamada,Yoshimitsu Nakajima,Osamu Nakayama,Makoto Makishima,Morihiro Matsuda,Iichiro Shimomura +9 more
TL;DR: It is suggested that increased oxidative stress in accumulated fat is an early instigator of metabolic syndrome and that the redox state in adipose tissue is a potentially useful therapeutic target for obesity-associated metabolic syndrome.
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Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease
TL;DR: In summary, insulin resistance appears to be a syndrome that is associated with a clustering of metabolic disorders, including non-insulin-dependent diabetes mellitus, obesity, hypertension, lipid abnormalities, and atherosclerotic cardiovascular disease.
Journal ArticleDOI
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