Implications and Management of Cirrhosis-Associated Immune Dysfunction Before and After Liver Transplantation.
Thomas H. Tranah,Thomas H. Tranah,Victoria T. Kronsten,Victoria T. Kronsten,Debbie L. Shawcross,Debbie L. Shawcross +5 more
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TLDR
In this article, the authors summarize the detailed dynamic immunological perturbations associated with advanced chronic liver disease and highlight the importance of recognizing immune dysregulation as a sequela of cirrhosis.About:
This article is published in Liver Transplantation.The article was published on 2021-11-05 and is currently open access. It has received 3 citations till now. The article focuses on the topics: Chronic liver disease & Liver transplantation.read more
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Assessment of neutrophil subsets and immune checkpoint inhibitor expressions on T lymphocytes in liver transplantation: A preliminary study beyond the neutrophil-lymphocyte ratio
M. Haem Rahimi,M.C. Delignette,Morgane Gossez,Rémy Coudereau,Solene Pantel,Teresa Antonini,Francois Villeret,Fabien Zoulim,Jean-Yves Mabrut,Jérôme Dumortier,Fabienne Venet,Fanny Lebossé,Guillaume Monneret +12 more
TL;DR: In this article , the absolute count of immature neutrophils and LOX-1+ MDSC along with T lymphocyte count and checkpoint inhibitor expression were altered in cirrhotic patients before and after liver transplant.
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Characteristics of infections and their risk factors in children with biliary atresia.
Henry Shiau,Jeremy M. Schraw,Krupa R. Mysore,Laurel Cavallo,Sanjiv Harpavat,Philip J. Lupo,Flor M. Munoz,Benjamin L. Shneider +7 more
TL;DR: In this article , a retrospective observational study identified infections in children with biliary atresia (BA) using predefined criteria, including VRI, bacteremia with and without central line (CL), bacterial peritonitis, positive stool pathogens, urinary tract infections, and cholangitis.
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Beyond Varices: Complications of Cirrhotic Portal Hypertension in Pediatrics
TL;DR: In this paper , the authors summarize the current literature in adults who experience these complications of cirrhotic portal hypertension beyond variceal hemorrhage and present the available literature in children, with a focus on diagnosis, management, and liver transplant decision making in children with cirrhosis who develop ascites, SBP, HRS, HE, and cardiopulmonary complications.
References
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Intestinal Immune Dysregulation Driven by Dysbiosis Promotes Barrier Disruption and Bacterial Translocation in Rats With Cirrhosis.
Leticia Muñoz,Leticia Muñoz,M.J. Borrero,M.J. Borrero,M. Ubeda,M. Ubeda,Elisa Conde,Rosa del Campo,Macarena Rodríguez-Serrano,M. Lario,M. Lario,A.M. Sánchez-Díaz,Óscar Pastor,David Díaz,David Díaz,Laura García-Bermejo,Jorge Monserrat,Jorge Monserrat,Melchor Álvarez-Mon,Melchor Álvarez-Mon,Agustín Albillos,Agustín Albillos +21 more
TL;DR: The intestinal mucosa of rats with Cirrhosis acquires a proinflammatory profile of immune dysregulation that parallels the severity of cirrhosis; this impaired intestinal immune response is driven by gut dysbiosis and leads to disrupted barrier function, promoting GBT.
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Group 2 Innate Lymphoid Cells (ILC2): Type 2 Immunity and Helminth Immunity
TL;DR: This review covers the initial recognition of ILC2 as a distinct cell lineage, the key studies that established their biological importance, particularly in helminth infection, and the new directions that are likely to be the focus of emerging work that further explores this unique cell population in the context of health and disease.
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A randomized trial to assess whether portal pressure guided therapy to prevent variceal rebleeding improves survival in cirrhosis
Càndid Villanueva,Isabel Graupera,Carles Aracil,Edilmar Alvarado,Josep Miñana,Ángela Puente,Virginia Hernandez-Gea,Alba Ardevol,Oana Pavel,Alan Colomo,M Concepción,María Poca,Xavier Torras,Josep M a Reñe,Carlos Guarner +14 more
TL;DR: HVPG monitoring, by stratifying risk and targeting therapy, improves the survival achieved with currently recommended treatment to prevent VRB using β‐blockers and ligation.
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Neutrophils in liver diseases: pathogenesis and therapeutic targets.
TL;DR: The role of neutrophils in liver diseases is summarized with respect to viral hepatitis, nonalcoholic steatohepatitis, alcoholic liver disease, liver fibrosis, cirrhosis, liver failure, and liver cancer.
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Neutrophils: Many Ways to Die.
TL;DR: In this paper, a synthesis of the conditions and molecules implicated in the regulation and activation of the processes of neutrophil death: apoptosis, autophagy, pyroptosis, necroptosis and necrosis.