Immune-related adverse events for anti-PD-1 and anti-PD-L1 drugs: systematic review and meta-analysis
Shrujal S. Baxi,Shrujal S. Baxi,Annie Yang,Renee L. Gennarelli,Niloufer Khan,Ziwei Wang,Lindsay M. Boyce,Deborah Korenstein +7 more
TLDR
Organ specific immune-related adverse events are uncommon with anti-PD-1 drugs but the risk is increased compared with control treatments, and general adverse events related to immune activation are largely similar.Citations
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Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-analysis.
Yucai Wang,Shouhao Zhou,Shouhao Zhou,Fang Yang,Xinyue Qi,Xin Wang,Xiaoxiang Guan,Xiaoxiang Guan,Chan Shen,Narjust Duma,Jesus Vera Aguilera,Ashish V. Chintakuntlawar,Katharine A. Price,Julian R. Molina,Lance C. Pagliaro,Thorvardur R. Halfdanarson,Axel Grothey,Axel Grothey,Svetomir N. Markovic,Grzegorz S. Nowakowski,Stephen M. Ansell,Michael L. Wang +21 more
TL;DR: Different PD-1 and PD-L1 inhibitors appear to have varying treatment-related adverse events; a comprehensive summary of the incidences of treatment- related adverse events in clinical trials provides an important guide for clinicians.
Journal ArticleDOI
A randomised phase II study investigating durvalumab in addition to an anthracycline taxane-based neoadjuvant therapy in early triple-negative breast cancer: clinical results and biomarker analysis of GeparNuevo study
S. Loibl,Michael Untch,Nicole Burchardi,J Huober,Bruno Valentin Sinn,J-U Blohmer,EM Grischke,Jenny Furlanetto,Hans Tesch,Claus Hanusch,Knut Engels,Mahdi Rezai,C. Jackisch,Wolfgang D. Schmitt,G. von Minckwitz,Jörg Thomalla,S Kümmel,Beate Rautenberg,PA Fasching,Karsten Weber,K Rhiem,Carsten Denkert,Andreas Schneeweiss +22 more
TL;DR: The results suggest that the addition of durvalumab to anthracycline/taxane based NACT increases pCR rate particularly in patients treated with durvalUMab alone prior to start of chemotherapy.
Journal ArticleDOI
Efficacy of PD-1 or PD-L1 inhibitors and PD-L1 expression status in cancer: meta-analysis.
Xian Shen,Bin Zhao +1 more
TL;DR: It is suggested that PD-L1 expression status alone is insufficient in determining which patients should be offered PD-1 or PD- L1 blockade therapy, which is a preferable treatment option over conventional therapy for both patients that are PD- l1 positive and PD-l1 negative.
Journal ArticleDOI
PD-L1 distribution and perspective for cancer immunotherapy-blockade, knockdown, or inhibition
TL;DR: It is prospect that the more effective PD-L1-based cancer immunotherapy will be combination therapies, based on the understandings of PD- L1 distribution, regulation, and function.
References
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Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
TL;DR: Moher et al. as mentioned in this paper introduce PRISMA, an update of the QUOROM guidelines for reporting systematic reviews and meta-analyses, which is used in this paper.
Journal ArticleDOI
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
TL;DR: A structured summary is provided including, as applicable, background, objectives, data sources, study eligibility criteria, participants, interventions, study appraisal and synthesis methods, results, limitations, conclusions and implications of key findings.
Journal ArticleDOI
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
TL;DR: PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) is introduced, an update of the QUOROM guidelines for reporting systematic reviews and meta-analyses.
Journal ArticleDOI
The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials
Julian P T Higgins,Douglas G. Altman,Peter C Gøtzsche,Peter Jüni,David Moher,Andrew D Oxman,Jelena Savović,Kenneth F. Schulz,Laura Weeks,Jonathan A C Sterne +9 more
TL;DR: The Cochrane Collaboration’s tool for assessing risk of bias aims to make the process clearer and more accurate.
Journal ArticleDOI
Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer
Hossein Borghaei,Luis Paz-Ares,Leora Horn,D. R. Spigel,M. Steins,Neal Ready,L.Q. Chow,Everett E. Vokes,Enriqueta Felip,Esther Holgado,F. Barlesi,M. Kohlhufl,Oscar Arrieta,Marco Angelo Burgio,J. Fayette,H. Lena,Elena Poddubskaya,David E. Gerber,Scott N. Gettinger,Charles M. Rudin,Naiyer A. Rizvi,L. Crina,G. R. Blumenschein,Scott J. Antonia,C. Dorange,C. T. Harbison,F. Graf Finckenstein,Julie R. Brahmer +27 more
TL;DR: Nivolumab was associated with even greater efficacy than docetaxel across all end points in subgroups defined according to prespecified levels of tumor-membrane expression (≥1, ≥5%, and ≥10%) of the PD-1 ligand.
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