Journal ArticleDOI
Immune checkpoint inhibitors for triple-negative breast cancer: From immunological mechanisms to clinical evidence
TLDR
In this paper, the authors provide information on the mechanisms of action of ICIs, review the efficacy results of clinical trials using ICIs for TNBC treatment, and assess the side effects of such drugs.About:
This article is published in International Immunopharmacology.The article was published on 2021-06-16. It has received 10 citations till now. The article focuses on the topics: Immune checkpoint & Triple-negative breast cancer.read more
Citations
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Black Phosphorus, an Emerging Versatile Nanoplatform for Cancer Immunotherapy.
TL;DR: In this paper, a photothermal agent based on black phosphorus nanosheets (BPNSs) and quantum dots (BPQDs) is proposed for photodynamic therapy (PDT).
Journal ArticleDOI
KEYNOTE-522, IMpassion031 and GeparNUEVO: changing the paradigm of neoadjuvant immune checkpoint inhibitors in early triple-negative breast cancer.
A. Rizzo,A. Cusmai,Silvana Acquafredda,Francesco Giovannelli,Luciana Rinaldi,A. Misino,G. Palmiotti +6 more
TL;DR: An overview of recent clinical studies of neoadjuvant immune checkpoint inhibitors in patients with triple-negative breast cancer, especially focusing on the recently presented and published KEYNOTE-522, IMpassion031 and GeparNUEVO trials is provided.
Journal ArticleDOI
Roles of HLA-G/KIR2DL4 in Breast Cancer Immune Microenvironment
Guoxu Zheng,Li Jia,Anderson Yang +2 more
TL;DR: The previous study had shown that HLA-G was a pivotal mediator of breast cancer resistance to trastuzumab, and blockade of the Hla-G/KIR2DL4 interaction can resensitize breast cancer to trastsimab treatment.
Journal ArticleDOI
Oncoinformatic screening of the gene clusters involved in the HER2-positive breast cancer formation along with the in silico pharmacodynamic profiling of selective long-chain omega-3 fatty acids as the metastatic antagonists.
Arwa Morshed,Salauddin Al Azad,Md. Abdur Rashid Mia,M. F. Uddin,T. Ema,Rukaiya Binte Yeasin,Sanjida Ahmed Srishti,Pallab K. Sarker,Rubaita Younus Aurthi,Farhan Jamil,Nure Sharaf Nower Samia,Partha Biswas,Iffat-Ara Sharmeen,Rasel Ahmed,Mahbuba Siddiquy,Nurunnahar +15 more
Journal ArticleDOI
Tumor Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Human Breast Cancer Are Mediated by PD-L1-S283 and Chemokine Axes
TL;DR: Over-expressed WT-PD-L1 in human TNBC cells and in luminal-A breast cancer cells demonstrated that cell-autonomous PD-L 1 activities lead to increased tumor cell growth, invasion and release of pro-metastatic factors, which were promoted by PD-1 and were inhibited by mutating S283 in PD- L1.
References
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Journal ArticleDOI
Microsatellite instability and mismatch repair protein expressions in lymphocyte‐predominant breast cancer
Yoshiya Horimoto,May Thinzar Hlaing,Harumi Saeki,Shigehisa Kitano,Katsuya Nakai,Ritsuko Sasaki,Aiko Kurisaki-Arakawa,Atsushi Arakawa,Naomi Otsuji,Shuji Matsuoka,Emi Tokuda,Masami Arai,Mitsue Saito +12 more
TL;DR: Tests on triple‐negative breast cancers with a high density of tumor‐infiltrating lymphocytes found that MSI‐H tumors were absent in TIL‐high breast cancers, and examination of MMR proteins and PD‐L1 expression may merit further studies to yield predictive information for identifying patients who are likely to benefit from ICI.
Journal ArticleDOI
PD-L1 expression in tumor infiltrated lymphocytes predicts survival in triple-negative breast cancer.
Xinran Wang,Yueping Liu +1 more
TL;DR: PD-L1 expression in TILs, but not in tumor cells, was a poor prognostic factor in T NBC, providing further impetus for assessing immunotherapy in TNBC.
Journal ArticleDOI
Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients.
Ali Bohlok,Peter B. Vermeulen,Sophia Leduc,Emily Latacz,Lara Botzenhart,Francois Richard,Maxim De Schepper,Tatjana Geukens,Valerio Lucidi,Michail Ignatiadis,Philippe Aftimos,Christos Sotiriou,Martine Piccart,Alain Hendlisz,Steven Van Laere,Luc Dirix,Jean Christophe Noël,Elia Biganzoli,Denis Larsimont,Christine Desmedt,Vincent Donckier +20 more
TL;DR: In this paper, the authors characterized histopathological growth patterns (HGPs) of liver metastases in a consecutive series of 36 breast cancer patients who underwent hepatic surgery.
Journal ArticleDOI
Mismatch Repair Deficiency and Microsatellite Instability in Triple-Negative Breast Cancer: A Retrospective Study of 440 Patients
Xinyu Ren,Yu Song,Jing Wang,Long-Yun Chen,Junyi Pang,Liangrui Zhou,Songjie Shen,Xi Cao,Yu-Xin Wang,Miao-Miao Shao,Zhiyong Liang,Qiang Sun,Huanwen Wu +12 more
TL;DR: In this article, the status of mismatch repair (MMR) and microsatellite instability (MSI) in triple-negative breast cancer (TNBC) was investigated and correlations between MMR/MSI status and clinicopathological parameters and prognosis were analyzed.
Journal ArticleDOI
Multi-panel immunofluorescence analysis of tumor infiltrating lymphocytes in triple negative breast cancer: Evolution of tumor immune profiles and patient prognosis
Ting-Fang He,Susan E. Yost,Paul Frankel,Andrew Dagis,Yu Cao,Roger Wang,Anthony Rosario,Travis Y. Tu,Shawn Solomon,Daniel Schmolze,Joanne E. Mortimer,Peter P. Lee,Yuan Yuan +12 more
TL;DR: Higher PD1+ TILs are associated with better prognosis in early stage TNBCs, and this finding supports the application of immune checkpoint inhibitors early in the treatment of T NBCs.
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