Hypoalbuminemia predicts the outcome of COVID-19 independent of age and co-morbidity.
TLDR
Hypoalbuminemia is associated with the outcome of COVID‐19 and the potential therapeutic value of albumin infusion in CO VID‐19 should be further explored at the earliest.Abstract:
The coronavirus disease 2019 (COVID-19) has evolved into a pandemic rapidly. Most of the literature show that the elevated liver enzymes in COVID-19 are of little clinical significance. Lower albumin level is seen in severe COVID-19 and is not parallel to the changes in alanine aminotransferase and aspartate aminotransferase levels. We aimed to explore the impact of hypoalbuminemia in COVID-19. This retrospective cohort study included adult patients with confirmed COVID-19. The relationship between hypoalbuminemia and death was studied using binary logistic analysis. A total of 299 adult patients were included, 160 (53.5%) were males and the average age was 53.4 ± 16.7 years. The median time from the onset of illness to admission was 3 days (interquartile ranges, 2-5). Approximately one-third of the patients had comorbidities. Hypoalbuminemia (<35 g/L) was found in 106 (35.5%) patients. The difference in albumin was considerable between survivors and non-survivors (37.6 ± 6.2 vs 30.5 ± 4.0, P < .001). Serum albumin level was inversely correlated to white blood cell (r = -.149, P = .01) and neutrophil to lymphocyte ratio (r = -.298, P < .001). Multivariate analysis showed the presence of comorbidities (OR, 6.816; 95% CI, 1.361-34.133), lymphopenia (OR, 13.130; 95% CI, 1.632-105.658) and hypoalbuminemia (OR, 6.394; 95% CI, 1.315-31.092) were independent predictive factors for mortality. In conclusion, hypoalbuminemia is associated with the outcome of COVID-19. The potential therapeutic value of albumin infusion in COVID-19 should be further explored at the earliest.read more
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
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Predictors of COVID-19 severity: A literature review.
Benjamin Gallo Marin,Ghazal Aghagoli,Katya Lavine,Lanbo Yang,Emily J. Siff,Silvia S. Chiang,Silvia S. Chiang,Thais P. Salazar-Mather,Luba Dumenco,Michael C Savaria,Su Aung,Timothy P. Flanigan,Ian C. Michelow,Ian C. Michelow +13 more
TL;DR: A synthesis of the current literature pertaining to factors predictive of COVID‐19 clinical course and outcomes shows findings associated with increased disease severity and/or mortality include age, multiple pre‐existing comorbidities, hypoxia, specific computed tomography findings indicative of extensive lung involvement, diverse laboratory test abnormalities, and biomarkers of end‐organ dysfunction.
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Abnormal Liver Function Tests in Patients With COVID-19: Relevance and Potential Pathogenesis.
Anna Bertolini,Ivo P van de Peppel,Frank A J A Bodewes,Han Moshage,Alberto Fantin,Fabio Farinati,Romina Fiorotto,Johan W. Jonker,Mario Strazzabosco,Henkjan J. Verkade,G. Peserico +10 more
TL;DR: The prevalence of abnormal LFTs is high in COVID‐19 patients, but that the clinical relevance is limited and that treatment is not required, and the mechanisms underlying abnormal L FTs are likely multifactorial and related to a hyper‐inflammatory status and thrombotic microangiopathy that are observed in severe CO VID‐19 disease.
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Predictors of in-hospital COVID-19 mortality: A comprehensive systematic review and meta-analysis exploring differences by age, sex and health conditions.
Arthur Eumann Mesas,Arthur Eumann Mesas,Iván Cavero-Redondo,Iván Cavero-Redondo,Celia Álvarez-Bueno,Celia Álvarez-Bueno,Marcos Aparecido Sarria Cabrera,Selma Maffei de Andrade,Irene Sequí-Domínguez,Vicente Martínez-Vizcaíno,Vicente Martínez-Vizcaíno +10 more
TL;DR: The prognostic effect of clinical conditions on COVID-19 mortality vary substantially according to the mean age of patients, and age was the main source of heterogeneity, followed by sex and health condition.
Journal ArticleDOI
Neutrophil-to-lymphocyte ratio on admission to predict the severity and mortality of COVID-19 patients: A meta-analysis.
TL;DR: High NLR levels on admission were associated with severe COVID-19 and mortality, and further studies need to focus on determining the optimal cut-off value for NLR before clinical use.
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TL;DR: It is found that among laboratory confirmed cases of COVID-19, patients with any comorbidity yielded poorer clinical outcomes than those without and a greater number ofComorbidities also correlated with poorer clinical outcome.
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