Journal ArticleDOI
Pancreatitis and the risk of pancreatic cancer
Albert B. Lowenfels,Patrick Maisonneuve,Giorgio Cavallini,Rudolf W. Ammann,Paul Georg Lankisch,Jens Rikardt Andersen,Eugene P. DiMagno,Åke Andrén-Sandberg,Lennart Domellof +8 more
TLDR
A multicenter historical cohort study of 2015 subjects with chronic pancreatitis who were recruited from clinical centers in six countries finds that pancreatitis may be a risk factor for pancreatic cancer, but the magnitude of the relation between these two diseases is unclear.Abstract:
Background The results of case-control studies and anecdotal reports suggest that pancreatitis may be a risk factor for pancreatic cancer, but there have been no studies of sufficient size and power to assess the magnitude of the relation between these two diseases. Methods and Results We undertook a multicenter historical cohort study of 2015 subjects with chronic pancreatitis who were recruited from clinical centers in six countries. A total of 56 cancers were identified among these patients during a mean (±SD) follow-up of 7.4 ±6.2 years. The expected number of cases of cancer calculated from country-specific incidence data and adjusted for age and sex was 2.13, yielding a standardized incidence ratio (the ratio of observed to expected cases) of 26.3 (95 percent confidence interval, 19.9 to 34.2). For subjects with a minimum of two or five years of follow-up, the respective standardized incidence ratios were 16.5 (95 percent confidence interval, 11.1 to 23.7) and 14.4 (95 percent confidence interval, 8...read more
Citations
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Oxidative Stress, Inflammation, and Cancer: How Are They Linked?
TL;DR: Observations to date suggest that oxidative stress, chronic inflammation, and cancer are closely linked.
Journal ArticleDOI
Reactive oxygen species in cancer
Geou Yarh Liou,Peter Storz +1 more
TL;DR: The generation of ROS within tumour cells, their detoxification, their cellular effects, as well as the major signalling cascades they utilize are discussed, but also an outlook on their modulation in therapeutics is provided.
Journal ArticleDOI
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Sunil R. Hingorani,Emanuel F. Petricoin,Anirban Maitra,Vinodh N. Rajapakse,Catrina King,Michael A. Jacobetz,Sally Ross,Thomas P. Conrads,Timothy D. Veenstra,Ben A. Hitt,Yoshiya Kawaguchi,Donald J. Johann,Lance A. Liotta,Howard C. Crawford,Mary E. Putt,Tyler Jacks,Christopher V.E. Wright,Ralph H. Hruban,Andrew M. Lowy,David A. Tuveson +19 more
TL;DR: It is found that physiological levels of Kras(G12D) induce ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs), putative precursors to invasive pancreatic cancer.
Journal ArticleDOI
Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors.
TL;DR: Up-to-date statistics on pancreatic cancer occurrence and outcome along with a better understanding of the etiology and identifying the causative risk factors are essential for the primary prevention of this disease.
Journal ArticleDOI
Chronic pancreatitis: Diagnosis, classification, and new genetic developments
Babak Etemad,David C. Whitcomb +1 more
TL;DR: It is concluded that an adequate pancreatic biopsy must be the gold standard against which all diagnostic approaches are judged and the roles of endoscopic retrograde pancreatography, endoscopic ultrasonography, and magnetic resonance imaging are considered.
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