Immunohistochemical Approach to the Differential Diagnosis of Meningiomas and Their Mimics.
Camille Boulagnon-Rombi,Clémence Fleury,Caroline Fichel,Sophie Lefour,Aude Bressenot,Guillaume Gauchotte +5 more
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TLDR
SSTR2A, STAT6, and SOX10 were the most sensitive and specific markers to distinguish meningiomas from their morphological mimics.Abstract:
The differential diagnosis between meningioma and others tumors can be challenging. This study aimed to evaluate different immunohistochemical markers for the differential diagnosis between meningioma and their morphological mimics. Immunohistochemistry was performed on tissue microarray with antiepithelial membrane antigen (EMA), progesterone receptor, somatostatin receptor 2A (SSTR2A), CD34, STAT6, S100, SOX10, HMB45, MelanA, GFAP, inhibin, and BCL2 antibodies. One hundred and twenty-seven meningiomas, 26 solitary fibrous tumor/hemangiopericytomas (SFT/HPC), 39 schwannomas, 17 hemangioblastomas, 21 melanomas, 9 gliosarcomas, 5 neurofibromas, 9 peripheral primitive neuroectodermal tumors, 7 synovial sarcomas, and 5 malignant peripheral nerve sheath tumors were included in the microarray. SSTR2A was the most sensitive (95.2%) and specific (92%) marker of meningiomas. In combination, SSTR2A and/or EMA positivity reached maximal sensitivity (100%). Coexpression of SSTR2A and EMA was the most specific (94.8%) for the diagnosis of meningioma, regardless of the grade or subtype, with the exception of the differential diagnosis with synovial sarcoma. All synovial sarcomas were EMA-positive and 6/7 SSTR2A-positive. STAT6 showed optimum sensitivity and specificity (100%) for SFT/HPC. SOX10 was the most sensitive (94.3%) and specific (100%) marker to discriminate meningiomas from schwannomas. In conclusion, SSTR2A, STAT6, and SOX10 were the most sensitive and specific markers to distinguish meningiomas from their morphological mimics.read more
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Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb.
Mona Khan,Seung-Jun Yoo,Marnick Clijsters,Wout Backaert,Arno Vanstapel,Kato Speleman,Charlotte Lietaer,Sumin Choi,Tyler Hether,Lukas Marcelis,Andrew Nam,Liuliu Pan,Jason Reeves,Pauline Van Bulck,Hai Zhou,Marc Bourgeois,Yves Debaveye,Paul De Munter,Jan Gunst,Mark Jorissen,Katrien Lagrou,Natalie Lorent,Arne Neyrinck,Marijke Peetermans,Dietmar Rudolf Thal,Christophe Vandenbriele,Joost Wauters,Peter Mombaerts,Laura Van Gerven +28 more
TL;DR: It is postulate that transient insufficient support from sustentacular cells triggers transient olfactory dysfunction in COVID-19, and SARS-CoV-2 does not appear to be a neurotropic virus.
Journal ArticleDOI
Recent Advances in Meningioma Immunogenetics
TL;DR: In this article, the advances in molecular profiling and immunophenotyping of meningiomas, which may lead to the development of new personalized therapeutic strategies, are discussed, as well as new targeted drug treatments.
Journal ArticleDOI
The Preferred Locations of Meningioma According to Different Biological Characteristics Based on Voxel-Wise Analysis.
Chongran Sun,Zhangqi Dou,Jiawei Wu,Biao Jiang,Yasaman Iranmanesh,Xiaobo Yu,Jianru Li,Hang Zhou,Chen Zhong,Yucong Peng,Jianfeng Zhuang,Qian Yu,Xinyan Wu,Feng Yan,Qi Xie,Gao Chen +15 more
TL;DR: The preferred locations of meningioma could be observed according to different biological characteristics, which might be helpful for clinical decisions.
Journal ArticleDOI
Clinical Significance of Somatostatin Receptor (SSTR) 2 in Meningioma.
TL;DR: Pertinent literature is reviewed to summarize the recent collective knowledge and understanding of SSTR2’s clinical significance in meningioma in this review and offers novel ideas and approaches in the diagnosis, treatment, and prognostic prediction for mening ioma.
Journal ArticleDOI
In situ characterization of stem cells-like biomarkers in meningiomas.
Hanin Alamir,Mona Alomari,Abdulla Ahmed A. Salwati,Mohamad Saka,Mohammed Bangash,Saleh S. Baeesa,Fahad Alghamdi,Angel Carracedo,Angel Carracedo,Hans-Juergen Schulten,Adeel G. Chaudhary,Adel M. Abuzenadah,Deema Hussein +12 more
TL;DR: Results strongly support the notion of heterogeneous populations of CSCs, even in grade I meningiomas, and call for the use of multiple markers for the accurate identification of individual CSC subgroups.
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Journal ArticleDOI
Sox10: a pan-schwannian and melanocytic marker.
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Journal ArticleDOI
Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein
Leonille Schweizer,Leonille Schweizer,Christian Koelsche,Christian Koelsche,Felix Sahm,Felix Sahm,Rosario M. Piro,David Capper,David Capper,David E. Reuss,David E. Reuss,Stefan Pusch,Antje Habel,Jochen Meyer,Tanja Göck,David T.W. Jones,Christian Mawrin,Jens Schittenhelm,Albert J. Becker,Stephanie Heim,Matthias Simon,Christel Herold-Mende,Gunhild Mechtersheimer,Werner Paulus,Rainer König,Rainer König,Otmar D. Wiestler,Stefan M. Pfister,Stefan M. Pfister,Andreas von Deimling,Andreas von Deimling +30 more
TL;DR: Exome sequencing was performed and the NAB2-STAT6 fusion protein was detected in DNA of 8/10 meningeal HPC thereby providing evidence of close relationship of these tumors with peripheral SFT and it is demonstrated that this fusion can be rapidly detected by STAT6 immunohistochemistry which shows a consistent nuclear reallocation.
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