Human Respiratory Coronaviruses Detected In Patients with Influenza-Like Illness in Arkansas, USA
Camila S. Silva,Lisa B. Mullis,Olavo S. Pereira,Linda J. Saif,Anastasia N. Vlasova,Xuming Zhang,Randall J Owens,Dale Paulson,Deborah R. Taylor,Lia M. Haynes,Marli P Azevedo +10 more
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TLDR
HCoV was the sole respiratory virus detected in 16% of the patients who showed acute respiratory symptoms with negative diagnoses for influenza virus, and HCoV-OC43, NL63, HKU1 and new feline-like strains were circulating in Arkansas in 2010.Citations
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Human Coronavirus-HKU1 Infection Among Adults in Cleveland, Ohio.
TL;DR: Coronavirus-HKU1 accounted for 1.6% of adult respiratory infections and should be considered in differential diagnosis of severe respiratory illnesses among adults.
Novel Canine Coronavirus Isolated from a Hospitalized Patient With Pneumonia in East Malaysia
TL;DR: This is the first report of a novel canine-feline recombinant alphacoronavirus isolated from a human patient with pneumonia, and may represent the eighth unique coronavirus known to cause disease in humans.
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Species-specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults.
Monique Bouvier,Wei-Ju Chen,Wei-Ju Chen,John C. Arnold,Mary P. Fairchok,Mary P. Fairchok,Mary P. Fairchok,Patrick Danaher,Tahaniyat Lalani,Tahaniyat Lalani,Leslie Malone,Deepika Mor,Deepika Mor,Michelande Ridore,Timothy Burgess,Eugene V. Millar,Eugene V. Millar +16 more
TL;DR: Human coronavirus (HCoV) is a known cause of influenza‐like illness (ILI), and in a multisite, observational, longitudinal study of ILI among otherwise healthy adolescents and adults, 12% of subjects were PCR‐positive for HCoV.
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Mitigating Future Respiratory Virus Pandemics: New Threats and Approaches to Consider.
TL;DR: In this article, the authors discuss the most common respiratory virus threats, current efforts at early emerging pathogen detection, and propose and defend new molecular pathogen discovery strategies with the goal of preempting future pandemics.
References
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Clustal w: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
TL;DR: The sensitivity of the commonly used progressive multiple sequence alignment method has been greatly improved and modifications are incorporated into a new program, CLUSTAL W, which is freely available.
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The neighbor-joining method: a new method for reconstructing phylogenetic trees.
Naruya Saitou,Masatoshi Nei +1 more
TL;DR: The neighbor-joining method and Sattath and Tversky's method are shown to be generally better than the other methods for reconstructing phylogenetic trees from evolutionary distance data.
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Confidence limits on phylogenies: an approach using the bootstrap.
TL;DR: The recently‐developed statistical method known as the “bootstrap” can be used to place confidence intervals on phylogenies and shows significant evidence for a group if it is defined by three or more characters.
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MEGA5: Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods
Koichiro Tamura,Daniel S. Peterson,Nicholas Peterson,Glen Stecher,Masatoshi Nei,Sudhir Kumar +5 more
TL;DR: The newest addition in MEGA5 is a collection of maximum likelihood (ML) analyses for inferring evolutionary trees, selecting best-fit substitution models, inferring ancestral states and sequences, and estimating evolutionary rates site-by-site.
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Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.