Journal ArticleDOI
Ibuprofen-based advanced therapeutics: breaking the inflammatory link in cancer, neurodegeneration, and diseases.
Arun Upadhyay,Ayeman Amanullah,Vibhuti Joshi,Rohan Dhiman,Vijay Kumar Prajapati,Krishna Mohan Poluri,Amit Mishra +6 more
TLDR
Ibuprofen is a classical nonsteroidal anti-inflammatory drug (NSAID) highly prescribed to reduce acute pain and inflammation under an array of conditions, including rheumatoid arthritis, osteoarthritis, dysmenorrhea, and gout.Abstract:
Ibuprofen is a classical nonsteroidal anti-inflammatory drug (NSAID) highly prescribed to reduce acute pain and inflammation under an array of conditions, including rheumatoid arthritis, osteoarthritis, dysmenorrhea, and gout. Ibuprofen acts as a potential inhibitor for cyclooxygenase enzymes (COX-1 and COX-2). In the past few decades, research on this small molecule has led to identifying other possible therapeutic benefits. Anti-tumorigenic and neuroprotective functions of Ibuprofen are majorly recognized in recent literature and need further consideration. Additionally, several other roles of this anti-inflammatory molecule have been discovered and subjected to experimental assessment in various diseases. However, the major challenge faced by Ibuprofen and other drugs of similar classes is their side effects, and tendency to cause gastrointestinal injury, generate cardiovascular risks, modulate hepatic and acute kidney diseases. Future research should also be conducted to deduce new methods and approaches of suppressing the unwanted toxic changes mediated by these drugs and develop new therapeutic avenues so that these small molecules continue to serve the purposes. This article primarily aims to develop a comprehensive and better understanding of Ibuprofen, its pharmacological features, therapeutic benefits, and possible but less understood medicinal properties apart from major challenges in its future application.KEY POINTSIbuprofen, an NSAID, is a classical anti-inflammatory therapeutic agent.Pro-apoptotic roles of NSAIDs have been explored in detail in the past, holding the key in anti-cancer therapies.Excessive and continuous use of NSAIDs may have several side effects and multiple organ damage.Hyperactivated Inflammation initiates multifold detrimental changes in multiple pathological conditions.Targeting inflammatory pathways hold the key to several therapeutic strategies against many diseases, including cancer, microbial infections, multiple sclerosis, and many other brain diseases.read more
Citations
More filters
Journal ArticleDOI
Elucidating the Neuroprotective Role of PPARs in Parkinson's Disease: A Neoteric and Prospective Target.
Tapan Behl,Piyush Madaan,Aayush Sehgal,Sukhbir Singh,Neelam Sharma,Saurabh Bhatia,Ahmed Al-Harrasi,Sridevi Chigurupati,Ibrahim Alrashdi,Simona Bungau +9 more
TL;DR: In this article, a review of the emerging evidence enlightening the neuroprotective outcomes of PPAR agonists in in vivo and in vitro models experiencing Parkinson's disease is presented.
Journal ArticleDOI
Novel 1,3-diaryl pyrazole derivatives bearing methylsulfonyl moiety: Design, synthesis, molecular docking and dynamics, with dual activities as anti-inflammatory and anticancer agents through selectively targeting COX-2.
Ahmed M. M. Shaker,Mai I. Shahin,Asmaa M. AboulMagd,Seham A. Abd-El-Aleem,Hamdy M. Abdel-Rahman,Dalal A. Abou El Ella +5 more
TL;DR: In this article , a series of novel 1-aryl-3-(4-methylsulfonylphenyl) pyrazole derivatives were synthesized, characterized by several spectroscopic techniques, and investigated as potential anti-inflammatory and anticancer agents.
Journal ArticleDOI
Synthesis of Ibuprofen Monoglyceride Using Novozym®435: Biocatalyst Activation and Stabilization in Multiphasic Systems
TL;DR: In this paper , the authors focused on the enzymatic esterification of glycerol and ibuprofen at high concentrations in two triphasic systems composed of toluene+ibuprofene (apolar) liquid phases, and a solid phase with the industrial immobilized lipase B from Candida antarctica named Novozym®435 (N435) acting as the biocatalyst.
Journal ArticleDOI
Zwitterion‐Catalyzed Ring‐Opening of Epoxides with Carboxylic Acids
Journal ArticleDOI
The Effects of 2′-Hydroxy-3,6′-Dimethoxychalcone on Melanogenesis and Inflammation
Su Mi Bae,Chang-Gu Hyun +1 more
TL;DR: In this article , the effect of 3,6′-dimethoxychalcone on melanogenesis and lipopolysaccharides (LPS)-induced inflammation in mouse B16F10 and RAW 264.7 cells was investigated.
References
More filters
Journal Article
A postgenomic integrated view of prostaglandins in reproduction: implications for other body systems.
TL;DR: An integrated view of PG action based on observations in the female reproductive system, but with potential strategic implications for cardiovascular and metabolic complications is presented.
Journal ArticleDOI
Ibuprofen overdose: 126 cases
Alan H. Hall,Susan C. Smolinske,Frances L. Conrad,Kathleen M. Wruk,Kenneth W. Kulig,Terry L Dwelle,Barry H. Rumack +6 more
TL;DR: Signs and symptoms of central nervous system depression, seizures, gastrointestinal disturbances, bradycardia, hypotension, apnea, abnormal renal functions, hematuria, nystagmus, and blurred vision were observed after ibuprofen overdose.
Journal ArticleDOI
Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease
Brandy L. Wilkinson,Paige E. Cramer,Nicholas H. Varvel,Nicholas H. Varvel,Erin G. Reed-Geaghan,Qingguang Jiang,Alison Szabo,Karl Herrup,Bruce T. Lamb,Bruce T. Lamb,Gary E. Landreth +10 more
TL;DR: It is suggested that ibuprofen acts independently of cyclooxygenase COX inhibition to disrupt signaling cascades leading to microglial NADPH oxidase (NOX2) activation, preventing oxidative damage and enhancing plaque clearance in the brain.
Journal ArticleDOI
MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis.
Patsy Clark,Steven E. Rowland,Danielle Denis,Marie-Claude Mathieu,Rino Stocco,Hugo Poirier,Jason Burch,Yongxin Han,Laurent P. Audoly,Alex G. Therien,Daigen Xu +10 more
TL;DR: The results suggest that EP4 is the major EP receptor in both RA and OA but also provide a proof of principle to the concept that antagonism of EP4 may be useful for treatment of arthritis.
Journal ArticleDOI
Do non-steroidal anti-inflammatory drugs adversely affect stress fracture healing? A short review
Patrick C. Wheeler,Mark E. Batt +1 more
TL;DR: Research is required to investigate whether the healing of stress fractures is affected by these drugs, in view of the high usage of NSAIDs in treating musculoskeletal disorders.
Related Papers (5)
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Other Anti- Inflammatory Agents in the Treatment of Neurodegenerative Disease
Andis Klegeris,Patrick L. McGeer +1 more
Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond
P.N. Praveen Rao,Edward E. Knaus +1 more