Human Intestinal H+/Peptide Cotransporter: CLONING, FUNCTIONAL EXPRESSION, AND CHROMOSOMAL LOCALIZATION
Rong Liang,You-Jun Fei,Puttur D. Prasad,Sammanda Ramamoorthy,Hong Han,Teresa L. Yang-Feng,Matthias A. Hediger,Vadivel Ganapathy,Frederick H. Leibach +8 more
TLDR
Ch Chromosomal assignment studies with somatic cell hybrid analysis and in situ hybridization have located the gene encoding the cloned human H+/peptide cotransporter to chromosome 13 q33→q34.About:
This article is published in Journal of Biological Chemistry.The article was published on 1995-03-24 and is currently open access. It has received 505 citations till now. The article focuses on the topics: Peptide transport & Peptide transporter 1.read more
Citations
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Journal ArticleDOI
Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation
TL;DR: A comprehensive overview of transporters of the solute carrier family (SLC) is provided with regard to tissue distribution, subcellular localization, and substrate preferences.
Journal ArticleDOI
Molecular and integrative physiology of intestinal peptide transport.
TL;DR: Transcriptional and post-transcriptional regulation of PEPT1 occurs in response to alterations in the nutritional status and in disease states, suggesting a prime role of this transporter in amino acid absorption.
Journal ArticleDOI
Targeted prodrug design to optimize drug delivery
Hyo Kyung Han,Gordon L. Amidon +1 more
TL;DR: This review highlights evolving strategies in targeted prodrug design, including antibody-directed enzyme prodrug therapy, genedirected enzyme pro drug therapy, and peptide transporter-associated prodrug Therapy.
Journal ArticleDOI
The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology
Hannelore Daniel,Gabor Kottra +1 more
TL;DR: Mammalian members of the SLC15 family are electrogenic transporters that utilize the proton-motive force for uphill transport of short chain peptides and peptido-mimetics into a variety of cells.
Journal ArticleDOI
Cellular and molecular aspects of drug transport in the kidney
TL;DR: Detailed information concerning molecular and cellular aspects of drug transporters expressed in the kidney has facilitated studies of the mechanisms underlying renal disposition as well as transporter-mediated drug interactions.
References
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DNA sequencing with chain-terminating inhibitors
TL;DR: A new method for determining nucleotide sequences in DNA is described, which makes use of the 2',3'-dideoxy and arabinon nucleoside analogues of the normal deoxynucleoside triphosphates, which act as specific chain-terminating inhibitors of DNA polymerase.
Journal ArticleDOI
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.
TL;DR: By analyzing the effects of single base substitutions around the ATG initiator codon in a cloned preproinsulin gene, ACCATGG is identified as the optimal sequence for initiation by eukaryotic ribosomes.
Book
Physiology of the Gastrointestinal Tract
TL;DR: Physiology of the Gastrointestinal Tract, Fifth Edition - winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine - covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine.
Journal ArticleDOI
Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.
Sammanda Ramamoorthy,Andrea L. Bauman,Kim R. Moore,Hong Han,Teresa L. Yang-Feng,Albert S. Chang,Vadivel Ganapathy,Randy D. Blakely +7 more
TL;DR: A Na(+)- and Cl(-)-coupled serotonin (5-hydroxytryptamine, 5HT) transporter is expressed on human neuronal, platelet, placental, and pulmonary membranes and sequence analysis reveals a 630-amino acid open reading frame bearing 92% identity to the cloned rat brain 5HT transporter.
Journal ArticleDOI
Expression cloning of a mammalian proton-coupled oligopeptide transporter
You Jun Fei,You Jun Fei,Yoshikatsu Kanai,Yoshikatsu Kanai,Stephan Nussberger,Vadivel Ganapathy,Frederick H. Leibach,Michael F. Romero,Satish K. Singh,Walter F. Boron,Matthias A. Hediger +10 more
TL;DR: The cloning and functional characterization of a H+-coupled transporter of oligopeptides and peptide-derived antibiotics from rabbit small intestine is reported, and the PepT1 primary structure is the first reported for a proton-Coupled organic solute transporter in vertebrates.