Journal ArticleDOI
Hydrogen sulfide: role in vascular physiology and pathology
TLDR
H2S has a key role in vascular homeostasis during physiology and in pathological states and H2S-based therapies may have a role in several vascular diseases.Abstract:
Purpose of reviewHydrogen sulfide (H2S), a colorless gas that is endogenously generated in mammals from cysteine, has important biological functions. Within the vasculature it regulates vessel tone and outgrowth of new vessels. This review summarizes recent literature on H2S signaling in the vasculature and its therapeutic potential in vascular disordersRecent findingsH(2)S is able to induce vasorelaxation via ATP-sensitive potassium channels in vascular smooth muscle cells. Large-conductance calcium-dependent K+-channels and K-v7 voltage-gated K+-channels are also involved in H2S signaling. Vascular endothelial growth factor is the key downstream mediator that is involved in H2S induced angiogenesis. By having both direct effects on its receptor and increasing the bioavailability of vascular endothelial growth factor, H2S is proangiogenic. H2S-based therapies in vascular diseases are an expanding area of research. The applications of several compounds, such as natural donors and synthetic slow release compounds, have been extensively studied in vascular diseases such as hypertension, ischemia-reperfusion disorders and preeclampsia.SummaryH(2)S has a key role in vascular homeostasis during physiology and in pathological states. H2S-based therapies may have a role in several vascular diseases.read more
Citations
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Oxidative Stress in Preeclampsia and Placental Diseases.
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Luminescent gold nanocluster-based sensing platform for accurate H2S detection in vitro and in vivo with improved anti-interference.
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Biomedical Applications for Gold Nanoclusters: Recent Developments and Future Perspectives
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Physiological Importance of Hydrogen Sulfide: Emerging Potent Neuroprotector and Neuromodulator
TL;DR: The primary purpose of this review was to provide an overview of the role of H2S in the human body and to describe its beneficial effects.
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Sulphurous Mineral Waters: New Applications for Health.
TL;DR: The chemistry and actions of hydrogen sulphide in sulphurous mineral waters and its natural role in body physiology are reviewed followed by an update of available data on the impacts of exogenous hydrogen sulphides on the skin and internal cells and organs.
References
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Journal ArticleDOI
H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
Guangdong Yang,Guangdong Yang,Lingyun Wu,Bo Jiang,Wei Yang,Jiansong Qi,Kun Cao,Qinghe Meng,Asif K. Mustafa,Weitong Mu,Shengming Zhang,Solomon H. Snyder,Rui Wang,Rui Wang +13 more
TL;DR: It is shown that H2S is physiologically generated by cystathionine γ-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H 2S levels in the serum, heart, aorta, and other tissues.
Journal ArticleDOI
The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener
TL;DR: It is demonstrated that H2S is an important endogenous vasoactive factor and the first identified gaseous opener of KATP channels in vascular SMCs and production from vascular tissues was enhanced by nitric oxide.
Journal ArticleDOI
Relaxation of arterial smooth muscle by calcium sparks
Mark T. Nelson,Heping Cheng,Michael Rubart,Luis Fernando Santana,Adrian D. Bonev,Harm J. Knot,W. J. Lederer +6 more
TL;DR: KCa channels activated by Ca2+ sparks appeared to hyperpolarize and dilate pressurized myogenic arteries because ryanodine and thapsigargin depolarized and constricted these arteries to an extent similar to that produced by blockers of KCa channels.
Journal ArticleDOI
Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases
Vera Eremina,Manish M. Sood,Jody J. Haigh,Andras Nagy,Ginette Lajoie,Napoleone Ferrara,Hans-Peter Gerber,Yamato Kikkawa,Jeffrey H. Miner,Susan E. Quaggin +9 more
TL;DR: The data demonstrate that tight regulation of VEGF-A signaling is critical for establishment and maintenance of the glomerular filtration barrier and strongly supports a pivotal role for VEGf-A in renal disease.
Journal ArticleDOI
Hydrogen sulfide is an endogenous stimulator of angiogenesis
Andreas Papapetropoulos,Anastasia Pyriochou,Zaid Altaany,Guangdong Yang,Antonia Marazioti,Zongmin Zhou,Mark G. Jeschke,Ludwik K. Branski,David N. Herndon,Rui Wang,Csaba Szabó,Csaba Szabó +11 more
TL;DR: Investigation of the role of exogenous and endogenous hydrogen sulfide on neovascularization and wound healing in vitro and in vivo concludes that endogenous and exogenous H2S stimulates EC-related angiogenic properties through a KATP channel/MAPK pathway.
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