Hypercoagulability in response to elevated body temperature and central hypovolemia
Martin A. S. Meyer,Martin A. S. Meyer,Sisse R. Ostrowski,Anders Overgaard,Matthew S. Ganio,Matthew S. Ganio,Matthew S. Ganio,Niels H. Secher,Craig G. Crandall,Craig G. Crandall,Pär I. Johansson,Pär I. Johansson +11 more
TLDR
It is hypothesize that elevated body temperature and reduced CBV contributes to hypercoagulability, possibly due to moderate sympathetic activation, in critically ill patients and speculate that normalization of bodyTemperature and CBV may attenuate this hyper coagulable response.About:
This article is published in Journal of Surgical Research.The article was published on 2013-12-01 and is currently open access. It has received 34 citations till now. The article focuses on the topics: Hemostasis & Hypovolemia.read more
Citations
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Hyperinflammation and derangement of renin-angiotensin-aldosterone system in COVID-19: A novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis.
TL;DR: The underlying pathogenesis and the interaction between multiple systems, resulting in propagation of immunothrombosis, are discussed and may lead to both an improved understanding of COVID-19 pathophysiology and identification of innovative and efficient therapeutic targets to reverse the otherwise unfavorable clinical outcome of many of these patients.
OtherDOI
Human Cardiovascular Responses to Passive Heat Stress
Craig G. Crandall,Thad E. Wilson +1 more
TL;DR: Understanding the mechanisms within this complex regulatory system will allow for the development of treatment recommendations and countermeasures to reduce risks during the ever-increasing frequency of severe heat events that are predicted to occur.
Journal ArticleDOI
The four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-2 infection (COVID-19).
TL;DR: The pathogenesis of coronavirus disease 2019 (COVID-19) may be envisaged as the dynamic interaction between four vicious feedback loops chained or happening at once, which are the viral loop, the hyperinflammatoryloop, the non-canonical renin-angiotensin system (RAS) axis loop, and the hypercoagulation loop.
Journal ArticleDOI
Physiological factors characterizing heat-vulnerable older adults: A narrative review.
Robert D. Meade,Ashley P. Akerman,Sean R. Notley,Ryan McGinn,Paul Poirier,Pierre Gosselin,Glen P. Kenny,Glen P. Kenny +7 more
TL;DR: Current understanding of the physiological mechanisms by which aging impairs the regulation of body temperature, hemodynamic stability and hydration status is summarized and how age-associated chronic health conditions may exacerbate those impairments are examined.
Journal ArticleDOI
Intraoperative modifiable risk factors of colorectal anastomotic leakage: Why surgeons and anesthesiologists should act together
S. J. van Rooijen,Daitlin E Huisman,M. Stuijvenberg,Jurre Stens,Rudi M. H. Roumen,F. Daams,Gerrit D. Slooter +6 more
TL;DR: Both surgery related and non-surgery related risk factors that can be modified must be identified to improve colorectal care.
References
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Roger C. Bone,Robert A. Balk,F. B. Cerra,R. P. Dellinger,A. M. Fein,William A. Knaus,Roland M. H. Schein,W. J. Sibbald +7 more
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TL;DR: A review of state-of-the-art knowledge on the composition and functions of the endothelial glycocalyx can be found in this article, where the contribution of the glyocalyx to diabetes, ischemia/reperfusion, and atherosclerosis is also reviewed.
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Karim Brohi,Mitchell J. Cohen,Michael T. Ganter,Marcus J. Schultz,Marcel Levi,Robert C. Mackersie,Jean-Francois Pittet +6 more
TL;DR: Acute coagulopathy of trauma is associated with systemic hypoperfusion and is characterized by anticoagulation and hyperfibrinolysis, which correlates with thrombomodulin activity.
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