Journal ArticleDOI
Ibuprofen-based advanced therapeutics: breaking the inflammatory link in cancer, neurodegeneration, and diseases.
Arun Upadhyay,Ayeman Amanullah,Vibhuti Joshi,Rohan Dhiman,Vijay Kumar Prajapati,Krishna Mohan Poluri,Amit Mishra +6 more
TLDR
Ibuprofen is a classical nonsteroidal anti-inflammatory drug (NSAID) highly prescribed to reduce acute pain and inflammation under an array of conditions, including rheumatoid arthritis, osteoarthritis, dysmenorrhea, and gout.Abstract:
Ibuprofen is a classical nonsteroidal anti-inflammatory drug (NSAID) highly prescribed to reduce acute pain and inflammation under an array of conditions, including rheumatoid arthritis, osteoarthritis, dysmenorrhea, and gout. Ibuprofen acts as a potential inhibitor for cyclooxygenase enzymes (COX-1 and COX-2). In the past few decades, research on this small molecule has led to identifying other possible therapeutic benefits. Anti-tumorigenic and neuroprotective functions of Ibuprofen are majorly recognized in recent literature and need further consideration. Additionally, several other roles of this anti-inflammatory molecule have been discovered and subjected to experimental assessment in various diseases. However, the major challenge faced by Ibuprofen and other drugs of similar classes is their side effects, and tendency to cause gastrointestinal injury, generate cardiovascular risks, modulate hepatic and acute kidney diseases. Future research should also be conducted to deduce new methods and approaches of suppressing the unwanted toxic changes mediated by these drugs and develop new therapeutic avenues so that these small molecules continue to serve the purposes. This article primarily aims to develop a comprehensive and better understanding of Ibuprofen, its pharmacological features, therapeutic benefits, and possible but less understood medicinal properties apart from major challenges in its future application.KEY POINTSIbuprofen, an NSAID, is a classical anti-inflammatory therapeutic agent.Pro-apoptotic roles of NSAIDs have been explored in detail in the past, holding the key in anti-cancer therapies.Excessive and continuous use of NSAIDs may have several side effects and multiple organ damage.Hyperactivated Inflammation initiates multifold detrimental changes in multiple pathological conditions.Targeting inflammatory pathways hold the key to several therapeutic strategies against many diseases, including cancer, microbial infections, multiple sclerosis, and many other brain diseases.read more
Citations
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Elucidating the Neuroprotective Role of PPARs in Parkinson's Disease: A Neoteric and Prospective Target.
Tapan Behl,Piyush Madaan,Aayush Sehgal,Sukhbir Singh,Neelam Sharma,Saurabh Bhatia,Ahmed Al-Harrasi,Sridevi Chigurupati,Ibrahim Alrashdi,Simona Bungau +9 more
TL;DR: In this article, a review of the emerging evidence enlightening the neuroprotective outcomes of PPAR agonists in in vivo and in vitro models experiencing Parkinson's disease is presented.
Journal ArticleDOI
Novel 1,3-diaryl pyrazole derivatives bearing methylsulfonyl moiety: Design, synthesis, molecular docking and dynamics, with dual activities as anti-inflammatory and anticancer agents through selectively targeting COX-2.
Ahmed M. M. Shaker,Mai I. Shahin,Asmaa M. AboulMagd,Seham A. Abd-El-Aleem,Hamdy M. Abdel-Rahman,Dalal A. Abou El Ella +5 more
TL;DR: In this article , a series of novel 1-aryl-3-(4-methylsulfonylphenyl) pyrazole derivatives were synthesized, characterized by several spectroscopic techniques, and investigated as potential anti-inflammatory and anticancer agents.
Journal ArticleDOI
Synthesis of Ibuprofen Monoglyceride Using Novozym®435: Biocatalyst Activation and Stabilization in Multiphasic Systems
TL;DR: In this paper , the authors focused on the enzymatic esterification of glycerol and ibuprofen at high concentrations in two triphasic systems composed of toluene+ibuprofene (apolar) liquid phases, and a solid phase with the industrial immobilized lipase B from Candida antarctica named Novozym®435 (N435) acting as the biocatalyst.
Journal ArticleDOI
Zwitterion‐Catalyzed Ring‐Opening of Epoxides with Carboxylic Acids
Journal ArticleDOI
The Effects of 2′-Hydroxy-3,6′-Dimethoxychalcone on Melanogenesis and Inflammation
Su Mi Bae,Chang-Gu Hyun +1 more
TL;DR: In this article , the effect of 3,6′-dimethoxychalcone on melanogenesis and lipopolysaccharides (LPS)-induced inflammation in mouse B16F10 and RAW 264.7 cells was investigated.
References
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Journal ArticleDOI
Ibuprofen-induced hypersensitivity syndrome
Radu M. Nanau,Manuela G. Neuman +1 more
TL;DR: An ibuprofen-induced clinical manifestation of hypersensitivity syndrome is presented and the necessity of wisely monitoring the patients clinically and by laboratory investigations when prescribing this drug is presented.
Journal ArticleDOI
Ibuprofen and skin and soft tissue superinfections in children with varicella
TL;DR: The results of this study are consistent with a broad range of effects including no association and suggest that further study is needed.
Journal ArticleDOI
Predictability of Metabolism of Ibuprofen and Naproxen Using Chimeric Mice with Human Hepatocytes
Seigo Sanoh,Aya Horiguchi,Kazumi Sugihara,Yaichiro Kotake,Yoshitaka Tayama,Naoto Uramaru,Hiroki Ohshita,Chise Tateno,Toru Horie,Shigeyuki Kitamura,Shigeru Ohta +10 more
TL;DR: Results indicated that h-PXB mice should be helpful for predicting the quantitative metabolic profiles of drugs mediated by P450 and non-P450 in liver, and r-P XB mice ought to behelp for evaluation of species differences in these metabolic enzymes.
Journal ArticleDOI
Changes in the gene expression profile of gastric cancer cells in response to ibuprofen: a gene pathway analysis
P. Bonelli,Fm Tuccillo,R Calemma,Furio Pezzetti,Antonella Borrelli,Rosanna Martinelli,A. De Rosa,D Esposito,Raffaele Palaia,G. Castello +9 more
TL;DR: It is suggested that ibuprofen exerts its antiproliferative actions through cell-cycle control and the induction of apoptosis, both of these mechanisms appear to be independent of ib uprofen's anti-inflammatory effects.
Journal ArticleDOI
A re-assessment of the effects of treatment with a non-steroidal anti-inflammatory (ibuprofen) on promoting axon regeneration via RhoA inhibition after spinal cord injury
TL;DR: The results only partially replicate the findings that treatment with ibuprofen improves motor function after SCI but fail to replicate findings regarding enhanced axon growth.
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