Journal ArticleDOI
Hypermethylation of HIC1 Promoter and Aberrant Expression of HIC1/SIRT1 Might Contribute to the Carcinogenesis of Pancreatic Cancer
Gang Zhao,Qi Qin,Jun-gang Zhang,Yang Liu,Shi-chang Deng,Lin Liu,Bo Wang,Kui Tian,Chunyou Wang +8 more
TLDR
The results indicate that hypermethylation of HIC1 promoter in CP may contribute to the aberrant expression of H IC1/SIRT1 pathway and then involve in the pancreatic carcinogenesis.Abstract:
Background
DNA hypermethylation is proved to be involved in carcinogenesis. Because chronic pancreatitis (CP) is a consistent risk factor for pancreatic cancer, the possible alteration and tumor contribute effects of hypermethylated in cancer-1 (HIC1) promoter methylation in CP was investigated.read more
Citations
More filters
Journal ArticleDOI
Chronic pancreatitis and pancreatic cancer demonstrate active epithelial-mesenchymal transition profile, regulated by miR-217-SIRT1 pathway.
Shichang Deng,Shuai Zhu,Bo Wang,Xiang Li,Yang Liu,Qi Qin,Qiong Gong,Yi Niu,Cheng Xiang,Jingyuan Chen,Jin Yan,Shijiang Deng,Tao Yin,Ming Yang,Heshui Wu,Chunyou Wang,Gang Zhao +16 more
TL;DR: The results suggest that the overexpressed TGF-β1 in inflammation triggers the deregulation of the miR-217-SIRT1 pathway and then promotes the EMT process, which might be involved in the tumorigenesis of PC.
Journal ArticleDOI
Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling
Bingqing Huang,Xixi Cheng,Dan Wang,Meiyu Peng,Zhenyi Xue,Yurong Da,Ning Zhang,Zhi Yao,Min Li,Aimin Xu,Rongxin Zhang +10 more
TL;DR: It is found that adiponectin significantly inhibited the apoptosis of both human and mouse pancreatic cancer cells via adipo R1, but not adipoR2, and the effects of adiponECTin on tumorigenesis are highly tissue-dependent.
Journal ArticleDOI
Ectopic expression of miR-494 inhibited the proliferation, invasion and chemoresistance of pancreatic cancer by regulating SIRT1 and c-Myc.
Yan Liu,Xiang Li,Shuai Zhu,Jun-gang Zhang,Ming Yang,Qi Qin,Shijiang Deng,Bo Wang,Kui Tian,Lei Liu,Yi Niu,Chunyou Wang,Gang Zhao +12 more
TL;DR: The clinical characteristics revealed that low miR-494 correlated with larger tumor size, late tumor node metastasis stage, lymphatic invasion, distant metastasis and poor prognosis, which indicated that miD-494 might serve as predictor and inhibitor in PC by directy downregulating the loop of c-Myc and SIRT1.
Journal ArticleDOI
Sirtuins and Cancer: Role in the Epithelial-Mesenchymal Transition.
Raffaele Palmirotta,Mauro Cives,David Della-Morte,Barbara Capuani,Davide Lauro,Fiorella Guadagni,Franco Silvestris +6 more
TL;DR: Though commonly regarded as EMT inducers, sirtuins may also suppress this process, and their functional properties seem to largely depend on the cellular context, stage of cancer development, tissue of origin, and microenvironment architecture.
Journal ArticleDOI
Zwitterion-functionalized dendrimer-entrapped gold nanoparticles for serum-enhanced gene delivery to inhibit cancer cell metastasis.
Zhijuan Xiong,Carla S. Alves,Jianhua Wang,Aijun Li,Jinyuan Liu,Mingwu Shen,João Rodrigues,Helena Tomás,Xiangyang Shi,Xiangyang Shi +9 more
TL;DR: Wound healing and hypermethylated in cancer 1 (HIC1) protein expression assay data reveal that the expression of HIC1 gene in cancer cells enables effective inhibition of cell migration and metastasis in vitro.
References
More filters
Book
AJCC Cancer Staging Manual
Mahul B. Amin,Stephen B. Edge,Frederick L. Greene,David R. Byrd,Robert K. Brookland,Mary Kay Washington,Jeffrey E. Gershenwald,Carolyn C. Compton,Kenneth R. Hess,Daniel C. Sullivan,J. Milburn Jessup,James D. Brierley,Lauri E. Gaspar,Richard L. Schilsky,Charles M. Balch,David P. Winchester,Elliot A. Asare,Martin Madera,Donna M. Gress,Laura R. Meyer +19 more
TL;DR: Purposes and Principles of Cancer Staging and End-Results Reporting are explained.
Journal ArticleDOI
Pancreatitis and the risk of pancreatic cancer
Albert B. Lowenfels,Patrick Maisonneuve,Giorgio Cavallini,Rudolf W. Ammann,Paul Georg Lankisch,Jens Rikardt Andersen,Eugene P. DiMagno,Åke Andrén-Sandberg,Lennart Domellof +8 more
TL;DR: A multicenter historical cohort study of 2015 subjects with chronic pancreatitis who were recruited from clinical centers in six countries finds that pancreatitis may be a risk factor for pancreatic cancer, but the magnitude of the relation between these two diseases is unclear.
Journal ArticleDOI
Recent progress in the biology and physiology of sirtuins
TL;DR: The recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long the authors live are reviewed.
Journal ArticleDOI
Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses
TL;DR: It is shown that the mechanism by which the loss of HIC1 function promotes tumorigenesis is via activating the stress-controlling protein SIRT1 and thereby attenuating p53 function, which deacetylates and inactivates p53, allowing cells to bypass apoptosis and survive DNA damage.